Sku |
AAP30292 |
Old sku |
AAPS08702 |
Price |
$99.00 |
Name |
MYC Peptide - N-terminal region (AAP30292) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
MYC |
Alias symbols |
c-Myc, MRTL, bHLHe39 |
Gene id |
4609 |
Description of target |
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Swissprot id |
P01106-2 |
Protein accession num |
NP_002458 |
Nucleotide accession num |
NM_002467 |
Protein size |
454 amino acids |
Molecular weight |
50kDa |
Application |
WB |
Partner proteins |
E2F1,E2F4,E2F5,CHUK,ESR1,FUBP1,NCOA3,ORC2L,POLR2A,XRCC5,BRCA1,CDK4,CDKN1A,CDKN1A,CDKN1A,CDKN2A,CSNK2A1,DDB2,DNMT3A,FBXW7,FBXW7,KAT2A,MAPK3,MAX,MIR17HG,MLH1,MYCBP2,NCL,NFYB,NFYC,NMI,NPM1,PARP10,PMAIP1,PML,RIBIN,RRM2B,SP1,SP1,TAF1A,TAF1B,TAF1C,TBP,TRRAP,ACTL6A,BCL2,BIN1,BRCA1,CCNT1,CDC6,CDK1,CDKN2A,CEBPA,CEBPB,CREBBP,CSNK2A1,CSNK2A2,DNMT3A,ELF3,EP300,FBXW7,GSK3B,GTF2F1,GTF2I,HSP90AA1,KAT2A,KAT5,MAP2K1,MAPK3,MAPK7,MAPK8,MAX,MINA,MLH1,MXD1,MXI1,MYCBP,MYCBP2,NFYB,NFYC,NMI,PARP10,PFDN5,PML,PRDX1,RAF1,RAGE,RB1,RBL1,RELA,SKP2,SMAD2,SMAD3,SMARCB1,SNIP1,SP1,SPAG9,SUPT3H,TAF1B,TBP,TFAP2B,TIAM1,TP73,TRRAP,TUBA1A,TUBA1B,TUBA3C,TUBA4A,TUBA8,UBB,YY1,ZBTB17,ACTB,ACTL6A,ARHGEF2,BCL2,BRCA1,BRD7,CCNT1,CD6,CDC6,CDK9,CEBPA,CEBPB,DDX24,DNMT3A,EFTUD2,EP400,EXOC4,Eif4e,FANCI,FBXW7,GCN1L1,GEMIN4,GTF2B,GTF2F1,GTF2I,GTF3C3,HEATR1,HNRNPC,HSP90AA1,KAT2A,KAT2B,KAT5,KIAA1967,MAPK1,MAPK3,MAPK8,MAX,MCM7,MED12,MED14,METTL13,MKLN1,MLH1,MSH2,MSH6,MYBBP1A,MYCBP,MYCBP2,MYO1B,NFYB,NFYC,NMI,NUP205,NUP93,PDS5A,PFDN5,PIAS2,POLE,POLR2A,PRPF8,RAF1,RB1,RBL1,RELA,RUVBL1,RUVBL2,SAP130,SMAD2,SMAD3,SMARCA4,SMARCB1,SNRNP200,SP1,SUPT3H,TADA2A,TADA3,TAF10,TAF12,TAF5,TAF5L,TAF6L,TAF9,TBP,TFAP2A,TIAM1,TP73,TRRAP,UBB,YY1,ZBTB17 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Zhu,J., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (18), 6584-6589 |
Description |
This is a synthetic peptide designed for use in combination with anti-MYC antibody (Catalog #: ARP30292_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
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Tips |
See our General FAQ page. |
Availability |
In Stock |
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