| Sku |
AAP30464 |
| Old sku |
AAPP01048 |
| Price |
$99.00 |
| Name |
TOP2A Peptide (AAP30464) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
TOP2A |
| Alias symbols |
TOP2, TP2A |
| Gene id |
7153 |
| Description of target |
TOP2A is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
| Swissprot id |
P11388 |
| Protein accession num |
NP_001058 |
| Nucleotide accession num |
NM_001067 |
| Protein size |
1531 amino acids |
| Molecular weight |
174kDa |
| Application |
WB |
| Partner proteins |
E2F4,BRCA1,BRCA1,CDK1,CSNK2A1,DFFB,DHX9,HDAC1,HDAC2,JUN,PIN1,PRKCA,PRKCB,PRKCG,RB1,SRPK1,SUMO1,SUMO4,TOP2B,TP53,XPO1,YWHAE,AIRE,CDC5L,CDT1,DFFB,DHX9,HDAC1,HDAC2,JUN,PIN1,SUMO1,TOP2B,TP53,XRCC5,YWHAE |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Yoshida,K., et al., (2006) Mol. Cell. Biol. 26 (9), 3414-3431 |
| Description |
This is a synthetic peptide designed for use in combination with anti-TOP2A antibody (Catalog #: AVARP04007_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
