Sku |
AAP31071 |
Old sku |
AAPP01809 |
Price |
$99.00 |
Name |
ETS2 Peptide (AAP31071) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
ETS2 |
Alias symbols |
ETS2IT1 |
Gene id |
2114 |
Description of target |
ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Swissprot id |
P15036 |
Protein accession num |
NP_001120734 |
Nucleotide accession num |
NM_001127262 |
Protein size |
469 amino acids |
Molecular weight |
53kDa |
Application |
WB |
Partner proteins |
BRCA1,NCOA3,NCOR1,SMARCA4,SRC,TDP2,CDK10,CREBBP,EP300,ERG,ETS1,ETS2,GATA3,JUN,NCOR1,NR3C1,POU5F1,SMARCA4,SRC,STAT5B,TDP2,ZFYVE9,ZMYND11,CDK10,EP300,ERG,ETS1,FOS,JUN,NR3C1,SPI1,ZMYND11 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Geng,C.D. (2005) J. Biol. Chem. 280 (52), 43264-43271 |
Description |
This is a synthetic peptide designed for use in combination with anti-ETS2 antibody (Catalog #: P100751_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
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Tips |
See our General FAQ page. |
Availability |
In Stock |