Sku |
AAP30148 |
Old sku |
AAPP00305 |
Price |
$99.00 |
Name |
CDC25A Peptide - middle region (AAP30148) |
Purchase info |
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|
Size |
100 ug |
Gene |
CDC25A |
Alias symbols |
CDC25A2 |
Gene id |
993 |
Description of target |
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. |
Swissprot id |
P30304 |
Protein accession num |
NP_963861 |
Nucleotide accession num |
NM_201567 |
Protein size |
484 amino acids |
Molecular weight |
54kDa |
Application |
WB |
Partner proteins |
E2F1,E2F2,E2F3,E2F4,CHEK1,CHEK1,AR,BTRC,CCNA1,CCNB1,CCNE1,CDK1,CDK2,CDKN3,CHEK1,CHEK2,CUX1,EGFR,FBXW11,HRAS,MAP3K5,NAA10,PIM1,RAF1,ROCK1,SMAD3,UBB,YWHAB,YWHAE,YWHAZ,BTRC,CCNA1,CCNB1,CCNE1,CDK2,CHEK1,CHEK2,EGFR,MAP3K5,MAPK14,NAA10,PIM1,RAF1,ROCK1,UBC,YWHAB,YWHAB,YWHAE,YWHAE,YWHAZ |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Ray,D. (2008) Cancer Res. 68 (5), 1251-1253 |
Description |
This is a synthetic peptide designed for use in combination with anti-CDC25A antibody (Catalog #: AVARP03040_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |