| Sku |
AAP30256 |
| Old sku |
AAPP00426 |
| Price |
$99.00 |
| Name |
TRADD Peptide - middle region (AAP30256) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
TRADD |
| Alias symbols |
Hs.89862, MGC11078 |
| Gene id |
8717 |
| Description of target |
TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
Q15628 |
| Protein accession num |
NP_003780 |
| Nucleotide accession num |
NM_003789 |
| Protein size |
312 amino acids |
| Molecular weight |
34kDa |
| Application |
WB |
| Partner proteins |
FADD,FADD,KRT14,KRT18,NGFR,TNFRSF1A,TNFRSF1A,TRAF2,BCL10,BIRC3,CEP110,DAPK1,FADD,FAS,HIPK2,KRT14,KRT18,NGFR,PPP2R1A,RIPK1,STAT1,TNFRSF10A,TNFRSF10B,TNFRSF1A,TNFRSF21,TNFRSF25,TRADD,TRAF1,TRAF2,TRAF3,TRPC4AP,BCL10,CASP8,CAV1,FADD,FADD,HIPK2,KRT18,NGFR,NOL3,RIPK1,STAT1,TNF,TNFRSF10A,TNFRSF10B,TNFRSF1A,TNFRSF1A,TNFRSF21,TNFRSF25,TRADD,TRAF1,TRAF2,TRAF2,TRPC4AP |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Miyagawa,H., (2008) Rheumatology (Oxford) 47 (2), 158-164 |
| Description |
This is a synthetic peptide designed for use in combination with anti-TRADD antibody (Catalog #: AVARP02012_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
