| Sku |
AAP30723 |
| Old sku |
AAPP01380 |
| Price |
$99.00 |
| Name |
RAB8A Peptide - middle region (AAP30723) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
RAB8A |
| Alias symbols |
MEL, RAB8 |
| Gene id |
4218 |
| Description of target |
RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable.The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P61006 |
| Protein accession num |
NP_005361 |
| Nucleotide accession num |
NM_005370 |
| Protein size |
207 amino acids |
| Molecular weight |
24kDa |
| Application |
WB |
| Partner proteins |
OPTN,RAB3IP,BAT3,GDI2,MAP4K2,OCRL,OPTN,PDE6D,PQBP1,RAB3IP,RABIF,RIMS2,RPH3A,RPH3AL,SYTL4,BAT3,GDI2,MAP4K2,OPTN,RAB10,RIMS2,RPH3A,RPH3AL,SYTL4 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Roland,J.T., (2007) Mol. Biol. Cell 18 (8), 2828-2837 |
| Description |
This is a synthetic peptide designed for use in combination with anti-RAB8A antibody (Catalog #: AVARP13076_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
