CCR5 Peptide - middle region (AAP30788)

Data Sheet
 
Sku AAP30788
Old sku AAPP01451
Price $99.00
Name CCR5 Peptide - middle region (AAP30788)
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Size 100 ug
Gene CCR5
Alias symbols CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Gene id 1234
Description of target CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
Swissprot id P51681
Protein accession num NP_000570
Nucleotide accession num NM_000579
Protein size 352 amino acids
Molecular weight 41kDa
Application WB
Partner proteins ADRBK1,ADRBK2,AFP,ARL6IP5,ARRB1,CCL11,CCL13,CCL14,CCL16,CCL2,CCL3,CCL3L1,CCL3L3,CCL4,CCL5,CCL7,CCL8,CCR2,CCR5,CD4,CXCR4,DNM2,GNAI1,GNAI2,GNAI3,GNAO1,GNAQ,JAK1,JAK2,LCK,ORM1,PRAF2,PSMA5,PTK2,PTK2B,STAT1,STAT3,STAT5A,TXK,AFP,ARRB1,CCL3,CCL3L1,CCL5,CD4,CXCR4,JAK2,PIK3R2,PTK2,STAT3,STAT5B
Quality control The peptide is characterized by mass spectroscopy
Key reference Catano,G., (2008) J. Infect. Dis. 198 (1), 72-80
Description This is a synthetic peptide designed for use in combination with anti-CCR5 antibody (Catalog #: ARP30788_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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