CHRNG Peptide - N-terminal region (AAP30670)

Data Sheet
Sku AAP30670
Old sku AAPP01327
Price $99.00
Name CHRNG Peptide - N-terminal region (AAP30670)
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Size 100 ug
Alias symbols ACHRG
Gene id 1146
Description of target The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[
Swissprot id Q86U77
Protein accession num NP_000734
Nucleotide accession num NM_000743
Protein size 505 amino acids
Molecular weight 57kDa
Application WB
Partner proteins Ubqln1; CHRNB4;
Subunit alpha-3
Quality control The peptide is characterized by mass spectroscopy
Key reference Boorman,J.P., et al., (2003) J. Biol. Chem. 278 (45), 44033-44040
Description This is a synthetic peptide designed for use in combination with anti-CHRNA3 antibody (Catalog #: AVARP13014_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days

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