Search Antibody, Protein, and ELISA Kit Solutions


Gene ID: 1585 | CYP11B2 Antibody Resource


CYP11B2 Antibody Resource
Gene Full Name: 
cytochrome P450, family 11, subfamily B, polypeptide 2
Uniprot: 
P19099
Protein Name: 
cytochrome P450 11B2, mitochondrial
Nucleotide: 
NM_000498
Alias: 
CPN2;ALDOS;CYP11B;CYP11BL;CYPXIB2;P450C18;P-450C18;P450aldo;
Ensembl: 
ENSG00000179142
Location: 
8q21-q22
HPRD: 
00492
NCBI Gene: 
1585
MIM: 
124080

Summary: 
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
Function: 
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
Subcellular location: 
Mitochondrion membrane.
PTM: 
Disease: 
Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) [MIM:203400]: Autosomal recessive disorder of aldosterone biosynthesis. There are two biochemically different forms of selective aldosterone deficiency be termed corticosterone methyloxidase (CMO) deficiency type 1 and type 2. In CMO-1 deficiency, aldosterone is undetectable in plasma, while its immediate precursor, 18-hydroxycorticosterone, is low or normal. Note: The disease is caused by mutations affecting the gene represented in this entry. Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency) [MIM:610600]: Autosomal recessive disorder of aldosterone biosynthesis. In CMO-2 deficiency, aldosterone can be low or normal, but at the expense of increased secretion of 18-hydroxycorticosterone. Consequently, patients have a greatly increased ratio of 18-hydroxycorticosterone to aldosterone and a low ratio of corticosterone to 18-hydroxycorticosterone in serum. Note: The disease is caused by mutations affecting the gene represented in this entry. Familial hyperaldosteronism 1 (FH1) [MIM:103900]: A disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol. There is significant phenotypic heterogeneity, and some individuals never develop hypertension. Note: The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP41750_P050 CYP11B2 antibody - middle region (ARP41750_P050) Polyclonal Human WB 50ug $289 Details
Polyclonal Antibody ARP41749_P050 CYP11B2 Antibody (ARP41749_P050) Polyclonal Dog, Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB07456 CYP11B2 antibody - center region (OAAB07456) Human; Mouse WB, IHC, FC 400ul $289 Details

Show all CYP11B2 antibodies


Product Images
CYP11B2 antibody - middle region (ARP41750_P050) in Human OVCAR3 cells using Western Blot

Sample Type: Human OVCAR3

CYP11B2 antibody - middle region (ARP41750_P050) in transfected HEK293-CYP11B2 cells using Western Blot

Sample Type: transfected HEK293-CYP11B2

CYP11B2 antibody - center region (OAAB07456) in CEM cells using Western Blot

Sample Type: CEM


CYP11B2 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60141 Chimpanzee CYP11B2 antibody; Pan troglodytes CYP11B2 antibody H2QWT3 100.0%
ARP41750 Chimpanzee CYP11B2 antibody; Pan troglodytes CYP11B2 antibody H2QWT3 93.0%
ARP41749 Dog CYP11B2 antibody; Canis familiaris CYP11B2 antibody F1PNC7 79.0%
ARP41749 Human CYP11B2 antibody; Homo sapiens CYP11B2 antibody P19099 100.0%
ARP41750 Human CYP11B2 antibody; Homo sapiens CYP11B2 antibody P19099 100.0%
ARP60140 Human CYP11B2 antibody; Homo sapiens CYP11B2 antibody P19099 100.0%
ARP60141 Human CYP11B2 antibody; Homo sapiens CYP11B2 antibody P19099 100.0%
ARP41749 Human CYP11B2 antibody; Homo sapiens CYP11B2 antibody Q16316 100.0%
ARP60140 Human CYP11B2 antibody; Homo sapiens CYP11B2 antibody Q16316 100.0%
ARP60141 Human CYP11B2 antibody; Homo sapiens CYP11B2 antibody Q16316 100.0%
ARP60140 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F6QXV6 100.0%
ARP60140 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7A4J7 100.0%
ARP60140 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7GMV0 100.0%
ARP60140 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7GMV4 100.0%
ARP41749 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F6QXV6 93.0%
ARP41750 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F6QXV6 93.0%
ARP60141 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7A4J7 93.0%
ARP60141 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7GMV0 93.0%
ARP60141 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7GMV4 93.0%
ARP60141 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F6QXV6 86.0%
ARP41750 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7A4J7 86.0%
ARP41750 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7GMV0 86.0%
ARP41750 Rhesus macaque CYP11B2 antibody; Macaca mulatta CYP11B2 antibody F7GMV4 86.0%
ARP41749 Sumatran orangutan CYP11B2 antibody; Pongo abelii CYP11B2 antibody H2PRC0 100.0%
ARP60140 Sumatran orangutan CYP11B2 antibody; Pongo abelii CYP11B2 antibody H2PRC0 100.0%
ARP60141 Sumatran orangutan CYP11B2 antibody; Pongo abelii CYP11B2 antibody H2PRC0 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas214630_at721_B_lymphoblasts8.25014.630Details
BioGPS Gene Atlas214630_atAdipocyte8.40014.630Details
BioGPS Gene Atlas214630_atAdrenalCortex486.60014.630Details
BioGPS Gene Atlas214630_atAdrenalgland115.55014.630Details
BioGPS Gene Atlas214630_atAmygdala7.00014.630Details
BioGPS Gene Atlas214630_atAppendix8.55014.630Details
BioGPS Gene Atlas214630_atAtrioventricularNode14.35014.630Details
BioGPS Gene Atlas214630_atBDCA4+_DentriticCells7.45014.630Details
BioGPS Gene Atlas214630_atBonemarrow7.00014.630Details
BioGPS Gene Atlas214630_atBronchialEpithelialCells5.95014.630Details
BioGPS Gene Atlas214630_atCD105+_Endothelial7.00014.630Details
BioGPS Gene Atlas214630_atCD14+_Monocytes6.65014.630Details
BioGPS Gene Atlas214630_atCD19+_BCells(neg._sel.)7.40014.630Details
BioGPS Gene Atlas214630_atCD33+_Myeloid9.05014.630Details
BioGPS Gene Atlas214630_atCD34+8.75014.630Details
BioGPS Gene Atlas214630_atCD4+_Tcells7.25014.630Details
BioGPS Gene Atlas214630_atCD56+_NKCells7.45014.630Details
BioGPS Gene Atlas214630_atCD71+_EarlyErythroid6.70014.630Details
BioGPS Gene Atlas214630_atCD8+_Tcells6.00014.630Details
BioGPS Gene Atlas214630_atCardiacMyocytes8.65014.630Details
BioGPS Gene Atlas214630_atCaudatenucleus7.25014.630Details
BioGPS Gene Atlas214630_atCerebellum5.80014.630Details
BioGPS Gene Atlas214630_atCerebellumPeduncles18.80014.630Details
BioGPS Gene Atlas214630_atCiliaryGanglion15.25014.630Details
BioGPS Gene Atlas214630_atCingulateCortex13.05014.630Details
BioGPS Gene Atlas214630_atColorectaladenocarcinoma6.80014.630Details
BioGPS Gene Atlas214630_atDorsalRootGanglion11.35014.630Details
BioGPS Gene Atlas214630_atFetalThyroid7.05014.630Details
BioGPS Gene Atlas214630_atFetalbrain7.25014.630Details
BioGPS Gene Atlas214630_atFetalliver5.55014.630Details
BioGPS Gene Atlas214630_atFetallung5.05014.630Details
BioGPS Gene Atlas214630_atGlobusPallidus5.85014.630Details
BioGPS Gene Atlas214630_atHeart8.85014.630Details
BioGPS Gene Atlas214630_atHypothalamus7.70014.630Details
BioGPS Gene Atlas214630_atKidney6.40014.630Details
BioGPS Gene Atlas214630_atLeukemia_chronicMyelogenousK-5627.00014.630Details
BioGPS Gene Atlas214630_atLeukemia_promyelocytic-HL-606.35014.630Details
BioGPS Gene Atlas214630_atLeukemialymphoblastic(MOLT-4)7.00014.630Details
BioGPS Gene Atlas214630_atLiver9.30014.630Details
BioGPS Gene Atlas214630_atLung6.75014.630Details
BioGPS Gene Atlas214630_atLymphnode6.10014.630Details
BioGPS Gene Atlas214630_atLymphoma_burkitts(Daudi)9.60014.630Details
BioGPS Gene Atlas214630_atLymphoma_burkitts(Raji)8.20014.630Details
BioGPS Gene Atlas214630_atMedullaOblongata6.65014.630Details
BioGPS Gene Atlas214630_atOccipitalLobe7.40014.630Details
BioGPS Gene Atlas214630_atOlfactoryBulb6.95014.630Details
BioGPS Gene Atlas214630_atOvary5.70014.630Details
BioGPS Gene Atlas214630_atPancreas5.95014.630Details
BioGPS Gene Atlas214630_atPancreaticIslet7.65014.630Details
BioGPS Gene Atlas214630_atParietalLobe8.25014.630Details
BioGPS Gene Atlas214630_atPituitary8.60014.630Details
BioGPS Gene Atlas214630_atPlacenta6.95014.630Details
BioGPS Gene Atlas214630_atPons13.00014.630Details
BioGPS Gene Atlas214630_atPrefrontalCortex8.45014.630Details
BioGPS Gene Atlas214630_atProstate8.00014.630Details
BioGPS Gene Atlas214630_atSalivarygland6.10014.630Details
BioGPS Gene Atlas214630_atSkeletalMuscle9.25014.630Details
BioGPS Gene Atlas214630_atSkin6.95014.630Details
BioGPS Gene Atlas214630_atSmoothMuscle7.80014.630Details
BioGPS Gene Atlas214630_atSpinalcord9.45014.630Details
BioGPS Gene Atlas214630_atSubthalamicNucleus21.00014.630Details
BioGPS Gene Atlas214630_atSuperiorCervicalGanglion9.45014.630Details
BioGPS Gene Atlas214630_atTemporalLobe7.85014.630Details
BioGPS Gene Atlas214630_atTestis6.20014.630Details
BioGPS Gene Atlas214630_atTestisGermCell5.70014.630Details
BioGPS Gene Atlas214630_atTestisIntersitial6.15014.630Details
BioGPS Gene Atlas214630_atTestisLeydigCell7.30014.630Details
BioGPS Gene Atlas214630_atTestisSeminiferousTubule8.35014.630Details
BioGPS Gene Atlas214630_atThalamus13.60014.630Details
BioGPS Gene Atlas214630_atThymus5.25014.630Details
BioGPS Gene Atlas214630_atThyroid6.65014.630Details
BioGPS Gene Atlas214630_atTongue8.15014.630Details
BioGPS Gene Atlas214630_atTonsil7.85014.630Details
BioGPS Gene Atlas214630_atTrachea5.80014.630Details
BioGPS Gene Atlas214630_atTrigeminalGanglion8.95014.630Details
BioGPS Gene Atlas214630_atUterus4.70014.630Details
BioGPS Gene Atlas214630_atUterusCorpus6.25014.630Details
BioGPS Gene Atlas214630_atWholeBlood7.45014.630Details
BioGPS Gene Atlas214630_atWholebrain5.70014.630Details
BioGPS Gene Atlas214630_atcolon5.20014.630Details
BioGPS Gene Atlas214630_atpineal_day8.68014.630Details
BioGPS Gene Atlas214630_atpineal_night7.68014.630Details
BioGPS Gene Atlas214630_atretina7.45014.630Details
BioGPS Gene Atlas214630_atsmall_intestine5.05014.630Details
BioGPS NCI60214630_at7863.2863.370Details
BioGPS NCI60214630_atA1723.1083.370Details
BioGPS NCI60214630_atA2043.2313.370Details
BioGPS NCI60214630_atA3613.2943.370Details
BioGPS NCI60214630_atA4983.2763.370Details
BioGPS NCI60214630_atA5493.3013.370Details
BioGPS NCI60214630_atACC33.3543.370Details
BioGPS NCI60214630_atACHN3.1633.370Details
BioGPS NCI60214630_atALVA313.8513.370Details
BioGPS NCI60214630_atCAKI13.5403.370Details
BioGPS NCI60214630_atCCRT CEM5.7593.370Details
BioGPS NCI60214630_atCOLO2053.2473.370Details
BioGPS NCI60214630_atDLD13.2363.370Details
BioGPS NCI60214630_atDU1453.1933.370Details
BioGPS NCI60214630_atEKVX3.2133.370Details
BioGPS NCI60214630_atGM1333.2913.370Details
BioGPS NCI60214630_atGM16003.3083.370Details
BioGPS NCI60214630_atGM23133.2663.370Details
BioGPS NCI60214630_atGM23453.2463.370Details
BioGPS NCI60214630_atGM24933.3113.370Details
BioGPS NCI60214630_atGM973.4013.370Details
BioGPS NCI60214630_atHCC29983.1203.370Details
BioGPS NCI60214630_atHCT1163.2493.370Details
BioGPS NCI60214630_atHCT153.1283.370Details
BioGPS NCI60214630_atHEK 293 T-rex3.2963.370Details
BioGPS NCI60214630_atHEK 293T3.2613.370Details
BioGPS NCI60214630_atHEK2933.2283.370Details
BioGPS NCI60214630_atHELA3.1833.370Details
BioGPS NCI60214630_atHEPG23.3773.370Details
BioGPS NCI60214630_atHL606.3623.370Details
BioGPS NCI60214630_atHOP623.2803.370Details
BioGPS NCI60214630_atHOP923.2343.370Details
BioGPS NCI60214630_atHS578T3.2513.370Details
BioGPS NCI60214630_atHSG3.2033.370Details
BioGPS NCI60214630_atHT10803.2583.370Details
BioGPS NCI60214630_atHT293.3523.370Details
BioGPS NCI60214630_atIGROV13.2433.370Details
BioGPS NCI60214630_atIOSE803.2783.370Details
BioGPS NCI60214630_atJURKAT3.2603.370Details
BioGPS NCI60214630_atK5623.3663.370Details
BioGPS NCI60214630_atKM123.3423.370Details
BioGPS NCI60214630_atLN183.0943.370Details
BioGPS NCI60214630_atLNCAP3.2613.370Details
BioGPS NCI60214630_atLOX IMVI3.2613.370Details
BioGPS NCI60214630_atM143.2463.370Details
BioGPS NCI60214630_atMALME 3M3.5243.370Details
BioGPS NCI60214630_atMCF73.1313.370Details
BioGPS NCI60214630_atMD MB2313.2843.370Details
BioGPS NCI60214630_atMDA MB4353.5933.370Details
BioGPS NCI60214630_atMOLT43.7203.370Details
BioGPS NCI60214630_atNCI 4603.3153.370Details
BioGPS NCI60214630_atNCI H2263.3183.370Details
BioGPS NCI60214630_atNCI H233.3053.370Details
BioGPS NCI60214630_atNCI H322M3.2823.370Details
BioGPS NCI60214630_atNCVADR RES3.2113.370Details
BioGPS NCI60214630_atOVCAR33.3653.370Details
BioGPS NCI60214630_atOVCAR43.2513.370Details
BioGPS NCI60214630_atOVCAR53.2413.370Details
BioGPS NCI60214630_atOVCAR83.0833.370Details
BioGPS NCI60214630_atPANC13.2863.370Details
BioGPS NCI60214630_atRL73.3103.370Details
BioGPS NCI60214630_atRPMI 82263.2903.370Details
BioGPS NCI60214630_atRS118463.4823.370Details
BioGPS NCI60214630_atRXF3933.2863.370Details
BioGPS NCI60214630_atSAOS23.3003.370Details
BioGPS NCI60214630_atSF2683.2723.370Details
BioGPS NCI60214630_atSF2953.2153.370Details
BioGPS NCI60214630_atSF5393.9053.370Details
BioGPS NCI60214630_atSHSYSY+RA3.2063.370Details
BioGPS NCI60214630_atSHSYSY-RA3.2093.370Details
BioGPS NCI60214630_atSKMEL23.2633.370Details
BioGPS NCI60214630_atSKMEL283.2743.370Details
BioGPS NCI60214630_atSKMEL53.1703.370Details
BioGPS NCI60214630_atSKOV33.2993.370Details
BioGPS NCI60214630_atSN12C3.2353.370Details
BioGPS NCI60214630_atSNB193.1743.370Details
BioGPS NCI60214630_atSNB753.2763.370Details
BioGPS NCI60214630_atSR3.5903.370Details
BioGPS NCI60214630_atSW6203.2553.370Details
BioGPS NCI60214630_atT243.2923.370Details
BioGPS NCI60214630_atT3M43.3413.370Details
BioGPS NCI60214630_atTK103.2553.370Details
BioGPS NCI60214630_atU1183.2453.370Details
BioGPS NCI60214630_atU1383.1253.370Details
BioGPS NCI60214630_atU20S3.2493.370Details
BioGPS NCI60214630_atU2513.2533.370Details
BioGPS NCI60214630_atU873.1563.370Details
BioGPS NCI60214630_atUACC2573.2403.370Details
BioGPS NCI60214630_atUACC623.3003.370Details
BioGPS NCI60214630_atUO313.1893.370Details
BioGPS NCI60214630_atZR75_13.6433.370Details
BioGPS NCI60214630_atastrocytes3.3143.370Details
BioGPS NCI60214630_athuh-73.3343.370Details