| Sku |
AAP31053 |
| Old sku |
AAPP01787 |
| Price |
$99.00 |
| Name |
ERCC2 Peptide - N-terminal region (AAP31053) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
ERCC2 |
| Alias symbols |
COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD |
| Gene id |
2068 |
| Description of target |
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. ERCC2 is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. This protein has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P18074 |
| Protein accession num |
NP_000391 |
| Nucleotide accession num |
NM_000400 |
| Protein size |
760 amino acids |
| Molecular weight |
87kDa |
| Application |
WB |
| Partner proteins |
CDK1,CDK7,ERCC2,ERCC3,ERCC5,GTF2H1,GTF2H2,RAD51,RAD52,ERCC3,ERCC5,GTF2H1,GTF2H2,HERC5,ISG15,TP53,TRIM25 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Braun,M.S., (2008) J. Clin. Oncol. 26 (16), 2690-2698 |
| Description |
This is a synthetic peptide designed for use in combination with anti-ERCC2 antibody (Catalog #: P100701_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
