| Sku |
AAP30180 |
| Old sku |
AAPS08908 |
| Price |
$99.00 |
| Name |
FKBP4 Peptide (AAP30180) |
| Purchase info |
To purchase this peptide:
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
FKBP4 |
| Alias symbols |
FKBP52, FKBP59, HBI, Hsp56, PPIase, p52, FKBP51 |
| Gene id |
2288 |
| Description of target |
FKBP4 is a component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. It may have a rotamase activity. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P30416 |
| Protein accession num |
NP_002005 |
| Nucleotide accession num |
NM_002014 |
| Protein size |
459 amino acids |
| Molecular weight |
52kDa |
| Application |
IHC, WB |
| Partner proteins |
ACVR1,ATOX1,CSNK2A1,FKBP1A,GLMN,IRF4,NR3C1,NR3C2,PHYH,PTPN2,SMURF2,ESR1,FES,GLMN,HSF1,IRF4,LOXHD1,NR3C1,PHYH,SAE1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Ruan,B., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (1), 33-38 |
| Description |
This is a synthetic peptide designed for use in combination with anti-FKBP4 antibody (Catalog #: ARP30180_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
