BRCA1 Peptide (AAP30434)

Data Sheet
 
Sku AAP30434
Old sku AAPP01017
Price $99.00
Name BRCA1 Peptide (AAP30434)
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Size 100 ug
Gene BRCA1
Alias symbols IRIS, PSCP, BRCAI, BRCC1, PNCA4, RNF53, BROVCA1, PPP1R53
Gene id 672
Description of target BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression.
Swissprot id P38398
Protein accession num NP_009229
Nucleotide accession num NM_007298
Protein size 680 amino acids
Molecular weight 76kDa
Application IHC, WB
Partner proteins ETS2,CREBBP,EP300,MAP3K3,MED1,BRCA1,SMAD2,SMAD3,SMAD4,UBB,ACACA,ATR,BRCA2,CCNA1,CCNB1,CCND1,CDK2,CDK4,CSNK2B,E2F1,E2F4,FANCA,HDAC1,HDAC2,JUN,JUNB,JUND,LMO4,MSH2,MSH6,MYC,NFYA,NMI,NUFIP1,POU2F1,RAD51,RAD51,RB1,RBBP4,RBBP7,RBBP8,SP1,TP53,TP53,ABL1,ACACA,AKT1,AR,ATF1,ATR,AURKA,BAP1,BARD1,BRAP,BRCA1,BRCA2,BRCC3,BRIP1,CASP3,CCNA1,CCNA2,CCNB1,CCND1,CDK1,CDK2,CDK4,CDK7,CHEK2,CLSPN,COBRA1,CREBBP,CSNK2A1,CSNK2B,CSTF1,CTBP1,DCLRE1C,DHX9,E2F1,E2F4,ELK1,EP300,ESR1,FAM175A,FANCA,FANCD2,FHL2,GFI1B,H2AFX,HDAC1,HDAC2,IFI16,JAK1,JAK2,JUN,JUNB,JUND,KPNA2,KPNA6,LMO4,MAP3K3,MDC1,MED1,MED21,MLH1,MNAT1,MYC,NBN,NFKB1,NFYA,NMI,NUFIP1,POLR2A,POLR2K,POU2F1,PPP1CA,PSAP,RAD51,RB1,RBBP4,RBBP7,RBBP8,RELA,RFC1,SMAD2,SMAD3,SMAD4,SMARCA2,SMARCA4,SMC1A,SP1,STAT1,STAT3,STAT5A,TOP2A,TP53,TP53BP1,TRRAP,TUBA4A,TUBB,TUBG1,UBB,UBE2D3,UBE2L3,USF2,VCP,XRCC1,YY1,ZNF350,ABL1,ACACA,AKT1,APLP2,AR,ASM4,ATF1,ATM,ATR,AURKA,BACH1,BARD1,BLM,BRAP,BRCA1,BRCA2,BRCC3,BRD7,BRE,BRIP1,CCNA1,CCNA2,CCNB1,CCND1,CCNE1,CCR4,CDK1,CDK16,CDK2,CDK4,CDK5,CDK8,CDS1,CHEK2,CLSPN,COBRA1,CREB1,CREBBP,CSNK2A1,CSNK2B,CSTF1,CSTF2,CTBP1,CTCFL,DEF1,DHH1,DHX9,DNAJA3,E2F4,ELK4,EP300,ESR1,ETS1,FANCA,FANCD2,FHL2,FLI1,GTF2E1,GTF2F1,GTF2H4,H2AFX,H2AFY,HDAC1,HDAC2,HIST2H2AC,HIST2H3C,HSPA8,Ifi204,JAK1,JAK2,JUN,JUNB,JUND,KIF1B,KPNA2,LMO4,MAP3K3,MAP4K4,MDC1,MED1,MED13,MED17,MED21,MED23,MED24,MLH1,MLP2,MRE11A,MRPL39,MSH2,MSH3,MSH6,MYC,NBN,NCOA2,NCOA3,NFYA,NMI,NPM1,NUFIP1,NUP120,NUP133,NUP153,NUP170,NUP188,NUP2,ORC2L,ORC3L,PEG3,POLR2A,POM34,POU2F1,PPP1CA,PPP1CB,PPP1R3A,PRKDC,RAD50,RAD51,RB1,RBBP4,RBBP7,RBBP8,RBL1,RBL2,RELA,RFC1,RPL31,SMARCA2,SMARCA4,SMARCB1,SMARCC1,SMARCC2,SMARCD2,SP1,SPT4,SPT5,STAT1,STAT5A,SUB1,TOP2A,TP53,TP53BP1,TUBG1,UBA1,UBC,UBE2D1,UBE2L3,UBE3A,UIMC1,USF2,VCP,WDR48,WNT2B,XIST,ZCCHC8,ZNF350
Quality control The peptide is characterized by mass spectroscopy
Key reference Mark,W.Y., et al., (2005) J. Mol. Biol. 345 (2), 275-287
Description This is a synthetic peptide designed for use in combination with anti-BRCA1 antibody (Catalog #: AVARP02017_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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