Sku |
AAP30172 |
Old sku |
AAPS08904 |
Price |
$99.00 |
Name |
CCNT1 Peptide - N-terminal region (AAP30172) |
Purchase info |
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|
Size |
100 ug |
Gene |
CCNT1 |
Alias symbols |
CCNT, CYCT1, HIVE1 |
Gene id |
904 |
Description of target |
CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Swissprot id |
O60563 |
Protein accession num |
NP_001231 |
Nucleotide accession num |
NM_001240 |
Protein size |
726 amino acids |
Molecular weight |
81kDa |
Application |
WB |
Partner proteins |
CDK9,CDK9,CDK9,GRN,NCOA2,NUFIP1,tat,vpr,AFF4,AHR,CCNT1,CDK9,ESR1,GRIPAP1,GRN,HEXIM1,HEXIM2,HIC2,HTN1,MYC,NCOA2,NUFIP1,PML,PURA,SKP2,AFF4,AHR,BRD4,CDK9,GRIPAP1,GRN,HEXIM1,HNRNPA1,HTATSF1,MDFIC,MEPCE,MYBL2,MYC,NCOA2,NUFIP1,PGC,PML,PMS1,POLR2A,PURA,SUPT5H |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Sun,J., (2008) J. Virol. 82 (11), 5562-5572 |
Description |
This is a synthetic peptide designed for use in combination with anti-CCNT1 antibody (Catalog #: AVARP03021_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
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Tips |
See our General FAQ page. |
Availability |
In Stock |