| Sku |
AAP30671 |
| Old sku |
AAPP01328 |
| Price |
$99.00 |
| Name |
CHRNA4 Peptide - N-terminal region (AAP30671) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
CHRNA4 |
| Alias symbols |
BFNC, EBN, EBN1, NACRA4, NACHR, NACHRA4 |
| Gene id |
1137 |
| Description of target |
CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P43681 |
| Protein accession num |
NP_000735 |
| Nucleotide accession num |
NM_000744 |
| Protein size |
627 amino acids |
| Molecular weight |
70kDa |
| Application |
WB |
| Partner proteins |
CHRNB2,CHRNB2,CHRNB4,CRELD2,UBQLN1,VSNL1,YWHAH,YWHAH |
| Subunit |
alpha-4 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Fedi,M., (2008) J. Clin. Endocrinol. Metab. 93 (2), 634-637 |
| Description |
This is a synthetic peptide designed for use in combination with anti-CHRNA4 antibody (Catalog #: AVARP13015_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
