| Sku |
AAP30521 |
| Old sku |
AAPP01157 |
| Price |
$99.00 |
| Name |
TNFRSF1A Peptide - N-terminal region (AAP30521) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
TNFRSF1A |
| Alias symbols |
CD120a, FPF, MGC19588, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60 |
| Gene id |
7132 |
| Description of target |
TNFRSF1A is the receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNFRSF1A contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P19438 |
| Protein accession num |
NP_001056 |
| Nucleotide accession num |
NM_001065 |
| Protein size |
455 amino acids |
| Molecular weight |
48kDa |
| Application |
IHC, WB |
| Partner proteins |
ERAP1,GNB2L1,MOAP1,NSMAF,RALBP1,RASSF1,TNF,TNFRSF1A,TRADD,TRADD,TRADD,BAG4,CASP10,CASP7,CHUK,DAPK1,ERAP1,ERN1,FANCD2,GNB2L1,GRB2,HSP90AA1,IKBKB,IKBKG,JAK1,JAK2,LTA,LTB,MADD,MAPK1,MOAP1,MYOC,NSMAF,PIP4K2B,PSMD2,PTK2,PTPN11,PTPN6,RASSF1,RIPK1,RIPK2,RIPK3,STAT1,SUMO1,SYK,TNF,TNFRSF1A,TNFRSF25,TNFSF13,TRADD,TRAF1,TRAF2,TRAP1,TRPC4AP,UBE2I,ARHGDIA,BAG4,BCL10,BID,BIRC2,BIRC3,CASP10,CASP2,CASP7,CASP8,CEP110,CRADD,DAPK1,EZR,FADD,FANCD2,FAS,FASLG,GRB2,HSPA8,IKBKB,IKBKG,JAK1,JAK2,LTA,LTB,MADD,MAPK8,MSN,NOL3,NSMAF,PIP4K2B,PSMD2,RHOA,RIPK1,RIPK2,RIPK3,STAT1,SUMO1,TNF,TNFRSF10B,TNFRSF1A,TNFSF13,TRADD,TRAF1,TRAF2,TRAP1,TRPC4AP,UBE2I |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Gattorno,M., (2008) Arthritis Rheum. 58 (6), 1823-1832 |
| Description |
This is a synthetic peptide designed for use in combination with anti-TNFRSF1A antibody (Catalog #: AVARP00034_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
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