BIRC7 Peptide - middle region (AAP30562)

Data Sheet
 
Sku AAP30562
Old sku AAPP01214
Price $99.00
Name BIRC7 Peptide - middle region (AAP30562)
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Size 100 ug
Gene BIRC7
Alias symbols KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Gene id 79444
Description of target BIRC7 protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
Swissprot id Q96CA5
Protein accession num NP_647478
Nucleotide accession num NM_139317
Protein size 298 amino acids
Molecular weight 33kDa
Application WB
Partner proteins CASP3,CASP7,CASP9,DIABLO,HTRA2,CASP3,CASP7,CASP9,XAF1
Quality control The peptide is characterized by mass spectroscopy
Key reference Dynek,J.N., (2008) Cancer Res. 68 (9), 3124-3132
Description This is a synthetic peptide designed for use in combination with anti-BIRC7 antibody (Catalog #: AVARP02033_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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