CCNT1 Peptide - N-terminal region (AAP30172)

Data Sheet
 
Sku AAP30172
Old sku AAPS08904
Price $99.00
Name CCNT1 Peptide - N-terminal region (AAP30172)
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Size 100 ug
Gene CCNT1
Alias symbols CCNT, CYCT1, HIVE1
Gene id 904
Description of target CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id O60563
Protein accession num NP_001231
Nucleotide accession num NM_001240
Protein size 726 amino acids
Molecular weight 81kDa
Application WB
Partner proteins CDK9,CDK9,CDK9,GRN,NCOA2,NUFIP1,tat,vpr,AFF4,AHR,CCNT1,CDK9,ESR1,GRIPAP1,GRN,HEXIM1,HEXIM2,HIC2,HTN1,MYC,NCOA2,NUFIP1,PML,PURA,SKP2,AFF4,AHR,BRD4,CDK9,GRIPAP1,GRN,HEXIM1,HNRNPA1,HTATSF1,MDFIC,MEPCE,MYBL2,MYC,NCOA2,NUFIP1,PGC,PML,PMS1,POLR2A,PURA,SUPT5H
Quality control The peptide is characterized by mass spectroscopy
Key reference Sun,J., (2008) J. Virol. 82 (11), 5562-5572
Description This is a synthetic peptide designed for use in combination with anti-CCNT1 antibody (Catalog #: AVARP03021_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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