CHRNB3 Peptide (AAP30678)

Data Sheet
 
Sku AAP30678
Old sku AAPP01335
Price $99.00
Name CHRNB3 Peptide (AAP30678)
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Size 100 ug
Gene CHRNB3
Gene id 1142
Description of target Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.
Swissprot id Q05901
Protein accession num NP_000740
Nucleotide accession num NM_000749
Protein size 458 amino acids
Molecular weight 53kDa
Application WB
Subunit beta-3
Quality control The peptide is characterized by mass spectroscopy
Key reference Boorman,J.P., et al., (2003) J. Biol. Chem. 278 (45), 44033-44040
Description This is a synthetic peptide designed for use in combination with anti-CHRNB3 antibody (Catalog #: AVARP13021_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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