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Gene ID: 1582 | CYP8B1 Antibody Resource


CYP8B1 Antibody Resource
Gene Full Name: 
cytochrome P450, family 8, subfamily B, polypeptide 1
Uniprot: 
Q9UNU6
Protein Name: 
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Nucleotide: 
NM_004391
Alias: 
CP8B;CYP12;
Ensembl: 
ENSG00000180432
Location: 
3p22.1
HPRD: 
03705
NCBI Gene: 
1582
MIM: 
602172

Summary: 
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]
Function: 
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
Subcellular location: 
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP60138_P050 CYP8B1 antibody - middle region (ARP60138_P050) Polyclonal Human WB 50ug $289 Details
Polyclonal Antibody OAAB05383 CYP8B1 antibody - N-terminal region (OAAB05383) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAAB05384 CYP8B1 antibody - C-terminal region (OAAB05384) Human WB, IHC, FC, ELISA 400ul $289 Details
Polyclonal Antibody ARP60139_P050 CYP8B1 Antibody (ARP60139_P050) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat Not tested 50 ug $125 Details
Polyclonal Antibody OAEC03350 Cytochrome P450 8B1 Antibody (OAEC03350) Human; Mouse WB, IHC, ELISA 100ug $229 Details
Polyclonal Antibody OAAF04623 CYP8B1 Antibody (OAAF04623) Polyclonal Human, Mouse WB, IHC, ELISA 100 ug $229 Details

Show all CYP8B1 antibodies


Product Images
CYP8B1 antibody - middle region (ARP60138_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

CYP8B1 antibody - C-terminal region (OAAB05384) in human hepatocarcinoma cells using Immunohistochemistry

Sample Type: human hepatocarcinoma

CYP8B1 antibody - C-terminal region (OAAB05384) in K562 cells using Western Blot

Sample Type: K562

CYP8B1 antibody - C-terminal region (OAAB05384) in k562 cells using Flow Cytometry

Sample Type: k562

CYP8B1 Antibody (OAAF04623) in 293 cells using Western Blot

Sample Type: 293

CYP8B1 Antibody (OAAF04623) in Human liver carcinoma cells using Immunohistochemistry

Sample Type: Human liver carcinoma

Cytochrome P450 8B1 Antibody (OAEC03350) in 293 cells using Western Blot

Sample Type: 293

Cytochrome P450 8B1 Antibody (OAEC03350) in Human liver carcinoma cells using Immunohistochemistry

Sample Type: Human liver carcinoma


CYP8B1 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60139 Cat CYP8B1 antibody; Felis catus CYP8B1 antibody M3WUJ2 79.0%
ARP60138 Chimpanzee CYP8B1 antibody; Pan troglodytes CYP8B1 antibody H2QMD8 100.0%
ARP60139 Chimpanzee CYP8B1 antibody; Pan troglodytes CYP8B1 antibody H2QMD8 100.0%
ARP60139 Dog CYP8B1 antibody; Canis familiaris CYP8B1 antibody E2RI38 92.0%
ARP44377 Domestic duck CYP8B1 antibody; Anas platyrhynchos CYP8B1 antibody U3HYP3 86.0%
ARP60139 European domestic ferret CYP8B1 antibody; Mustela putorius furo CYP8B1 antibody M3Z6I6 92.0%
ARP60139 Giant panda CYP8B1 antibody; Ailuropoda melanoleuca CYP8B1 antibody G1MLU9 92.0%
ARP60139 Horse CYP8B1 antibody; Equus caballus CYP8B1 antibody F6XMY1 100.0%
ARP60138 Human CYP8B1 antibody; Homo sapiens CYP8B1 antibody C9JFR9 100.0%
ARP60139 Human CYP8B1 antibody; Homo sapiens CYP8B1 antibody C9JFR9 100.0%
ARP60138 Human CYP8B1 antibody; Homo sapiens CYP8B1 antibody Q9UNU6 100.0%
ARP60139 Human CYP8B1 antibody; Homo sapiens CYP8B1 antibody Q9UNU6 100.0%
ARP60139 Mouse CYP8B1 antibody; Mus musculus CYP8B1 antibody O88962 92.0%
ARP60139 Pig CYP8B1 antibody; Sus scrofa CYP8B1 antibody Q7YRB2 86.0%
ARP60139 Rat CYP8B1 antibody; Rattus norvegicus CYP8B1 antibody G3V8J2 92.0%
ARP60139 Rat CYP8B1 antibody; Rattus norvegicus CYP8B1 antibody Q9WVT5 92.0%
ARP60139 Small-eared galago CYP8B1 antibody; Otolemur garnettii CYP8B1 antibody H0WKW8 100.0%
ARP60138 Sumatran orangutan CYP8B1 antibody; Pongo abelii CYP8B1 antibody H2PB18 100.0%
ARP60139 Sumatran orangutan CYP8B1 antibody; Pongo abelii CYP8B1 antibody H2PB18 100.0%
ARP60139 Thirteen-lined ground squirrel CYP8B1 antibody; Spermophilus tridecemlineatus CYP8B1 antibody I3NHL3 79.0%
ARP60139 White-tufted-ear marmoset CYP8B1 antibody; Callithrix jacchus CYP8B1 antibody F7GI78 93.0%
ARP60138 White-tufted-ear marmoset CYP8B1 antibody; Callithrix jacchus CYP8B1 antibody F7GI78 79.0%

Tissue & Cell Line Gene Expression Data