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Gene ID: 51692 | CPSF3 Antibody Resource


CPSF3 Antibody Resource
Gene Full Name: 
cleavage and polyadenylation specific factor 3, 73kDa
Uniprot: 
Q9UKF6
Protein Name: 
cleavage and polyadenylation specificity factor subunit 3
Nucleotide: 
NM_016207
Alias: 
CPSF73;CPSF-73;
Ensembl: 
ENSG00000119203
Location: 
2p25.1
HPRD: 
05825
NCBI Gene: 
51692
MIM: 
606029

Summary: 
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]
Function: 
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.
Subcellular location: 
Nucleus .
PTM: 
Acetylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP40841_T100 CPSF3 antibody - C-terminal region (ARP40841_T100) Polyclonal Bovine, Dog, Human, Mouse, Rabbit, Rat IHC, WB 100ug $229 Details
Polyclonal Antibody ARP40840_T100 CPSF3 antibody - N-terminal region (ARP40840_T100) Polyclonal Bovine, Dog, Human, Mouse, Rabbit, Rat, Zebrafish WB 100ug $229 Details
Polyclonal Antibody OAAB11134 CPSF3 antibody - center region (OAAB11134) Human WB 400ul $289 Details

Show all CPSF3 antibodies


Product Images
CPSF3 antibody - N-terminal region (ARP40840_T100) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

CPSF3 antibody - C-terminal region (ARP40841_T100) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

CPSF3 antibody - C-terminal region (ARP40841_T100) in Human Liver cells using Immunohistochemistry

Sample Type: Human Liver

CPSF3 antibody - center region (OAAB11134) in A375 cells using Western Blot

Sample Type: A375


CPSF3 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP40840 Testudo hermanni CPSF3 antibody K4H924 100.0%
ARP40840 Dibamus sp. JJF-2012 CPSF3 antibody K4H9K3 100.0%
ARP40840 Draco beccarii CPSF3 antibody K4HFF3 100.0%
ARP40840 African clawed frog CPSF3 antibody; Xenopus laevis CPSF3 antibody Q5XGZ1 100.0%
ARP40840 Atlantic salmon CPSF3 antibody; Salmo salar CPSF3 antibody B5X1A0 100.0%
ARP40840 Bovine CPSF3 antibody; Bos taurus CPSF3 antibody P79101 100.0%
ARP40841 Bovine CPSF3 antibody; Bos taurus CPSF3 antibody P79101 93.0%
ARP40840 Cat CPSF3 antibody; Felis catus CPSF3 antibody M3W8I0 100.0%
ARP40841 Cat CPSF3 antibody; Felis catus CPSF3 antibody M3W8I0 93.0%
ARP40840 Chicken CPSF3 antibody; Gallus gallus CPSF3 antibody F1NKW5 100.0%
ARP40840 Chimpanzee CPSF3 antibody; Pan troglodytes CPSF3 antibody G2HFH0 100.0%
ARP40841 Chimpanzee CPSF3 antibody; Pan troglodytes CPSF3 antibody G2HFH0 100.0%
ARP40840 Chinese softshell turtle CPSF3 antibody; Pelodiscus sinensis CPSF3 antibody K7GD69 100.0%
ARP40841 Chinese softshell turtle CPSF3 antibody; Pelodiscus sinensis CPSF3 antibody K7GD69 79.0%
ARP40840 Collared flycatcher CPSF3 antibody; Ficedula albicollis CPSF3 antibody U3JVQ1 100.0%
ARP40841 Collared flycatcher CPSF3 antibody; Ficedula albicollis CPSF3 antibody U3JVQ1 79.0%
ARP40840 Diamondback terrapin CPSF3 antibody; Malaclemys terrapin CPSF3 antibody K4HDC3 100.0%
ARP40840 Dog CPSF3 antibody; Canis familiaris CPSF3 antibody E2R7R2 100.0%
ARP40841 Dog CPSF3 antibody; Canis familiaris CPSF3 antibody E2R7R2 93.0%
ARP40840 Domestic duck CPSF3 antibody; Anas platyrhynchos CPSF3 antibody U3IH88 100.0%
ARP40841 Domestic duck CPSF3 antibody; Anas platyrhynchos CPSF3 antibody U3IH88 79.0%
ARP40840 Duckbill platypus CPSF3 antibody; Ornithorhynchus anatinus CPSF3 antibody F6PHY6 100.0%
ARP40841 Duckbill platypus CPSF3 antibody; Ornithorhynchus anatinus CPSF3 antibody F6PHY6 86.0%
ARP40840 European domestic ferret CPSF3 antibody; Mustela putorius furo CPSF3 antibody M3YP58 100.0%
ARP40841 European domestic ferret CPSF3 antibody; Mustela putorius furo CPSF3 antibody M3YP58 93.0%
ARP40840 Giant panda CPSF3 antibody; Ailuropoda melanoleuca CPSF3 antibody G1LPK4 100.0%
ARP40841 Giant panda CPSF3 antibody; Ailuropoda melanoleuca CPSF3 antibody G1LPK4 93.0%
ARP40840 Gray short-tailed opossum CPSF3 antibody; Monodelphis domestica CPSF3 antibody F7D3K9 100.0%
ARP40841 Gray short-tailed opossum CPSF3 antibody; Monodelphis domestica CPSF3 antibody F7D3K9 79.0%
ARP40840 Green anole CPSF3 antibody; Anolis carolinensis CPSF3 antibody G1KA18 100.0%
ARP40841 Green anole CPSF3 antibody; Anolis carolinensis CPSF3 antibody G1KA18 86.0%
ARP40840 Horse CPSF3 antibody; Equus caballus CPSF3 antibody F7CPI2 100.0%
ARP40841 Horse CPSF3 antibody; Equus caballus CPSF3 antibody L7MSX5 93.0%
ARP40841 Horse CPSF3 antibody; Equus caballus CPSF3 antibody F7CPI2 93.0%
ARP40840 Human CPSF3 antibody; Homo sapiens CPSF3 antibody Q9UKF6 100.0%
ARP40841 Human CPSF3 antibody; Homo sapiens CPSF3 antibody Q9UKF6 100.0%
ARP40840 Human CPSF3 antibody; Homo sapiens CPSF3 antibody Q05BZ5 100.0%
ARP40840 Human CPSF3 antibody; Homo sapiens CPSF3 antibody G5E9W3 100.0%
ARP40841 Human CPSF3 antibody; Homo sapiens CPSF3 antibody G5E9W3 100.0%
ARP40840 Hydra CPSF3 antibody; Hydra vulgaris CPSF3 antibody T2M417 86.0%
ARP40840 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q9QXK7 100.0%
ARP40840 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q3TC91 100.0%
ARP40840 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q3U057 100.0%
ARP40840 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q497G2 100.0%
ARP40841 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q8BRA5 93.0%
ARP40841 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q9CT87 93.0%
ARP40841 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q9CWL0 93.0%
ARP40841 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q9QXK7 93.0%
ARP40841 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q3TC91 93.0%
ARP40841 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q3U057 93.0%
ARP40840 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q3UDS1 93.0%
ARP40841 Mouse CPSF3 antibody; Mus musculus CPSF3 antibody Q3UDS1 93.0%
ARP40840 Northern white-cheeked gibbon CPSF3 antibody; Nomascus leucogenys CPSF3 antibody G1RSN3 100.0%
ARP40841 Northern white-cheeked gibbon CPSF3 antibody; Nomascus leucogenys CPSF3 antibody G1RSN3 100.0%
ARP40840 Pig CPSF3 antibody; Sus scrofa CPSF3 antibody I3LKR1 100.0%
ARP40841 Pig CPSF3 antibody; Sus scrofa CPSF3 antibody I3LKR1 93.0%
ARP40840 Rabbit CPSF3 antibody; Oryctolagus cuniculus CPSF3 antibody G1SKA3 100.0%
ARP40841 Rabbit CPSF3 antibody; Oryctolagus cuniculus CPSF3 antibody G1SKA3 86.0%
ARP40840 Rat CPSF3 antibody; Rattus norvegicus CPSF3 antibody Q499P4 100.0%
ARP40840 Rat CPSF3 antibody; Rattus norvegicus CPSF3 antibody G3V6W7 100.0%
ARP40841 Rat CPSF3 antibody; Rattus norvegicus CPSF3 antibody Q499P4 93.0%
ARP40841 Rat CPSF3 antibody; Rattus norvegicus CPSF3 antibody G3V6W7 93.0%
ARP40840 Rhesus macaque CPSF3 antibody; Macaca mulatta CPSF3 antibody H9FVQ3 100.0%
ARP40841 Rhesus macaque CPSF3 antibody; Macaca mulatta CPSF3 antibody H9FVQ3 100.0%
ARP40841 Rhesus macaque CPSF3 antibody; Macaca mulatta CPSF3 antibody F7EVB1 100.0%
ARP40840 Small-eared galago CPSF3 antibody; Otolemur garnettii CPSF3 antibody H0WJ50 100.0%
ARP40841 Small-eared galago CPSF3 antibody; Otolemur garnettii CPSF3 antibody H0WJ50 93.0%
ARP40840 Sumatran orangutan CPSF3 antibody; Pongo abelii CPSF3 antibody H2P703 100.0%
ARP40841 Sumatran orangutan CPSF3 antibody; Pongo abelii CPSF3 antibody H2P703 100.0%
ARP40840 Tasmanian devil CPSF3 antibody; Sarcophilus harrisii CPSF3 antibody G3VY42 100.0%
ARP40841 Tasmanian devil CPSF3 antibody; Sarcophilus harrisii CPSF3 antibody G3VY42 86.0%
ARP40840 Thirteen-lined ground squirrel CPSF3 antibody; Spermophilus tridecemlineatus CPSF3 antibody I3M4C1 100.0%
ARP40841 Thirteen-lined ground squirrel CPSF3 antibody; Spermophilus tridecemlineatus CPSF3 antibody I3M4C1 86.0%
ARP40840 Transparent sea squirt CPSF3 antibody; Ciona intestinalis CPSF3 antibody F6W785 93.0%
ARP40840 Western clawed frog CPSF3 antibody; Xenopus tropicalis CPSF3 antibody Q6DIH6 100.0%
ARP40840 Western clawed frog CPSF3 antibody; Xenopus tropicalis CPSF3 antibody Q28FT5 100.0%
ARP40840 Western clawed frog CPSF3 antibody; Xenopus tropicalis CPSF3 antibody F7E4T0 100.0%
ARP40840 White-throated sparrow CPSF3 antibody; Zonotrichia albicollis CPSF3 antibody D8KWB8 100.0%
ARP40841 White-throated sparrow CPSF3 antibody; Zonotrichia albicollis CPSF3 antibody D8KWB8 79.0%
ARP40840 White-tufted-ear marmoset CPSF3 antibody; Callithrix jacchus CPSF3 antibody F7GM73 100.0%
ARP40841 White-tufted-ear marmoset CPSF3 antibody; Callithrix jacchus CPSF3 antibody F7GM73 100.0%
ARP40841 White-tufted-ear marmoset CPSF3 antibody; Callithrix jacchus CPSF3 antibody F7HIE0 100.0%
ARP40840 Zebra finch CPSF3 antibody; Taeniopygia guttata CPSF3 antibody H0ZS16 100.0%
ARP40841 Zebra finch CPSF3 antibody; Taeniopygia guttata CPSF3 antibody H0ZS16 79.0%
ARP40840 Zebrafish CPSF3 antibody; Danio rerio CPSF3 antibody Q5U3T4 100.0%
ARP40840 Zebrafish CPSF3 antibody; Danio rerio CPSF3 antibody Q6DRG6 100.0%

Tissue & Cell Line Gene Expression Data