wnt pathway Proc FRP Wnt Wif-1 DKK Frizzled CKIE Dvl Axam CK2 GSK-3β PP2A APC β-catenin CKIa PS-1 PKA Protein52 CBP TCF/LEF Xsox17 SMAD4 SMAD3 CtBP c-myc c-jun fra-1 cycD PPAR8 Uterine Nkd P53 Siah-1 SIP APC Cul1 Rbx1 Wnt11 Wnt5 PLC Dvl Daam1 RhoA Rac CaN PKC NFAT Frizzled β-TrCP Frizzled