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Gene ID: 200186 | CRTC2 Antibody Resource


CRTC2 Antibody Resource
Gene Full Name: 
CREB regulated transcription coactivator 2
Uniprot: 
Q53ET0
Protein Name: 
CREB-regulated transcription coactivator 2
Nucleotide: 
NM_181715
Alias: 
TORC2;TORC-2;
Ensembl: 
ENSG00000160741
Location: 
1q21.3
HPRD: 
12347
NCBI Gene: 
200186
MIM: 
608972

Summary: 
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
Function: 
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Subcellular location: 
Cytoplasm. Nucleus. Note: Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
PTM: 
Acetylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAEB01028 Goat Anti-CRTC2 / TORC2 (aa 83-96) Antibody (OAEB01028) Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat WB 0.1mg $289 Details
Polyclonal Antibody OAEB01054 CRTC2 Antibody (OAEB01054) Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat WB 0.1mg $289 Details
Polyclonal Antibody ARP36706_P050 CRTC2 Antibody (ARP36706_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP36707_P050 CRTC2 Antibody (ARP36707_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB10466 CRTC2 antibody - C - terminal region (OAAB10466) Human WB 400ul $289 Details
Polyclonal Antibody OAAB10620 CRTC2 antibody - N - terminal region (OAAB10620) Human WB, IHC 400ul $289 Details

Show all CRTC2 antibodies


Product Images
CRTC2 antibody - C - terminal region (OAAB10466) in A2058 cells using Western Blot

Sample Type: A2058

CRTC2 antibody - N - terminal region (OAAB10620) in Human Placenta cells using Immunohistochemistry

Sample Type: Human Placenta

CRTC2 antibody - N - terminal region (OAAB10620) in Jurkat cells using Western Blot

Sample Type: Jurkat

Goat Anti-CRTC2 / TORC2 (aa 83-96) Antibody (OAEB01028) in Jurkat cells using Western Blot

Sample Type: Jurkat

CRTC2 Antibody (OAEB01054) in Jurkat cells using Western Blot

Sample Type: Jurkat


CRTC2 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP36706 African elephant CRTC2 antibody; Loxodonta africana CRTC2 antibody G3TKN0 100.0%
ARP36706 African elephant CRTC2 antibody; Loxodonta africana CRTC2 antibody G3UCN8 100.0%
ARP36706 Bovine CRTC2 antibody; Bos taurus CRTC2 antibody Q08E26 100.0%
ARP36706 Cat CRTC2 antibody; Felis catus CRTC2 antibody M3VWE2 100.0%
ARP36706 Chimpanzee CRTC2 antibody; Pan troglodytes CRTC2 antibody H2Q044 100.0%
ARP36707 Chimpanzee CRTC2 antibody; Pan troglodytes CRTC2 antibody H2Q044 100.0%
ARP36706 Chimpanzee CRTC2 antibody; Pan troglodytes CRTC2 antibody K7CDV6 100.0%
ARP36707 Chimpanzee CRTC2 antibody; Pan troglodytes CRTC2 antibody K7CDV6 100.0%
ARP36706 European domestic ferret CRTC2 antibody; Mustela putorius furo CRTC2 antibody M3Y9D4 100.0%
ARP50668 European domestic ferret CRTC2 antibody; Mustela putorius furo CRTC2 antibody M3Y9D4 85.0%
ARP50668 Giant panda CRTC2 antibody; Ailuropoda melanoleuca CRTC2 antibody G1LZV6 85.0%
ARP36706 Horse CRTC2 antibody; Equus caballus CRTC2 antibody F6VNN8 100.0%
ARP36707 Horse CRTC2 antibody; Equus caballus CRTC2 antibody F6VNN8 91.0%
ARP36707 Human CRTC2 antibody; Homo sapiens CRTC2 antibody H0YDQ8 100.0%
ARP36706 Human CRTC2 antibody; Homo sapiens CRTC2 antibody Q53ET0 100.0%
ARP36707 Human CRTC2 antibody; Homo sapiens CRTC2 antibody Q53ET0 100.0%
ARP36707 Human CRTC2 antibody; Homo sapiens CRTC2 antibody Q5T4K5 100.0%
ARP36706 Mouse CRTC2 antibody; Mus musculus CRTC2 antibody Q3U182 100.0%
ARP36707 Mouse CRTC2 antibody; Mus musculus CRTC2 antibody Q3TDX5 91.0%
ARP36707 Mouse CRTC2 antibody; Mus musculus CRTC2 antibody Q3U182 91.0%
ARP36707 Mouse CRTC2 antibody; Mus musculus CRTC2 antibody Q8R1U3 91.0%
ARP36707 Mouse CRTC2 antibody; Mus musculus CRTC2 antibody Q9D682 91.0%
ARP36706 Northern white-cheeked gibbon CRTC2 antibody; Nomascus leucogenys CRTC2 antibody G1RIK8 100.0%
ARP36707 Northern white-cheeked gibbon CRTC2 antibody; Nomascus leucogenys CRTC2 antibody G1RIK8 91.0%
ARP36706 Pig CRTC2 antibody; Sus scrofa CRTC2 antibody I3L7H8 100.0%
ARP36706 Pig CRTC2 antibody; Sus scrofa CRTC2 antibody F1SFW7 100.0%
ARP36707 Pig CRTC2 antibody; Sus scrofa CRTC2 antibody I3L7H8 91.0%
ARP36707 Pig CRTC2 antibody; Sus scrofa CRTC2 antibody F1SFW7 91.0%
ARP36706 Rabbit CRTC2 antibody; Oryctolagus cuniculus CRTC2 antibody G1TA33 100.0%
ARP36706 Rat CRTC2 antibody; Rattus norvegicus CRTC2 antibody Q3LRZ1 100.0%
ARP36706 Rat CRTC2 antibody; Rattus norvegicus CRTC2 antibody B4F7E3 100.0%
ARP36706 Rat CRTC2 antibody; Rattus norvegicus CRTC2 antibody F1MA21 100.0%
ARP36707 Rat CRTC2 antibody; Rattus norvegicus CRTC2 antibody Q3LRZ1 91.0%
ARP36707 Rat CRTC2 antibody; Rattus norvegicus CRTC2 antibody B4F7E3 91.0%
ARP36707 Rat CRTC2 antibody; Rattus norvegicus CRTC2 antibody F1MA21 91.0%
ARP36706 Rhesus macaque CRTC2 antibody; Macaca mulatta CRTC2 antibody F7AMV1 100.0%
ARP36707 Rhesus macaque CRTC2 antibody; Macaca mulatta CRTC2 antibody F6VJE1 91.0%
ARP36707 Rhesus macaque CRTC2 antibody; Macaca mulatta CRTC2 antibody F6VJF1 91.0%
ARP36707 Rhesus macaque CRTC2 antibody; Macaca mulatta CRTC2 antibody F7AMU1 91.0%
ARP36707 Rhesus macaque CRTC2 antibody; Macaca mulatta CRTC2 antibody F7AMV1 91.0%
ARP36706 Small-eared galago CRTC2 antibody; Otolemur garnettii CRTC2 antibody H0XZ51 100.0%
ARP36706 Small-eared galago CRTC2 antibody; Otolemur garnettii CRTC2 antibody H0XQT9 100.0%
ARP36707 Small-eared galago CRTC2 antibody; Otolemur garnettii CRTC2 antibody H0XZ51 92.0%
ARP36707 Small-eared galago CRTC2 antibody; Otolemur garnettii CRTC2 antibody H0XQT9 92.0%
ARP36706 Sumatran orangutan CRTC2 antibody; Pongo abelii CRTC2 antibody H2N5M8 100.0%
ARP36706 Sumatran orangutan CRTC2 antibody; Pongo abelii CRTC2 antibody K7ETS9 100.0%
ARP36707 Sumatran orangutan CRTC2 antibody; Pongo abelii CRTC2 antibody H2N5M8 91.0%
ARP36707 Sumatran orangutan CRTC2 antibody; Pongo abelii CRTC2 antibody K7ETS9 91.0%
ARP36706 Thirteen-lined ground squirrel CRTC2 antibody; Spermophilus tridecemlineatus CRTC2 antibody I3NFP8 100.0%
ARP36707 Thirteen-lined ground squirrel CRTC2 antibody; Spermophilus tridecemlineatus CRTC2 antibody I3NFP8 91.0%
ARP50668 Three-spined stickleback CRTC2 antibody; Gasterosteus aculeatus CRTC2 antibody G3NEU8 90.0%
ARP36706 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3CDV5 100.0%
ARP36706 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3F4R7 100.0%
ARP36706 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3FGE9 100.0%
ARP36706 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3FKN9 100.0%
ARP36706 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3FV64 100.0%
ARP36706 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody F7G884 100.0%
ARP36706 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody F7GJA8 100.0%
ARP36707 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3CDV5 91.0%
ARP36707 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3F4R7 91.0%
ARP36707 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3FGE9 91.0%
ARP36707 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3FKN9 91.0%
ARP36707 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody U3FV64 91.0%
ARP36707 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody F7G884 91.0%
ARP36707 White-tufted-ear marmoset CRTC2 antibody; Callithrix jacchus CRTC2 antibody F7GJA8 91.0%

Tissue & Cell Line Gene Expression Data