| Sku |
AAP30258 |
| Old sku |
AAPP00428 |
| Price |
$99.00 |
| Name |
BCL2L1 Peptide - N-terminal region (AAP30258) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
BCL2L1 |
| Alias symbols |
BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS, BCLXL, BCLXS, PPP1R52 |
| Gene id |
598 |
| Description of target |
BCL2L1 encodes a protein which belongs to the BCL-2 protein family. The proteins encoded by BCL2L1 are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. |
| Swissprot id |
Q07817 |
| Protein accession num |
NP_612815 |
| Nucleotide accession num |
NM_138578 |
| Protein size |
233 amino acids |
| Molecular weight |
26kDa |
| Application |
WB |
| Partner proteins |
CRYAA,CRYAB,BAD,BAD,BAD,BAX,BAX,BAX,BBC3,BBC3,BBC3,BCL2L11,BCL2L11,BID,BID,BID,BID,BID,BIK,BIK,BMF,BMF,HRK,HRK,HRK,MOAP1,RTN1,RTN4,TP53,TPT1,ANTXR1,APAF1,AVEN,BAD,BAG1,BAK1,BAX,BBC3,BCAP31,BCL2,BCL2L1,BCL2L10,BCL2L11,BCL2L12,BCL2L14,BCLAF1,BECN1,BID,BIK,BMF,BNIP1,BNIP3,BNIP3L,CAPN1,CASP1,CASP8,CASP9,CFLAR,CRYAA,CRYAB,CYCS,FKBP8,HRK,IKZF3,IRS1,IRS2,MAPK8,MCL1,MOAP1,NLRP1,PMAIP1,PPP1CA,PSEN1,PSEN2,RAD9A,RTN1,RTN4,SIVA1,SNCA,SPNS1,TMBIM6,TP53,VDAC1,APAF1,AVEN,BAD,BAK1,BAX,BBC3,BCAP31,BCL2,BCL2L11,BCL2L14,BECN1,BID,BIK,BLK,BNIP1,BNIP3,BNIPL,Bcl2l11,CASP2,CASP8,CASP9,CFLAR,CFLAR,CYCS,DYNLL1,FKBP8,HRK,IKZF3,IRS1,MCL1,MOAP1,PGAM5,PMAIP1,PPP1CA,PSEN1,PSEN2,RAD9A,RAF1,RTN1,RTN4,SPNS1,VDAC1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Xu,C., (2008) J. Biol. Chem. 283 (17), 11477-11484 |
| Description |
This is a synthetic peptide designed for use in combination with anti-BCL2L1 antibody (Catalog #: AVARP02002_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
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