CAV1 Peptide (AAP30144)

Data Sheet
 
Sku AAP30144
Old sku AAPS08602
Price $99.00
Name CAV1 Peptide (AAP30144)
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Size 100 ug
Gene CAV1
Alias symbols CAV, MSTP085, VIP21, CGL3, BSCL3
Gene id 857
Description of target The scaffolding protein is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Swissprot id Q03135
Protein accession num NP_001744
Nucleotide accession num NM_001753
Protein size 178 amino acids
Molecular weight 20kDa
Application IHC, WB
Partner proteins ILK,AR,CAV1,CDH1,PPP1CA,PTEN,PTPN1,PTPN11,PTPN6,PTPRF,ABCB1,ADRBK1,AKAP1,APP,AR,BMX,BSG,BST1,BTK,CAV1,CAV2,CD40,CSK,CSNK2A1,CSNK2A2,DNM1,EDNRB,EGFR,ERBB2,ESR1,FLNA,FLOT2,FYN,GJA1,GJA3,GJB2,GNAI2,GRB7,GRK1,GRK5,HRAS,HTR1F,IGFBP3,ILK,INSR,IRS1,KDR,LRP1,MALL,MAPK1,MAPK3,MMP14,NEU3,NGFR,NOS2,NOS3,NTRK1,PDGFRA,PLD1,PLD2,PRNP,PTEN,PTGS2,PTPN1,PTPN11,PTPN6,PTPRF,RAC1,RCVRN,RHOA,S1PR1,SCP2,SOS1,SRC,STOML3,STRN,STRN4,TGFBR1,TNFRSF1B,TRAF2,TRAF6,TRPC1,ADRBK1,APP,AQP3,AR,BMX,BTK,CAV2,CSK,Clic4,DAG1,EDNRB,EGFR,ESR1,FLOT1,FLOT2,GJA1,GJB1,GJB2,GRK1,GRK5,INSR,NEU3,NGFR,NOS2,NOS3,NTRK1,PDGFRA,PDGFRB,PLD2,PRKACA,PTEN,PTGS2,PTPN1,PTPN11,PTPN6,PTPRF,RCVRN,S1PR1,SCP2,SMAD2,SRC,TGFBR1,TNFRSF1B,TRADD,TRAF2,TRPC1,TSC2
Quality control The peptide is characterized by mass spectroscopy
Key reference Wehner,K.A. Am. J. Physiol., Cell Physiol. 290 (5), C1273-C1274 (2006)
Description This is a synthetic peptide designed for use in combination with anti-CAV1 antibody (Catalog #: AVARP09019_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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Optimal conditions of its use should be determined by end users.

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