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Gene ID: 1075 | CTSC Antibody Resource


CTSC Antibody Resource
Gene Full Name: 
cathepsin C
Uniprot: 
P53634
Protein Name: 
dipeptidyl peptidase 1
Nucleotide: 
NM_001814
Alias: 
JP;HMS;JPD;PLS;CPPI;DPP1;DPPI;PALS;DPP-I;PDON1;
Ensembl: 
ENSG00000109861
Location: 
11q14.2
HPRD: 
03841
NCBI Gene: 
1075
MIM: 
602365

Summary: 
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function: 
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
Subcellular location: 
Lysosome.
PTM: 
Disulfide bond;
Disease: 
Papillon-Lefevre syndrome (PLS) [MIM:245000]: An autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. Note: The disease is caused by mutations affecting the gene represented in this entry. Haim-Munk syndrome (HMS) [MIM:245010]: An autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. Note: The disease is caused by mutations affecting the gene represented in this entry. Periodontititis, aggressive, 1 (AP1) [MIM:170650]: A disease characterized by severe and protracted gingival infections, generalized or localized, leading to tooth loss. Amounts of microbial deposits are generally inconsistent with the severity of periodontal tissue destruction and the progression of attachment and bone loss may be self arresting. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP60116_P050 CTSC antibody - middle region (ARP60116_P050) Polyclonal Bovine, Human, Mouse WB 50ug $289 Details
Polyclonal Antibody ARP60117_P050 CTSC Antibody - N-terminal region (ARP60117_P050) Polyclonal Human, Pig, Rabbit WB 50ug $289 Details
Polyclonal Antibody OAEC01700 Dipeptidyl-peptidase 1 (heavy chain,Cleaved-Arg394) Antibody (OAEC01700) Human WB, ELISA 100ug $229 Details
Polyclonal Antibody OAAF05371 CTSC (heavy chain, Cleaved-Arg394) Antibody (OAAF05371) Polyclonal Human WB, ELISA 100 ug $229 Details

Show all CTSC antibodies


Product Images
CTSC antibody - middle region (ARP60116_P050) in Human PANC1 cells using Western Blot

Sample Type: Human PANC1

CTSC Antibody - N-terminal region (ARP60117_P050) in Human HCT15 cells using Western Blot

Sample Type: Human HCT15

CTSC (heavy chain, Cleaved-Arg394) Antibody (OAAF05371) in Jurkat cells using Western Blot

Sample Type: Jurkat

Dipeptidyl-peptidase 1 (heavy chain,Cleaved-Arg394) Antibody (OAEC01700) in Jurkat cells using Western Blot

Sample Type: Jurkat


CTSC Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60116 African elephant CTSC antibody; Loxodonta africana CTSC antibody G3SMJ4 79.0%
ARP60117 African elephant CTSC antibody; Loxodonta africana CTSC antibody G3SMJ4 79.0%
ARP60116 Bovine CTSC antibody; Bos taurus CTSC antibody Q3ZCJ8 86.0%
ARP60116 Bovine CTSC antibody; Bos taurus CTSC antibody F1N455 86.0%
ARP60116 Cat CTSC antibody; Felis catus CTSC antibody M3W9M0 86.0%
ARP60116 Chimpanzee CTSC antibody; Pan troglodytes CTSC antibody H2Q4I9 100.0%
ARP60117 Chimpanzee CTSC antibody; Pan troglodytes CTSC antibody H2Q4I9 100.0%
ARP60116 Crab-eating macaque CTSC antibody; Macaca fascicularis CTSC antibody Q60HG6 100.0%
ARP60117 Crab-eating macaque CTSC antibody; Macaca fascicularis CTSC antibody Q60HG6 100.0%
ARP60116 Dog CTSC antibody; Canis familiaris CTSC antibody J9NSE7 79.0%
ARP60116 Horse CTSC antibody; Equus caballus CTSC antibody F6TIB2 86.0%
ARP60116 Human CTSC antibody; Homo sapiens CTSC antibody P53634 100.0%
ARP60117 Human CTSC antibody; Homo sapiens CTSC antibody P53634 100.0%
ARP60116 Human CTSC antibody; Homo sapiens CTSC antibody H0YCY8 100.0%
ARP60117 Human CTSC antibody; Homo sapiens CTSC antibody H0YCY8 100.0%
ARP60116 Mouse CTSC antibody; Mus musculus CTSC antibody P97821 79.0%
ARP60116 Mouse CTSC antibody; Mus musculus CTSC antibody Q3U9B7 79.0%
ARP60116 Mouse CTSC antibody; Mus musculus CTSC antibody Q3UAF5 79.0%
ARP60116 Mouse CTSC antibody; Mus musculus CTSC antibody Q3UBY5 79.0%
ARP60116 Mouse CTSC antibody; Mus musculus CTSC antibody Q8BQL3 79.0%
ARP60116 Mouse CTSC antibody; Mus musculus CTSC antibody Q9DCV1 79.0%
ARP60116 Mouse CTSC antibody; Mus musculus CTSC antibody D3Z220 79.0%
ARP60117 Pig CTSC antibody; Sus scrofa CTSC antibody F1STR1 79.0%
ARP60116 Rhesus macaque CTSC antibody; Macaca mulatta CTSC antibody F7H3F1 100.0%
ARP60117 Rhesus macaque CTSC antibody; Macaca mulatta CTSC antibody F7H3F1 100.0%
ARP60116 Rhesus macaque CTSC antibody; Macaca mulatta CTSC antibody H9FNY7 100.0%
ARP60117 Rhesus macaque CTSC antibody; Macaca mulatta CTSC antibody H9FNY7 100.0%
ARP60117 Small-eared galago CTSC antibody; Otolemur garnettii CTSC antibody H0X013 86.0%
ARP60116 Sumatran orangutan CTSC antibody; Pongo abelii CTSC antibody Q5RB02 100.0%
ARP60117 Sumatran orangutan CTSC antibody; Pongo abelii CTSC antibody Q5RB02 100.0%
ARP60116 Sumatran orangutan CTSC antibody; Pongo abelii CTSC antibody H2NEW7 100.0%
ARP60117 Sumatran orangutan CTSC antibody; Pongo abelii CTSC antibody H2NEW7 100.0%
ARP60117 Thirteen-lined ground squirrel CTSC antibody; Spermophilus tridecemlineatus CTSC antibody I3LYH9 91.0%
ARP60117 Thirteen-lined ground squirrel CTSC antibody; Spermophilus tridecemlineatus CTSC antibody I3MYD1 91.0%
ARP60116 White-tufted-ear marmoset CTSC antibody; Callithrix jacchus CTSC antibody U3CIA8 86.0%
ARP60116 White-tufted-ear marmoset CTSC antibody; Callithrix jacchus CTSC antibody F6UY03 86.0%
ARP60117 White-tufted-ear marmoset CTSC antibody; Callithrix jacchus CTSC antibody F6UY03 86.0%
ARP60116 White-tufted-ear marmoset CTSC antibody; Callithrix jacchus CTSC antibody F6UY27 86.0%
ARP60117 White-tufted-ear marmoset CTSC antibody; Callithrix jacchus CTSC antibody F6UY27 86.0%
ARP60116 White-tufted-ear marmoset CTSC antibody; Callithrix jacchus CTSC antibody F7CGB8 86.0%
ARP60117 White-tufted-ear marmoset CTSC antibody; Callithrix jacchus CTSC antibody U3CIA8 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas201487_at721_B_lymphoblasts806.250117.640Details
BioGPS Gene Atlas201487_atAdipocyte64.450117.640Details
BioGPS Gene Atlas201487_atAdrenalCortex21.400117.640Details
BioGPS Gene Atlas201487_atAdrenalgland20.950117.640Details
BioGPS Gene Atlas201487_atAmygdala10.500117.640Details
BioGPS Gene Atlas201487_atAppendix28.850117.640Details
BioGPS Gene Atlas201487_atAtrioventricularNode12.000117.640Details
BioGPS Gene Atlas201487_atBDCA4+_DentriticCells883.700117.640Details
BioGPS Gene Atlas201487_atBonemarrow93.150117.640Details
BioGPS Gene Atlas201487_atBronchialEpithelialCells376.700117.640Details
BioGPS Gene Atlas201487_atCD105+_Endothelial107.900117.640Details
BioGPS Gene Atlas201487_atCD14+_Monocytes615.800117.640Details
BioGPS Gene Atlas201487_atCD19+_BCells(neg._sel.)39.200117.640Details
BioGPS Gene Atlas201487_atCD33+_Myeloid494.400117.640Details
BioGPS Gene Atlas201487_atCD34+281.200117.640Details
BioGPS Gene Atlas201487_atCD4+_Tcells99.700117.640Details
BioGPS Gene Atlas201487_atCD56+_NKCells891.500117.640Details
BioGPS Gene Atlas201487_atCD71+_EarlyErythroid9.150117.640Details
BioGPS Gene Atlas201487_atCD8+_Tcells152.200117.640Details
BioGPS Gene Atlas201487_atCardiacMyocytes162.850117.640Details
BioGPS Gene Atlas201487_atCaudatenucleus10.150117.640Details
BioGPS Gene Atlas201487_atCerebellum5.950117.640Details
BioGPS Gene Atlas201487_atCerebellumPeduncles11.250117.640Details
BioGPS Gene Atlas201487_atCiliaryGanglion26.100117.640Details
BioGPS Gene Atlas201487_atCingulateCortex8.200117.640Details
BioGPS Gene Atlas201487_atColorectaladenocarcinoma9.800117.640Details
BioGPS Gene Atlas201487_atDorsalRootGanglion12.900117.640Details
BioGPS Gene Atlas201487_atFetalThyroid53.550117.640Details
BioGPS Gene Atlas201487_atFetalbrain8.750117.640Details
BioGPS Gene Atlas201487_atFetalliver29.100117.640Details
BioGPS Gene Atlas201487_atFetallung136.950117.640Details
BioGPS Gene Atlas201487_atGlobusPallidus9.800117.640Details
BioGPS Gene Atlas201487_atHeart19.500117.640Details
BioGPS Gene Atlas201487_atHypothalamus14.750117.640Details
BioGPS Gene Atlas201487_atKidney170.500117.640Details
BioGPS Gene Atlas201487_atLeukemia_chronicMyelogenousK-562125.400117.640Details
BioGPS Gene Atlas201487_atLeukemia_promyelocytic-HL-6032.650117.640Details
BioGPS Gene Atlas201487_atLeukemialymphoblastic(MOLT-4)54.900117.640Details
BioGPS Gene Atlas201487_atLiver26.200117.640Details
BioGPS Gene Atlas201487_atLung594.500117.640Details
BioGPS Gene Atlas201487_atLymphnode342.800117.640Details
BioGPS Gene Atlas201487_atLymphoma_burkitts(Daudi)138.700117.640Details
BioGPS Gene Atlas201487_atLymphoma_burkitts(Raji)27.700117.640Details
BioGPS Gene Atlas201487_atMedullaOblongata8.500117.640Details
BioGPS Gene Atlas201487_atOccipitalLobe7.800117.640Details
BioGPS Gene Atlas201487_atOlfactoryBulb25.150117.640Details
BioGPS Gene Atlas201487_atOvary17.100117.640Details
BioGPS Gene Atlas201487_atPancreas45.150117.640Details
BioGPS Gene Atlas201487_atPancreaticIslet73.450117.640Details
BioGPS Gene Atlas201487_atParietalLobe8.250117.640Details
BioGPS Gene Atlas201487_atPituitary37.900117.640Details
BioGPS Gene Atlas201487_atPlacenta269.800117.640Details
BioGPS Gene Atlas201487_atPons8.050117.640Details
BioGPS Gene Atlas201487_atPrefrontalCortex9.600117.640Details
BioGPS Gene Atlas201487_atProstate27.000117.640Details
BioGPS Gene Atlas201487_atSalivarygland162.350117.640Details
BioGPS Gene Atlas201487_atSkeletalMuscle10.850117.640Details
BioGPS Gene Atlas201487_atSkin17.750117.640Details
BioGPS Gene Atlas201487_atSmoothMuscle355.250117.640Details
BioGPS Gene Atlas201487_atSpinalcord20.350117.640Details
BioGPS Gene Atlas201487_atSubthalamicNucleus7.350117.640Details
BioGPS Gene Atlas201487_atSuperiorCervicalGanglion34.300117.640Details
BioGPS Gene Atlas201487_atTemporalLobe9.950117.640Details
BioGPS Gene Atlas201487_atTestis8.350117.640Details
BioGPS Gene Atlas201487_atTestisGermCell41.400117.640Details
BioGPS Gene Atlas201487_atTestisIntersitial11.300117.640Details
BioGPS Gene Atlas201487_atTestisLeydigCell11.900117.640Details
BioGPS Gene Atlas201487_atTestisSeminiferousTubule8.900117.640Details
BioGPS Gene Atlas201487_atThalamus8.100117.640Details
BioGPS Gene Atlas201487_atThymus85.050117.640Details
BioGPS Gene Atlas201487_atThyroid142.400117.640Details
BioGPS Gene Atlas201487_atTongue19.100117.640Details
BioGPS Gene Atlas201487_atTonsil171.150117.640Details
BioGPS Gene Atlas201487_atTrachea172.900117.640Details
BioGPS Gene Atlas201487_atTrigeminalGanglion11.200117.640Details
BioGPS Gene Atlas201487_atUterus25.700117.640Details
BioGPS Gene Atlas201487_atUterusCorpus10.250117.640Details
BioGPS Gene Atlas201487_atWholeBlood555.500117.640Details
BioGPS Gene Atlas201487_atWholebrain12.450117.640Details
BioGPS Gene Atlas201487_atcolon194.900117.640Details
BioGPS Gene Atlas201487_atpineal_day9.800117.640Details
BioGPS Gene Atlas201487_atpineal_night11.480117.640Details
BioGPS Gene Atlas201487_atretina121.675117.640Details
BioGPS Gene Atlas201487_atsmall_intestine367.800117.640Details
BioGPS NCI60201487_at786973.9561297.900Details
BioGPS NCI60201487_atA172144.5661297.900Details
BioGPS NCI60201487_atA2046.7891297.900Details
BioGPS NCI60201487_atA361871.4051297.900Details
BioGPS NCI60201487_atA4981363.8361297.900Details
BioGPS NCI60201487_atA549572.7871297.900Details
BioGPS NCI60201487_atACC3109.5681297.900Details
BioGPS NCI60201487_atACHN2394.7241297.900Details
BioGPS NCI60201487_atALVA311613.6161297.900Details
BioGPS NCI60201487_atCAKI11143.6461297.900Details
BioGPS NCI60201487_atCCRT CEM717.7021297.900Details
BioGPS NCI60201487_atCOLO2052396.5461297.900Details
BioGPS NCI60201487_atDLD1283.7991297.900Details
BioGPS NCI60201487_atDU1451026.9281297.900Details
BioGPS NCI60201487_atEKVX1899.9241297.900Details
BioGPS NCI60201487_atGM133747.0121297.900Details
BioGPS NCI60201487_atGM1600292.6631297.900Details
BioGPS NCI60201487_atGM23131898.2931297.900Details
BioGPS NCI60201487_atGM2345350.0611297.900Details
BioGPS NCI60201487_atGM24931319.0311297.900Details
BioGPS NCI60201487_atGM97492.3591297.900Details
BioGPS NCI60201487_atHCC29981883.3081297.900Details
BioGPS NCI60201487_atHCT116456.1361297.900Details
BioGPS NCI60201487_atHCT15320.7401297.900Details
BioGPS NCI60201487_atHEK 293 T-rex592.6531297.900Details
BioGPS NCI60201487_atHEK 293T222.0021297.900Details
BioGPS NCI60201487_atHEK293511.1151297.900Details
BioGPS NCI60201487_atHELA3251.3041297.900Details
BioGPS NCI60201487_atHEPG22245.3801297.900Details
BioGPS NCI60201487_atHL60378.9761297.900Details
BioGPS NCI60201487_atHOP623179.5671297.900Details
BioGPS NCI60201487_atHOP92841.7041297.900Details
BioGPS NCI60201487_atHS578T1028.1991297.900Details
BioGPS NCI60201487_atHSG1437.7901297.900Details
BioGPS NCI60201487_atHT10806.4601297.900Details
BioGPS NCI60201487_atHT292033.2011297.900Details
BioGPS NCI60201487_atIGROV11555.9251297.900Details
BioGPS NCI60201487_atIOSE801040.6611297.900Details
BioGPS NCI60201487_atJURKAT761.9891297.900Details
BioGPS NCI60201487_atK5622682.2421297.900Details
BioGPS NCI60201487_atKM122579.3681297.900Details
BioGPS NCI60201487_atLN181429.4491297.900Details
BioGPS NCI60201487_atLNCAP16.9571297.900Details
BioGPS NCI60201487_atLOX IMVI1863.0011297.900Details
BioGPS NCI60201487_atM141420.8661297.900Details
BioGPS NCI60201487_atMALME 3M253.8041297.900Details
BioGPS NCI60201487_atMCF7497.0311297.900Details
BioGPS NCI60201487_atMD MB2311359.0851297.900Details
BioGPS NCI60201487_atMDA MB4351555.6721297.900Details
BioGPS NCI60201487_atMOLT4993.7331297.900Details
BioGPS NCI60201487_atNCI 4609979.9761297.900Details
BioGPS NCI60201487_atNCI H226709.8331297.900Details
BioGPS NCI60201487_atNCI H23379.7071297.900Details
BioGPS NCI60201487_atNCI H322M4761.8171297.900Details
BioGPS NCI60201487_atNCVADR RES1773.7111297.900Details
BioGPS NCI60201487_atOVCAR3713.5371297.900Details
BioGPS NCI60201487_atOVCAR41925.6581297.900Details
BioGPS NCI60201487_atOVCAR52259.8211297.900Details
BioGPS NCI60201487_atOVCAR81697.7951297.900Details
BioGPS NCI60201487_atPANC1275.6871297.900Details
BioGPS NCI60201487_atRL7729.3401297.900Details
BioGPS NCI60201487_atRPMI 82261562.2221297.900Details
BioGPS NCI60201487_atRS118462030.7221297.900Details
BioGPS NCI60201487_atRXF393961.8911297.900Details
BioGPS NCI60201487_atSAOS231.2581297.900Details
BioGPS NCI60201487_atSF2685144.1521297.900Details
BioGPS NCI60201487_atSF2951746.0901297.900Details
BioGPS NCI60201487_atSF539605.5101297.900Details
BioGPS NCI60201487_atSHSYSY+RA670.9241297.900Details
BioGPS NCI60201487_atSHSYSY-RA121.0481297.900Details
BioGPS NCI60201487_atSKMEL2864.1541297.900Details
BioGPS NCI60201487_atSKMEL281707.3661297.900Details
BioGPS NCI60201487_atSKMEL51364.8521297.900Details
BioGPS NCI60201487_atSKOV31950.6121297.900Details
BioGPS NCI60201487_atSN12C2254.6511297.900Details
BioGPS NCI60201487_atSNB19877.7991297.900Details
BioGPS NCI60201487_atSNB751191.9351297.900Details
BioGPS NCI60201487_atSR1839.5571297.900Details
BioGPS NCI60201487_atSW6205407.5441297.900Details
BioGPS NCI60201487_atT242943.0531297.900Details
BioGPS NCI60201487_atT3M42516.6021297.900Details
BioGPS NCI60201487_atTK10688.9981297.900Details
BioGPS NCI60201487_atU118177.0621297.900Details
BioGPS NCI60201487_atU13862.6131297.900Details
BioGPS NCI60201487_atU20S1387.2991297.900Details
BioGPS NCI60201487_atU2511737.8271297.900Details
BioGPS NCI60201487_atU87257.5361297.900Details
BioGPS NCI60201487_atUACC2571166.2161297.900Details
BioGPS NCI60201487_atUACC62884.9011297.900Details
BioGPS NCI60201487_atUO312588.4621297.900Details
BioGPS NCI60201487_atZR75_1561.0811297.900Details
BioGPS NCI60201487_atastrocytes712.5961297.900Details
BioGPS NCI60201487_athuh-72255.5101297.900Details