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Gene ID: 8454 | CUL1 Antibody Resource


CUL1 Antibody Resource
Gene Full Name: 
cullin 1
Uniprot: 
Q13616
Protein Name: 
cullin-1
Nucleotide: 
XM_005250060
Alias: 
Ensembl: 
ENSG00000055130
Location: 
7q36.1
HPRD: 
04389
NCBI Gene: 
8454
MIM: 
603134

Summary: 
Function: 
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2.
Subcellular location: 
PTM: 
Isopeptide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody AVARP03049_T100 CUL1 antibody - C-terminal region (AVARP03049_T100) Polyclonal Bovine, Dog, Human, Mouse, Rat, Zebrafish WB 100ug $229 Details
Polyclonal Antibody OAMA03254 Rabbit anti Cul1 (a.a. 766-776) Antibody (0.1ml) ELISA, IP, WB 0.1ml $725 Details
Protein OPPA02515 CUL1 Human - Recombinant Human Cullin-1 (2ug) 2ug $100 Details
Polyclonal Antibody OARA03213 CUL1 antibody - C-terminal region (OARA03213) Human ELISA, WB, IHC 100 ul $475 Details
Polyclonal Antibody OAAB11734 CUL1 antibody - C - terminal region (OAAB11734) Human WB 400ul $289 Details
Polyclonal Antibody OAEC01596 Cullin 1 Antibody (OAEC01596) Human; Mouse WB, IHC, IF, ELISA 100ug $229 Details
Polyclonal Antibody OAAF01765 CUL1 Antibody (OAAF01765) Polyclonal Human, Mouse WB, IHC, IF, ELISA 100 ug $229 Details

Show all CUL1 antibodies


Product Images
CUL1 antibody - C-terminal region (AVARP03049_T100) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

CUL1 antibody - C - terminal region (OAAB11734) in Hela cells using Western Blot

Sample Type: Hela

CUL1 Antibody (OAAF01765) in CoLo , 3T3 cells using Western Blot

Sample Type: CoLo , 3T3

CUL1 Antibody (OAAF01765) in HeLa cells using Western Blot

Sample Type: HeLa

CUL1 Antibody (OAAF01765) in HeLa cells using Immunofluorescence

Sample Type: HeLa

CUL1 Antibody (OAAF01765) in Human lung carcinoma cells using Immunohistochemistry

Sample Type: Human lung carcinoma

Cullin 1 Antibody (OAEC01596) in Human Hela cells using Immunofluorescence

Sample Type: Human Hela

Cullin 1 Antibody (OAEC01596) in Human Hela cells using Western Blot

Sample Type: Human Hela

Cullin 1 Antibody (OAEC01596) in Human lung carcinoma cells using Immunohistochemistry

Sample Type: Human lung carcinoma


CUL1 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30437 African clawed frog CUL1 antibody; Xenopus laevis CUL1 antibody Q566I2 100.0%
ARP30437 Bovine CUL1 antibody; Bos taurus CUL1 antibody F1MYD0 100.0%
ARP30437 Bovine CUL1 antibody; Bos taurus CUL1 antibody G3N0Q3 100.0%
ARP30437 Cat CUL1 antibody; Felis catus CUL1 antibody M3W9W6 100.0%
ARP30437 Cat CUL1 antibody; Felis catus CUL1 antibody M3XAR4 100.0%
ARP30437 Chimpanzee CUL1 antibody; Pan troglodytes CUL1 antibody G2HEC7 100.0%
ARP30437 Chinese softshell turtle CUL1 antibody; Pelodiscus sinensis CUL1 antibody K7GBF3 100.0%
ARP30437 Dog CUL1 antibody; Canis familiaris CUL1 antibody E2R1V2 100.0%
ARP30437 Duckbill platypus CUL1 antibody; Ornithorhynchus anatinus CUL1 antibody F6X2V7 100.0%
ARP30437 Giant panda CUL1 antibody; Ailuropoda melanoleuca CUL1 antibody G1L854 100.0%
ARP30437 Gray short-tailed opossum CUL1 antibody; Monodelphis domestica CUL1 antibody F6T584 100.0%
ARP30437 Horse CUL1 antibody; Equus caballus CUL1 antibody F6SGJ7 100.0%
ARP30437 Human CUL1 antibody; Homo sapiens CUL1 antibody Q75MQ1 100.0%
ARP30437 Human CUL1 antibody; Homo sapiens CUL1 antibody Q13616 100.0%
ARP30437 Hydra CUL1 antibody; Hydra vulgaris CUL1 antibody T2ME24 91.0%
ARP30437 Mouse CUL1 antibody; Mus musculus CUL1 antibody Q9WTX6 100.0%
ARP30437 Mouse CUL1 antibody; Mus musculus CUL1 antibody Q3UIA5 100.0%
ARP30437 Northern white-cheeked gibbon CUL1 antibody; Nomascus leucogenys CUL1 antibody G1QTR6 100.0%
ARP30437 Parasitic wasp CUL1 antibody; Nasonia vitripennis CUL1 antibody K7IRN2 82.0%
ARP30437 Pig CUL1 antibody; Sus scrofa CUL1 antibody F1SAD7 100.0%
ARP30437 Rabbit CUL1 antibody; Oryctolagus cuniculus CUL1 antibody G1SHS4 100.0%
ARP30437 Rat CUL1 antibody; Rattus norvegicus CUL1 antibody B1WBY1 100.0%
ARP30437 Rhesus macaque CUL1 antibody; Macaca mulatta CUL1 antibody H9G0U2 100.0%
ARP30437 Small-eared galago CUL1 antibody; Otolemur garnettii CUL1 antibody H0XBT6 100.0%
ARP30437 Spotted green pufferfish CUL1 antibody; Tetraodon nigroviridis CUL1 antibody H3CA40 100.0%
ARP30437 Sumatran orangutan CUL1 antibody; Pongo abelii CUL1 antibody Q5R4G6 100.0%
ARP30437 Tasmanian devil CUL1 antibody; Sarcophilus harrisii CUL1 antibody G3WZI9 100.0%
ARP30437 Thirteen-lined ground squirrel CUL1 antibody; Spermophilus tridecemlineatus CUL1 antibody I3M702 100.0%
ARP30437 Western clawed frog CUL1 antibody; Xenopus tropicalis CUL1 antibody Q1KMU1 100.0%
ARP30437 White-tufted-ear marmoset CUL1 antibody; Callithrix jacchus CUL1 antibody U3CZT1 100.0%
ARP30437 Zebra finch CUL1 antibody; Taeniopygia guttata CUL1 antibody H0YU78 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207614_s_at721_B_lymphoblasts162.25060.700Details
BioGPS Gene Atlas207614_s_atAdipocyte32.40060.700Details
BioGPS Gene Atlas207614_s_atAdrenalCortex24.70060.700Details
BioGPS Gene Atlas207614_s_atAdrenalgland15.40060.700Details
BioGPS Gene Atlas207614_s_atAmygdala42.40060.700Details
BioGPS Gene Atlas207614_s_atAppendix28.85060.700Details
BioGPS Gene Atlas207614_s_atAtrioventricularNode18.60060.700Details
BioGPS Gene Atlas207614_s_atBDCA4+_DentriticCells82.60060.700Details
BioGPS Gene Atlas207614_s_atBonemarrow21.65060.700Details
BioGPS Gene Atlas207614_s_atBronchialEpithelialCells110.80060.700Details
BioGPS Gene Atlas207614_s_atCD105+_Endothelial43.05060.700Details
BioGPS Gene Atlas207614_s_atCD14+_Monocytes92.75060.700Details
BioGPS Gene Atlas207614_s_atCD19+_BCells(neg._sel.)100.20060.700Details
BioGPS Gene Atlas207614_s_atCD33+_Myeloid93.35060.700Details
BioGPS Gene Atlas207614_s_atCD34+106.80060.700Details
BioGPS Gene Atlas207614_s_atCD4+_Tcells126.85060.700Details
BioGPS Gene Atlas207614_s_atCD56+_NKCells82.80060.700Details
BioGPS Gene Atlas207614_s_atCD71+_EarlyErythroid40.15060.700Details
BioGPS Gene Atlas207614_s_atCD8+_Tcells174.55060.700Details
BioGPS Gene Atlas207614_s_atCardiacMyocytes42.60060.700Details
BioGPS Gene Atlas207614_s_atCaudatenucleus27.15060.700Details
BioGPS Gene Atlas207614_s_atCerebellum24.05060.700Details
BioGPS Gene Atlas207614_s_atCerebellumPeduncles38.65060.700Details
BioGPS Gene Atlas207614_s_atCiliaryGanglion23.95060.700Details
BioGPS Gene Atlas207614_s_atCingulateCortex34.30060.700Details
BioGPS Gene Atlas207614_s_atColorectaladenocarcinoma78.55060.700Details
BioGPS Gene Atlas207614_s_atDorsalRootGanglion17.40060.700Details
BioGPS Gene Atlas207614_s_atFetalThyroid36.90060.700Details
BioGPS Gene Atlas207614_s_atFetalbrain37.70060.700Details
BioGPS Gene Atlas207614_s_atFetalliver27.45060.700Details
BioGPS Gene Atlas207614_s_atFetallung31.85060.700Details
BioGPS Gene Atlas207614_s_atGlobusPallidus24.90060.700Details
BioGPS Gene Atlas207614_s_atHeart37.60060.700Details
BioGPS Gene Atlas207614_s_atHypothalamus49.05060.700Details
BioGPS Gene Atlas207614_s_atKidney6.15060.700Details
BioGPS Gene Atlas207614_s_atLeukemia_chronicMyelogenousK-56258.65060.700Details
BioGPS Gene Atlas207614_s_atLeukemia_promyelocytic-HL-6057.35060.700Details
BioGPS Gene Atlas207614_s_atLeukemialymphoblastic(MOLT-4)40.80060.700Details
BioGPS Gene Atlas207614_s_atLiver38.25060.700Details
BioGPS Gene Atlas207614_s_atLung26.45060.700Details
BioGPS Gene Atlas207614_s_atLymphnode31.10060.700Details
BioGPS Gene Atlas207614_s_atLymphoma_burkitts(Daudi)144.00060.700Details
BioGPS Gene Atlas207614_s_atLymphoma_burkitts(Raji)46.05060.700Details
BioGPS Gene Atlas207614_s_atMedullaOblongata27.25060.700Details
BioGPS Gene Atlas207614_s_atOccipitalLobe33.90060.700Details
BioGPS Gene Atlas207614_s_atOlfactoryBulb19.85060.700Details
BioGPS Gene Atlas207614_s_atOvary28.15060.700Details
BioGPS Gene Atlas207614_s_atPancreas22.95060.700Details
BioGPS Gene Atlas207614_s_atPancreaticIslet35.45060.700Details
BioGPS Gene Atlas207614_s_atParietalLobe40.00060.700Details
BioGPS Gene Atlas207614_s_atPituitary42.80060.700Details
BioGPS Gene Atlas207614_s_atPlacenta37.70060.700Details
BioGPS Gene Atlas207614_s_atPons33.40060.700Details
BioGPS Gene Atlas207614_s_atPrefrontalCortex65.00060.700Details
BioGPS Gene Atlas207614_s_atProstate41.15060.700Details
BioGPS Gene Atlas207614_s_atSalivarygland23.15060.700Details
BioGPS Gene Atlas207614_s_atSkeletalMuscle27.40060.700Details
BioGPS Gene Atlas207614_s_atSkin23.10060.700Details
BioGPS Gene Atlas207614_s_atSmoothMuscle145.55060.700Details
BioGPS Gene Atlas207614_s_atSpinalcord29.85060.700Details
BioGPS Gene Atlas207614_s_atSubthalamicNucleus27.55060.700Details
BioGPS Gene Atlas207614_s_atSuperiorCervicalGanglion32.35060.700Details
BioGPS Gene Atlas207614_s_atTemporalLobe27.00060.700Details
BioGPS Gene Atlas207614_s_atTestis60.25060.700Details
BioGPS Gene Atlas207614_s_atTestisGermCell314.25060.700Details
BioGPS Gene Atlas207614_s_atTestisIntersitial440.80060.700Details
BioGPS Gene Atlas207614_s_atTestisLeydigCell194.55060.700Details
BioGPS Gene Atlas207614_s_atTestisSeminiferousTubule158.65060.700Details
BioGPS Gene Atlas207614_s_atThalamus34.50060.700Details
BioGPS Gene Atlas207614_s_atThymus25.30060.700Details
BioGPS Gene Atlas207614_s_atThyroid37.80060.700Details
BioGPS Gene Atlas207614_s_atTongue28.45060.700Details
BioGPS Gene Atlas207614_s_atTonsil49.95060.700Details
BioGPS Gene Atlas207614_s_atTrachea26.20060.700Details
BioGPS Gene Atlas207614_s_atTrigeminalGanglion33.15060.700Details
BioGPS Gene Atlas207614_s_atUterus36.45060.700Details
BioGPS Gene Atlas207614_s_atUterusCorpus24.10060.700Details
BioGPS Gene Atlas207614_s_atWholeBlood42.75060.700Details
BioGPS Gene Atlas207614_s_atWholebrain42.90060.700Details
BioGPS Gene Atlas207614_s_atcolon36.50060.700Details
BioGPS Gene Atlas207614_s_atpineal_day115.24060.700Details
BioGPS Gene Atlas207614_s_atpineal_night86.06060.700Details
BioGPS Gene Atlas207614_s_atretina39.10060.700Details
BioGPS Gene Atlas207614_s_atsmall_intestine28.70060.700Details
BioGPS NCI60207614_s_at786511.094398.020Details
BioGPS NCI60207614_s_atA172276.550398.020Details
BioGPS NCI60207614_s_atA204333.038398.020Details
BioGPS NCI60207614_s_atA361412.700398.020Details
BioGPS NCI60207614_s_atA4981169.702398.020Details
BioGPS NCI60207614_s_atA549426.800398.020Details
BioGPS NCI60207614_s_atACC3147.004398.020Details
BioGPS NCI60207614_s_atACHN446.395398.020Details
BioGPS NCI60207614_s_atALVA31536.830398.020Details
BioGPS NCI60207614_s_atCAKI1561.756398.020Details
BioGPS NCI60207614_s_atCCRT CEM142.347398.020Details
BioGPS NCI60207614_s_atCOLO205201.461398.020Details
BioGPS NCI60207614_s_atDLD1364.080398.020Details
BioGPS NCI60207614_s_atDU145327.060398.020Details
BioGPS NCI60207614_s_atEKVX368.953398.020Details
BioGPS NCI60207614_s_atGM133343.245398.020Details
BioGPS NCI60207614_s_atGM1600416.877398.020Details
BioGPS NCI60207614_s_atGM2313521.320398.020Details
BioGPS NCI60207614_s_atGM2345559.331398.020Details
BioGPS NCI60207614_s_atGM2493439.975398.020Details
BioGPS NCI60207614_s_atGM97255.985398.020Details
BioGPS NCI60207614_s_atHCC2998535.657398.020Details
BioGPS NCI60207614_s_atHCT116458.292398.020Details
BioGPS NCI60207614_s_atHCT15400.591398.020Details
BioGPS NCI60207614_s_atHEK 293 T-rex393.716398.020Details
BioGPS NCI60207614_s_atHEK 293T594.660398.020Details
BioGPS NCI60207614_s_atHEK293363.487398.020Details
BioGPS NCI60207614_s_atHELA595.963398.020Details
BioGPS NCI60207614_s_atHEPG2374.182398.020Details
BioGPS NCI60207614_s_atHL60307.193398.020Details
BioGPS NCI60207614_s_atHOP621052.279398.020Details
BioGPS NCI60207614_s_atHOP92303.999398.020Details
BioGPS NCI60207614_s_atHS578T355.323398.020Details
BioGPS NCI60207614_s_atHSG369.082398.020Details
BioGPS NCI60207614_s_atHT1080470.881398.020Details
BioGPS NCI60207614_s_atHT29525.162398.020Details
BioGPS NCI60207614_s_atIGROV1354.897398.020Details
BioGPS NCI60207614_s_atIOSE80361.638398.020Details
BioGPS NCI60207614_s_atJURKAT222.873398.020Details
BioGPS NCI60207614_s_atK562614.472398.020Details
BioGPS NCI60207614_s_atKM12255.817398.020Details
BioGPS NCI60207614_s_atLN18387.039398.020Details
BioGPS NCI60207614_s_atLNCAP299.877398.020Details
BioGPS NCI60207614_s_atLOX IMVI238.736398.020Details
BioGPS NCI60207614_s_atM14838.058398.020Details
BioGPS NCI60207614_s_atMALME 3M438.397398.020Details
BioGPS NCI60207614_s_atMCF7369.034398.020Details
BioGPS NCI60207614_s_atMD MB231378.795398.020Details
BioGPS NCI60207614_s_atMDA MB435204.025398.020Details
BioGPS NCI60207614_s_atMOLT4381.756398.020Details
BioGPS NCI60207614_s_atNCI 460379.895398.020Details
BioGPS NCI60207614_s_atNCI H226379.943398.020Details
BioGPS NCI60207614_s_atNCI H23442.724398.020Details
BioGPS NCI60207614_s_atNCI H322M57.795398.020Details
BioGPS NCI60207614_s_atNCVADR RES366.724398.020Details
BioGPS NCI60207614_s_atOVCAR3263.255398.020Details
BioGPS NCI60207614_s_atOVCAR4538.296398.020Details
BioGPS NCI60207614_s_atOVCAR5185.424398.020Details
BioGPS NCI60207614_s_atOVCAR8359.660398.020Details
BioGPS NCI60207614_s_atPANC1130.441398.020Details
BioGPS NCI60207614_s_atRL7775.927398.020Details
BioGPS NCI60207614_s_atRPMI 8226498.427398.020Details
BioGPS NCI60207614_s_atRS11846716.077398.020Details
BioGPS NCI60207614_s_atRXF393374.703398.020Details
BioGPS NCI60207614_s_atSAOS2310.565398.020Details
BioGPS NCI60207614_s_atSF268386.821398.020Details
BioGPS NCI60207614_s_atSF295426.880398.020Details
BioGPS NCI60207614_s_atSF539457.192398.020Details
BioGPS NCI60207614_s_atSHSYSY+RA383.188398.020Details
BioGPS NCI60207614_s_atSHSYSY-RA370.958398.020Details
BioGPS NCI60207614_s_atSKMEL2381.879398.020Details
BioGPS NCI60207614_s_atSKMEL28261.556398.020Details
BioGPS NCI60207614_s_atSKMEL5524.115398.020Details
BioGPS NCI60207614_s_atSKOV3183.428398.020Details
BioGPS NCI60207614_s_atSN12C281.470398.020Details
BioGPS NCI60207614_s_atSNB19674.241398.020Details
BioGPS NCI60207614_s_atSNB75375.390398.020Details
BioGPS NCI60207614_s_atSR397.901398.020Details
BioGPS NCI60207614_s_atSW620543.996398.020Details
BioGPS NCI60207614_s_atT24201.381398.020Details
BioGPS NCI60207614_s_atT3M4183.389398.020Details
BioGPS NCI60207614_s_atTK10876.880398.020Details
BioGPS NCI60207614_s_atU118401.343398.020Details
BioGPS NCI60207614_s_atU138387.872398.020Details
BioGPS NCI60207614_s_atU20S226.754398.020Details
BioGPS NCI60207614_s_atU251331.829398.020Details
BioGPS NCI60207614_s_atU87476.176398.020Details
BioGPS NCI60207614_s_atUACC257199.223398.020Details
BioGPS NCI60207614_s_atUACC62451.165398.020Details
BioGPS NCI60207614_s_atUO31437.539398.020Details
BioGPS NCI60207614_s_atZR75_187.728398.020Details
BioGPS NCI60207614_s_atastrocytes280.414398.020Details
BioGPS NCI60207614_s_athuh-7215.512398.020Details