| Sku |
AAP30439 |
| Old sku |
AAPP01023 |
| Price |
$99.00 |
| Name |
CCND1 Peptide - middle region (AAP30439) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
CCND1 |
| Alias symbols |
BCL1, D11S287E, PRAD1, U21B31 |
| Gene id |
595 |
| Description of target |
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P24385 |
| Protein accession num |
NP_444284 |
| Nucleotide accession num |
NM_053056 |
| Protein size |
295 amino acids |
| Molecular weight |
34kDa |
| Application |
WB |
| Partner proteins |
CHUK,CREBBP,CTNNB1,ERCC3,ESR1,NCOA3,POLR2A,RELA,BRCA1,CDK4,CDK4,CDK6,CDKN1A,CDKN1A,CDKN1A,CDKN1B,KLF6,PIN1,RB1,TAF1,FOXO4,AKAP8,AR,BRCA1,CALM1,CCNDBP1,CDK4,CDK6,CDKN1A,CDKN1B,CTNNB1,CUL3,DMTF1,EP300,ESR1,GSK3B,HDAC3,HERC5,IFI27,INSM1,KAT2B,MCM10,MYBL2,NCOA1,NCOA3,NPDC1,ORC4L,PCNA,PRKACA,RB1,RBL1,RBL2,RBX1,RFC1,RUNX1,SP1,STAT3,TAF1,THRA,THRB,TSC2,CREB1,EGFR,STAT3,AKAP8,AR,BRCA1,CCNDBP1,CDK4,CDK6,CDKN1A,CDKN1B,CDKN1C,CDKN2A,EP300,ESR1,HDAC3,HERC5,KAT2B,Mybl2,NCOA1,NCOA3,NEUROD1,NPDC1,PCNA,RB1,RBX1,RFC1,STAT3,TAF1,THRA,THRB,TSC2,XPO1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Kibel,A.S., (2008) Prostate 68 (11), 1179-1186 |
| Description |
This is a synthetic peptide designed for use in combination with anti-CCND1 antibody (Catalog #: AVARP03037_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
|
