Search Antibody, Protein, and ELISA Kit Solutions


Gene ID: 1594 | CYP27B1 Antibody Resource


CYP27B1 Antibody Resource
Gene Full Name: 
cytochrome P450, family 27, subfamily B, polypeptide 1
Uniprot: 
O15528
Protein Name: 
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Nucleotide: 
NM_000785
Alias: 
VDR;CP2B;CYP1;PDDR;VDD1;VDDR;VDDRI;CYP27B;P450c1;CYP1alpha;
Ensembl: 
ENSG00000111012
Location: 
12q14.1
HPRD: 
02031
NCBI Gene: 
1594
MIM: 
609506

Summary: 
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
Function: 
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
Subcellular location: 
Mitochondrion membrane.
PTM: 
Disease: 
Rickets vitamin D-dependent 1A (VDDR1A) [MIM:264700]: A disorder caused by a selective deficiency of the active form of vitamin D (1,25-dihydroxyvitamin D3) and resulting in defective bone mineralization and clinical features of rickets. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB05644 CYP27B1 antibody - C-terminal region (OAAB05644) Human WB, FC, IHC 400ul $289 Details
Polyclonal Antibody ARP60150_P050 CYP27B1 Antibody (ARP60150_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB08539 CYP27B1 antibody - C - terminal region (OAAB08539) Human WB, IHC 400ul $289 Details

Show all CYP27B1 antibodies


Product Images
CYP27B1 antibody - C-terminal region (OAAB05644) in 293 cells using Flow Cytometry

Sample Type: 293

CYP27B1 antibody - C-terminal region (OAAB05644) in CYP27B1 Antibody (C-term) for immunohistochemistry Clinical relevance has not been evaluated cells using Immunohistochemistry

Sample Type: CYP27B1 Antibody (C-term) for immunohistochemistry Clinical relevance has not been evaluated

CYP27B1 antibody - C-terminal region (OAAB05644) in Mouse Kidney cells using Western Blot

Sample Type: Mouse Kidney

CYP27B1 antibody - C - terminal region (OAAB08539) in Human Kidney cells using Immunohistochemistry

Sample Type: Human Kidney

CYP27B1 antibody - C - terminal region (OAAB08539) in K562 cells using Western Blot

Sample Type: K562


CYP27B1 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60150 Chimpanzee CYP27B1 antibody; Pan troglodytes CYP27B1 antibody H2Q6C4 100.0%
ARP60150 Human CYP27B1 antibody; Homo sapiens CYP27B1 antibody F8VWR7 100.0%
ARP60150 Human CYP27B1 antibody; Homo sapiens CYP27B1 antibody O15528 100.0%
ARP60150 Human CYP27B1 antibody; Homo sapiens CYP27B1 antibody Q548T3 100.0%
ARP60150 Rhesus macaque CYP27B1 antibody; Macaca mulatta CYP27B1 antibody F7H3A6 79.0%
ARP60150 Sumatran orangutan CYP27B1 antibody; Pongo abelii CYP27B1 antibody H2NHV2 93.0%
ARP60150 White-tufted-ear marmoset CYP27B1 antibody; Callithrix jacchus CYP27B1 antibody F7HDX0 79.0%
ARP60150 White-tufted-ear marmoset CYP27B1 antibody; Callithrix jacchus CYP27B1 antibody F7HIZ6 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas205676_at721_B_lymphoblasts6.9005.840Details
BioGPS Gene Atlas205676_atAdipocyte5.5505.840Details
BioGPS Gene Atlas205676_atAdrenalCortex5.9505.840Details
BioGPS Gene Atlas205676_atAdrenalgland4.8005.840Details
BioGPS Gene Atlas205676_atAmygdala6.0505.840Details
BioGPS Gene Atlas205676_atAppendix5.9505.840Details
BioGPS Gene Atlas205676_atAtrioventricularNode4.4505.840Details
BioGPS Gene Atlas205676_atBDCA4+_DentriticCells5.6505.840Details
BioGPS Gene Atlas205676_atBonemarrow5.6505.840Details
BioGPS Gene Atlas205676_atBronchialEpithelialCells12.0005.840Details
BioGPS Gene Atlas205676_atCD105+_Endothelial5.7005.840Details
BioGPS Gene Atlas205676_atCD14+_Monocytes6.0005.840Details
BioGPS Gene Atlas205676_atCD19+_BCells(neg._sel.)5.8005.840Details
BioGPS Gene Atlas205676_atCD33+_Myeloid7.1005.840Details
BioGPS Gene Atlas205676_atCD34+6.8005.840Details
BioGPS Gene Atlas205676_atCD4+_Tcells5.9005.840Details
BioGPS Gene Atlas205676_atCD56+_NKCells6.5005.840Details
BioGPS Gene Atlas205676_atCD71+_EarlyErythroid5.2505.840Details
BioGPS Gene Atlas205676_atCD8+_Tcells5.1005.840Details
BioGPS Gene Atlas205676_atCardiacMyocytes7.4005.840Details
BioGPS Gene Atlas205676_atCaudatenucleus5.1005.840Details
BioGPS Gene Atlas205676_atCerebellum4.6005.840Details
BioGPS Gene Atlas205676_atCerebellumPeduncles6.5005.840Details
BioGPS Gene Atlas205676_atCiliaryGanglion4.0505.840Details
BioGPS Gene Atlas205676_atCingulateCortex5.7005.840Details
BioGPS Gene Atlas205676_atColorectaladenocarcinoma5.8005.840Details
BioGPS Gene Atlas205676_atDorsalRootGanglion4.5005.840Details
BioGPS Gene Atlas205676_atFetalThyroid5.5005.840Details
BioGPS Gene Atlas205676_atFetalbrain6.3505.840Details
BioGPS Gene Atlas205676_atFetalliver4.9505.840Details
BioGPS Gene Atlas205676_atFetallung4.7005.840Details
BioGPS Gene Atlas205676_atGlobusPallidus4.1505.840Details
BioGPS Gene Atlas205676_atHeart7.4005.840Details
BioGPS Gene Atlas205676_atHypothalamus6.2005.840Details
BioGPS Gene Atlas205676_atKidney5.5505.840Details
BioGPS Gene Atlas205676_atLeukemia_chronicMyelogenousK-5625.3005.840Details
BioGPS Gene Atlas205676_atLeukemia_promyelocytic-HL-605.0005.840Details
BioGPS Gene Atlas205676_atLeukemialymphoblastic(MOLT-4)4.5505.840Details
BioGPS Gene Atlas205676_atLiver7.5005.840Details
BioGPS Gene Atlas205676_atLung6.2505.840Details
BioGPS Gene Atlas205676_atLymphnode4.9505.840Details
BioGPS Gene Atlas205676_atLymphoma_burkitts(Daudi)8.3505.840Details
BioGPS Gene Atlas205676_atLymphoma_burkitts(Raji)8.3005.840Details
BioGPS Gene Atlas205676_atMedullaOblongata5.2005.840Details
BioGPS Gene Atlas205676_atOccipitalLobe5.0505.840Details
BioGPS Gene Atlas205676_atOlfactoryBulb4.5005.840Details
BioGPS Gene Atlas205676_atOvary3.9005.840Details
BioGPS Gene Atlas205676_atPancreas4.5005.840Details
BioGPS Gene Atlas205676_atPancreaticIslet6.1005.840Details
BioGPS Gene Atlas205676_atParietalLobe6.1505.840Details
BioGPS Gene Atlas205676_atPituitary6.6005.840Details
BioGPS Gene Atlas205676_atPlacenta5.8005.840Details
BioGPS Gene Atlas205676_atPons5.4505.840Details
BioGPS Gene Atlas205676_atPrefrontalCortex7.0505.840Details
BioGPS Gene Atlas205676_atProstate6.6005.840Details
BioGPS Gene Atlas205676_atSalivarygland5.1005.840Details
BioGPS Gene Atlas205676_atSkeletalMuscle6.7005.840Details
BioGPS Gene Atlas205676_atSkin4.5505.840Details
BioGPS Gene Atlas205676_atSmoothMuscle6.4005.840Details
BioGPS Gene Atlas205676_atSpinalcord6.1005.840Details
BioGPS Gene Atlas205676_atSubthalamicNucleus5.1505.840Details
BioGPS Gene Atlas205676_atSuperiorCervicalGanglion7.1005.840Details
BioGPS Gene Atlas205676_atTemporalLobe5.2005.840Details
BioGPS Gene Atlas205676_atTestis4.8505.840Details
BioGPS Gene Atlas205676_atTestisGermCell4.7005.840Details
BioGPS Gene Atlas205676_atTestisIntersitial4.7505.840Details
BioGPS Gene Atlas205676_atTestisLeydigCell5.6505.840Details
BioGPS Gene Atlas205676_atTestisSeminiferousTubule4.8505.840Details
BioGPS Gene Atlas205676_atThalamus5.7505.840Details
BioGPS Gene Atlas205676_atThymus4.4505.840Details
BioGPS Gene Atlas205676_atThyroid7.3505.840Details
BioGPS Gene Atlas205676_atTongue5.8005.840Details
BioGPS Gene Atlas205676_atTonsil5.5505.840Details
BioGPS Gene Atlas205676_atTrachea4.7505.840Details
BioGPS Gene Atlas205676_atTrigeminalGanglion5.8505.840Details
BioGPS Gene Atlas205676_atUterus4.7005.840Details
BioGPS Gene Atlas205676_atUterusCorpus5.1505.840Details
BioGPS Gene Atlas205676_atWholeBlood6.2005.840Details
BioGPS Gene Atlas205676_atWholebrain4.9505.840Details
BioGPS Gene Atlas205676_atcolon5.6505.840Details
BioGPS Gene Atlas205676_atpineal_day6.9805.840Details
BioGPS Gene Atlas205676_atpineal_night6.8205.840Details
BioGPS Gene Atlas205676_atretina6.8755.840Details
BioGPS Gene Atlas205676_atsmall_intestine5.4005.840Details
BioGPS NCI60205676_at7864.4474.930Details
BioGPS NCI60205676_atA1724.3894.930Details
BioGPS NCI60205676_atA2044.8394.930Details
BioGPS NCI60205676_atA3614.4394.930Details
BioGPS NCI60205676_atA4984.3354.930Details
BioGPS NCI60205676_atA5494.4154.930Details
BioGPS NCI60205676_atACC35.6224.930Details
BioGPS NCI60205676_atACHN4.1564.930Details
BioGPS NCI60205676_atALVA314.5364.930Details
BioGPS NCI60205676_atCAKI14.4354.930Details
BioGPS NCI60205676_atCCRT CEM4.6964.930Details
BioGPS NCI60205676_atCOLO2055.1624.930Details
BioGPS NCI60205676_atDLD16.1094.930Details
BioGPS NCI60205676_atDU1454.6934.930Details
BioGPS NCI60205676_atEKVX4.3884.930Details
BioGPS NCI60205676_atGM1334.4774.930Details
BioGPS NCI60205676_atGM16004.5214.930Details
BioGPS NCI60205676_atGM23134.4464.930Details
BioGPS NCI60205676_atGM23454.3994.930Details
BioGPS NCI60205676_atGM24934.6164.930Details
BioGPS NCI60205676_atGM974.7274.930Details
BioGPS NCI60205676_atHCC29984.0544.930Details
BioGPS NCI60205676_atHCT1167.4314.930Details
BioGPS NCI60205676_atHCT156.5714.930Details
BioGPS NCI60205676_atHEK 293 T-rex5.4374.930Details
BioGPS NCI60205676_atHEK 293T11.5894.930Details
BioGPS NCI60205676_atHEK2939.2074.930Details
BioGPS NCI60205676_atHELA4.1644.930Details
BioGPS NCI60205676_atHEPG24.6474.930Details
BioGPS NCI60205676_atHL604.5614.930Details
BioGPS NCI60205676_atHOP624.3484.930Details
BioGPS NCI60205676_atHOP924.2804.930Details
BioGPS NCI60205676_atHS578T4.2814.930Details
BioGPS NCI60205676_atHSG4.3364.930Details
BioGPS NCI60205676_atHT10804.3714.930Details
BioGPS NCI60205676_atHT294.6784.930Details
BioGPS NCI60205676_atIGROV14.3084.930Details
BioGPS NCI60205676_atIOSE804.3234.930Details
BioGPS NCI60205676_atJURKAT4.7304.930Details
BioGPS NCI60205676_atK5624.6674.930Details
BioGPS NCI60205676_atKM124.4774.930Details
BioGPS NCI60205676_atLN184.1684.930Details
BioGPS NCI60205676_atLNCAP4.3834.930Details
BioGPS NCI60205676_atLOX IMVI4.9564.930Details
BioGPS NCI60205676_atM144.3484.930Details
BioGPS NCI60205676_atMALME 3M4.4144.930Details
BioGPS NCI60205676_atMCF74.3924.930Details
BioGPS NCI60205676_atMD MB2314.4374.930Details
BioGPS NCI60205676_atMDA MB4354.4804.930Details
BioGPS NCI60205676_atMOLT44.4884.930Details
BioGPS NCI60205676_atNCI 4604.5064.930Details
BioGPS NCI60205676_atNCI H2264.3774.930Details
BioGPS NCI60205676_atNCI H234.4154.930Details
BioGPS NCI60205676_atNCI H322M4.8074.930Details
BioGPS NCI60205676_atNCVADR RES4.2504.930Details
BioGPS NCI60205676_atOVCAR34.5954.930Details
BioGPS NCI60205676_atOVCAR44.3574.930Details
BioGPS NCI60205676_atOVCAR54.2904.930Details
BioGPS NCI60205676_atOVCAR84.1684.930Details
BioGPS NCI60205676_atPANC14.4774.930Details
BioGPS NCI60205676_atRL74.4504.930Details
BioGPS NCI60205676_atRPMI 82266.8194.930Details
BioGPS NCI60205676_atRS118464.8654.930Details
BioGPS NCI60205676_atRXF3934.3694.930Details
BioGPS NCI60205676_atSAOS24.4284.930Details
BioGPS NCI60205676_atSF2684.3634.930Details
BioGPS NCI60205676_atSF2954.2954.930Details
BioGPS NCI60205676_atSF5394.1984.930Details
BioGPS NCI60205676_atSHSYSY+RA4.2104.930Details
BioGPS NCI60205676_atSHSYSY-RA4.3024.930Details
BioGPS NCI60205676_atSKMEL24.3324.930Details
BioGPS NCI60205676_atSKMEL284.3824.930Details
BioGPS NCI60205676_atSKMEL54.2074.930Details
BioGPS NCI60205676_atSKOV34.3654.930Details
BioGPS NCI60205676_atSN12C4.3624.930Details
BioGPS NCI60205676_atSNB194.1144.930Details
BioGPS NCI60205676_atSNB754.3364.930Details
BioGPS NCI60205676_atSR4.6634.930Details
BioGPS NCI60205676_atSW6204.4374.930Details
BioGPS NCI60205676_atT244.9314.930Details
BioGPS NCI60205676_atT3M44.7574.930Details
BioGPS NCI60205676_atTK104.3784.930Details
BioGPS NCI60205676_atU1184.2744.930Details
BioGPS NCI60205676_atU1384.1784.930Details
BioGPS NCI60205676_atU20S8.0474.930Details
BioGPS NCI60205676_atU2514.3834.930Details
BioGPS NCI60205676_atU874.2334.930Details
BioGPS NCI60205676_atUACC2574.3234.930Details
BioGPS NCI60205676_atUACC624.4484.930Details
BioGPS NCI60205676_atUO314.2134.930Details
BioGPS NCI60205676_atZR75_112.0464.930Details
BioGPS NCI60205676_atastrocytes4.5144.930Details
BioGPS NCI60205676_athuh-74.5984.930Details