| Sku |
AAP30674 |
| Old sku |
AAPP01331 |
| Price |
$99.00 |
| Name |
CHRNA7 Peptide (AAP30674) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
CHRNA7 |
| Alias symbols |
NACHRA7, CHRNA7-2 |
| Gene id |
1139 |
| Description of target |
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene. |
| Swissprot id |
P36544 |
| Protein accession num |
NP_000737 |
| Nucleotide accession num |
NM_000746 |
| Protein size |
502 amino acids |
| Molecular weight |
56kDa |
| Application |
WB |
| Partner proteins |
ADCY6,APP,PIK3R1,ADCY6,FYN |
| Subunit |
alpha-7 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Avramopoulou,V., et al., (2004) J. Biol. Chem. 279 (37), 38287-38293 |
| Description |
This is a synthetic peptide designed for use in combination with anti-CHRNA7 antibody (Catalog #: AVARP13018_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
