AIFM1 Peptide - middle region (AAP30425)

Data Sheet
 
Sku AAP30425
Old sku AAPP01008
Price $99.00
Name AIFM1 Peptide - middle region (AAP30425)
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Size 100 ug
Gene AIFM1
Alias symbols AIF, MGC111425, PDCD8, COXPD6
Gene id 9131
Description of target AIFM1 is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this protein induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene.This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.
Swissprot id O95831
Protein accession num NP_004199
Nucleotide accession num NM_004208
Protein size 613 amino acids
Molecular weight 67kDa
Application WB
Partner proteins C4orf14,CASP3,EIF3G,HSPA1A,HSPA1B,SETDB1,STC2,TSC22D4,WWC1,BRF2,C20orf24,HSPA1A,MLF2,MLH1,PELO,PMS2,PTP4A3,SETDB1,STC2,UBC,XIAP
Quality control The peptide is characterized by mass spectroscopy
Key reference Desmots,F., (2008) J. Biol. Chem. 283 (6), 3264-3271
Description This is a synthetic peptide designed for use in combination with anti-AIFM1 antibody (Catalog #: AVARP02013_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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