RAD17 Peptide (AAP30206)

Data Sheet
 
Sku AAP30206
Old sku AAPS09009
Price $99.00
Name RAD17 Peptide (AAP30206)
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Size 100 ug
Gene RAD17
Alias symbols CCYC, HRAD17, R24L, RAD17Sp, Rad24, RAD24, RAD17SP
Gene id 5884
Description of target RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.
Swissprot id O75943-4
Protein accession num NP_579919
Nucleotide accession num NM_133341
Protein size 584 amino acids
Molecular weight 66kDa
Application WB
Partner proteins ATM,ATR,HUS1,MCM7,NHP2L1,POLE,RAD1,RAD9A,RAD9B,RFC4,ALK,ATM,ATR,HUS1,NHP2L1,POLE,POLE2,POLE3,POLE4,PRKDC,RAD1,RAD9A,RAD9B,RFC1,RFC2,RFC3,RFC4,RFC5,USP20
Quality control The peptide is characterized by mass spectroscopy
Key reference Tsao,C.C., (2004) EMBO J. 23 (23), 4660-4669
Description This is a synthetic peptide designed for use in combination with anti-RAD17 antibody (Catalog #: ARP30206_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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