TOP2A Peptide (AAP30464)

Data Sheet
Sku AAP30464
Old sku AAPP01048
Price $99.00
Name TOP2A Peptide (AAP30464)
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Size 100 ug
Gene TOP2A
Alias symbols TOP2, TP2A
Gene id 7153
Description of target TOP2A is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Swissprot id P11388
Protein accession num NP_001058
Nucleotide accession num NM_001067
Protein size 1531 amino acids
Molecular weight 174kDa
Application WB
Quality control The peptide is characterized by mass spectroscopy
Key reference Yoshida,K., et al., (2006) Mol. Cell. Biol. 26 (9), 3414-3431
Description This is a synthetic peptide designed for use in combination with anti-TOP2A antibody (Catalog #: AVARP04007_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days

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