NFKB1 Peptide - middle region (AAP30581)

Data Sheet
 
Sku AAP30581
Old sku AAPP01233
Price $99.00
Name NFKB1 Peptide - middle region (AAP30581)
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Size 100 ug
Gene NFKB1
Alias symbols DKFZp686C01211, EBP-1, KBF1, MGC54151, NF-kappa-B, NFKB-p105, NFKB-p50, p50, p105, NFkappaB, NF-kappaB
Gene id 4790
Description of target NFKB1 is a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id P19838-2
Protein accession num NP_003989
Nucleotide accession num NM_003998
Protein size 969 amino acids
Molecular weight 105kDa
Application WB
Partner proteins BCL3,BCL3,BIRC3,CD82,CTNNB1,IL8,KAT5,NCOA1,NFKB1,NFKB1,NFKBIA,RELA,RELA,RUVBL2,SPAG9,AR,ATF3,BCL3,BRCA1,BTRC,CDK9,CEBPB,CFLAR,CHUK,CTNNB1,E2F1,ELF1,ELF3,ESR1,ETS1,FBXW11,FOS,G3BP2,GSK3B,HDAC1,HMGA2,HMGB1,IKBKB,IKBKG,IL2RA,IRF1,IRF2,ITGB3BP,KAT5,KLF5,KPNA3,LYL1,MAP3K8,MEN1,MTPN,NCF1,NCOA1,NCOR2,NFKB1,NFKB2,NFKBIA,NFKBIB,NFKBIE,NFKBIZ,NFRKB,NKRF,NOTCH1,NR3C1,PARP1,PDCD11,PPP4C,PRKACA,REL,RELA,RELB,RIPK1,RSF1,RXRA,SPAG9,SPI1,STAT3,STAT6,TNFSF11,TNIP2,TP53BP1,TRIP4,TSC22D3,TXN,UBE2D3,UBE2K,UNC5CL,BCL3,BTRC,CEBPB,CHUK,COPB2,E2F1,ELF1,ELF3,GSK3B,HDAC1,HMGA2,HMGB1,IKBKB,IKBKG,IRF2,IRF8,IRF9,ITGB3BP,KLF5,KPNA3,LYL1,MAP3K8,MEN1,MTPN,NCOA1,NCOA6,NCOR1,NFKB1,NFKB2,NFKBIA,NFKBIE,NFKBIZ,NKRF,NOTCH1,NR3C1,PPP4C,REL,RELA,RELB,RSF1,RXRA,SP1,SPAG9,STAT3,STAT6,TAB2,TBK1,TNIP2,TNIP3,TP53BP1,TSC22D3,TXN,UNC5CL
Quality control The peptide is characterized by mass spectroscopy
Key reference Droll,L., (2008) Biochem. Biophys. Res. Commun. 371 (4), 626-629
Description This is a synthetic peptide designed for use in combination with anti-NFKB1 antibody (Catalog #: AVARP09048_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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Optimal conditions of its use should be determined by end users.

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