ETS2 Peptide (AAP31071)

Data Sheet
Sku AAP31071
Old sku AAPP01809
Price $99.00
Name ETS2 Peptide (AAP31071)
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Size 100 ug
Gene symbol ETS2
Alias symbols ETS2IT1
Gene id 2114
Description of target ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id P15036
Protein accession num NP_001120734
Nucleotide accession num NM_001127262
Protein size 469 amino acids
Molecular weight 53kDa
Application WB
Quality control The peptide is characterized by mass spectroscopy
Key reference Geng,C.D. (2005) J. Biol. Chem. 280 (52), 43264-43271
Description This is a synthetic peptide designed for use in combination with anti-ETS2 antibody (Catalog #: P100751_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days

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