CDC42 Peptide (AAP30406)

Data Sheet
 
Sku AAP30406
Old sku AAPP00929
Price $99.00
Name CDC42 Peptide (AAP30406)
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Size 100 ug
Gene CDC42
Alias symbols CDC42Hs, G25K
Gene id 998
Description of target CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Swissprot id P60953
Protein accession num NP_001782
Nucleotide accession num NM_001791
Protein size 191 amino acids
Molecular weight 21kDa
Application WB
Partner proteins WAS,CDC42EP2,CDC42EP3,ITSN1,MCF2L,WAS,ACTR3,ANXA2,ARHGAP1,ARHGAP31,ARHGDIA,ARHGDIB,ARHGDIG,ARHGEF6,ARHGEF7,BAIAP2,BNIP2,C14orf1,C1orf103,CASP3,CASP7,CDC42BPG,CDC42EP1,CDC42EP2,CDC42EP3,CDC42EP5,CDC42SE1,CSPG4,DEF6,DOCK7,DOCK8,DOCK9,EEF1G,EIF2AK2,ERRFI1,FGD1,FLNA,FNBP1,GDI1,GEFT,IQGAP1,IQGAP2,ITSN1,KAT5,KTN1,LCK,MAP3K10,MAP3K11,MAP3K4,MARK4,MCF2L,METAP2,MYO9A,NCF2,OCRL,OPHN1,PAK1,PAK2,PAK4,PAK6,PAK7,PARD3,PARD6A,PARD6B,PARD6G,PDE6D,PGGT1B,PIK3R1,PLD1,PLEKHG2,PRKCA,PRKCG,PRKCI,PRKCZ,RAC2,RHOJ,RPS6KB1,SRGAP1,STAU1,TBC1D3F,TNK2,TP53,TRIP10,UBR1,UNC119,VAV1,WAS,WASF1,WASF2,ARHGAP1,ARHGAP1,ARHGAP10,ARHGAP17,ARHGAP26,ARHGAP27,ARHGAP29,ARHGAP32,ARHGAP8,ARHGDIA,ARHGDIG,ARHGEF6,ARHGEF7,BAIAP2,BCR,BNIP2,BNIP2,BNIP2,BNIP2,BNIPL,C14orf1,C1orf103,CDC42,CDC42BPG,CDC42EP1,CDC42EP2,CDC42EP3,CDC42EP5,CDC42SE1,CDC42SE2,CLIP1,CNTNAP1,CSPG4,DEF6,DEF6,DOCK8,DOCK9,Diap3,EEF1G,ERRFI1,FGD1,FNBP1L,GDI1,GEFT,GOPC,IQGAP1,IQGAP2,ITSN1,KAT5,Kin,MAP3K10,MAP3K11,MAP3K4,MCF2,MCF2L,NCF2,Net1,OPHN1,PAK1,PAK1,PAK1,PAK2,PAK4,PAK6,PAK7,PARD6A,PARD6B,PARD6G,PDE6D,PLD1,PLEKHG2,RAC1,RICH2,Rock1,TBC1D3F,TNK2,TP53,TRIP10,UBR1,UNC119,VAV1,WAS,WAS,WASL,tax
Quality control The peptide is characterized by mass spectroscopy
Key reference Black,S.A. (2008) J. Biol. Chem. 283 (16), 10835-10847
Description This is a synthetic peptide designed for use in combination with anti-CDC42 antibody (Catalog #: AVARP01017_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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