| Sku |
AAP30613 |
| Old sku |
AAPP01266 |
| Price |
$99.00 |
| Name |
SREBF1 Peptide (AAP30613) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
SREBF1 |
| Alias symbols |
SREBP1, bHLHd1, SREBP-1c |
| Gene id |
6720 |
| Description of target |
SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. |
| Swissprot id |
P36956 |
| Protein accession num |
NP_001005291 |
| Nucleotide accession num |
NM_001005291 |
| Protein size |
1177 amino acids |
| Molecular weight |
125kDa |
| Application |
IHC, WB |
| Partner proteins |
ATXN1,CREBBP,ESR1,ESR2,ID3,LMNA,MAPK1,MAPK3,NR0B1,SMARCD3,SP1,SREBF1,SUMO1,TWIST2,UBE2I,YY1,CREBBP,GAL11,LMNA,MAPK1,MAPK3,NR0B1,SP1,TWIST2,UBE2I,YY1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Motoyama,K., (2006) Biochem. Biophys. Res. Commun. 342 (1), 354-360 |
| Description |
This is a synthetic peptide designed for use in combination with anti-SREBF1 antibody (Catalog #: AVARP09051_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
