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Gene ID: 10987 | COPS5 Antibody Resource


COPS5 Antibody Resource
Gene Full Name: 
COP9 signalosome subunit 5
Uniprot: 
Q92905
Protein Name: 
COP9 signalosome complex subunit 5
Nucleotide: 
NM_006837
Alias: 
CSN5;JAB1;SGN5;MOV-34;
Ensembl: 
ENSG00000121022
Location: 
8q13.1
HPRD: 
06888
NCBI Gene: 
10987
MIM: 
604850

Summary: 
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
Function: 
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
Subcellular location: 
Cytoplasm. Nucleus. Cytoplasm › perinuclear region. Note: Nuclear localization is diminished in the presence of IFIT3.
PTM: 
Acetylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP32834_P050 COPS5 antibody - N-terminal region (ARP32834_P050) Polyclonal Human IHC, WB 50ug $289 Details
Polyclonal Antibody ARP31512_P050 COPS5 antibody - N-terminal region (ARP31512_P050) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rat WB 50ug $289 Details
Polyclonal Antibody OAAB05506 COPS5 antibody - C-terminal region (OAAB05506) Human WB, FC, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAAF02591 COPS5 Antibody (OAAF02591) Polyclonal Human, Mouse WB, ELISA 100 ug $289 Details

Show all COPS5 antibodies


Product Images
COPS5 antibody - N-terminal region (ARP31512_P050) in Human Muscle cells using Western Blot

Sample Type: Human Muscle

COPS5 antibody - N-terminal region (ARP31512_P050) in Mouse B8, Human HEK293 cells using Western Blot

Sample Type: Mouse B8, Human HEK293

COPS5 antibody - N-terminal region (ARP32834_P050) in Human Heart cells using Immunohistochemistry

Sample Type: Human Heart

COPS5 antibody - N-terminal region (ARP32834_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

COPS5 Antibody (OAAF02591) in 293, K562 cells using Western Blot

Sample Type: 293, K562


COPS5 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP31512 African clawed frog COPS5 antibody; Xenopus laevis COPS5 antibody Q6GLM9 93.0%
ARP31512 African elephant COPS5 antibody; Loxodonta africana COPS5 antibody G3TF24 100.0%
ARP31512 Atlantic salmon COPS5 antibody; Salmo salar COPS5 antibody B5DFV3 93.0%
ARP31512 Bovine COPS5 antibody; Bos taurus COPS5 antibody F1MBP8 93.0%
ARP31512 Cat COPS5 antibody; Felis catus COPS5 antibody M3W0S8 100.0%
ARP31512 Chicken COPS5 antibody; Gallus gallus COPS5 antibody Q5ZLC3 93.0%
ARP31512 Chimpanzee COPS5 antibody; Pan troglodytes COPS5 antibody H2R2B4 100.0%
ARP31512 Chinese softshell turtle COPS5 antibody; Pelodiscus sinensis COPS5 antibody K7G7B6 93.0%
ARP31512 Dog COPS5 antibody; Canis familiaris COPS5 antibody E2QWE0 100.0%
ARP31512 Duckbill platypus COPS5 antibody; Ornithorhynchus anatinus COPS5 antibody F6ZS46 100.0%
ARP31512 European domestic ferret COPS5 antibody; Mustela putorius furo COPS5 antibody M3YFJ1 100.0%
ARP31512 European seabass COPS5 antibody; Dicentrarchus labrax COPS5 antibody E6ZIP7 93.0%
ARP31512 Giant panda COPS5 antibody; Ailuropoda melanoleuca COPS5 antibody G1M1K8 100.0%
ARP31512 Gray short-tailed opossum COPS5 antibody; Monodelphis domestica COPS5 antibody F7ETC5 100.0%
ARP31512 Horse COPS5 antibody; Equus caballus COPS5 antibody F7AU83 100.0%
ARP31512 Human COPS5 antibody; Homo sapiens COPS5 antibody E5RFS1 100.0%
ARP31512 Human COPS5 antibody; Homo sapiens COPS5 antibody E5RG35 100.0%
ARP31512 Human COPS5 antibody; Homo sapiens COPS5 antibody E5RK55 100.0%
ARP31512 Human COPS5 antibody; Homo sapiens COPS5 antibody Q92905 100.0%
ARP31512 Mouse COPS5 antibody; Mus musculus COPS5 antibody O35864 100.0%
ARP31512 Mouse COPS5 antibody; Mus musculus COPS5 antibody Q3V0K7 100.0%
ARP31512 Northern white-cheeked gibbon COPS5 antibody; Nomascus leucogenys COPS5 antibody G1RJ82 100.0%
ARP31512 Pig COPS5 antibody; Sus scrofa COPS5 antibody A7TX80 100.0%
ARP31512 Pig COPS5 antibody; Sus scrofa COPS5 antibody F2Z540 100.0%
ARP31512 Rabbit COPS5 antibody; Oryctolagus cuniculus COPS5 antibody G1T1D9 100.0%
ARP31512 Rat COPS5 antibody; Rattus norvegicus COPS5 antibody Q4KM69 100.0%
ARP31512 Rhesus macaque COPS5 antibody; Macaca mulatta COPS5 antibody F7H142 100.0%
ARP31512 Small-eared galago COPS5 antibody; Otolemur garnettii COPS5 antibody H0X6S5 100.0%
ARP31512 Spotted green pufferfish COPS5 antibody; Tetraodon nigroviridis COPS5 antibody H3CXM1 93.0%
ARP31512 Sumatran orangutan COPS5 antibody; Pongo abelii COPS5 antibody H2PQH9 100.0%
ARP31512 Tasmanian devil COPS5 antibody; Sarcophilus harrisii COPS5 antibody G3VVY7 100.0%
ARP31512 Thirteen-lined ground squirrel COPS5 antibody; Spermophilus tridecemlineatus COPS5 antibody I3M9F6 100.0%
ARP31512 West Indian ocean coelacanth COPS5 antibody; Latimeria chalumnae COPS5 antibody H2ZZG1 93.0%
ARP31512 Western clawed frog COPS5 antibody; Xenopus tropicalis COPS5 antibody Q6P635 93.0%
ARP31512 Western clawed frog COPS5 antibody; Xenopus tropicalis COPS5 antibody G8JLU5 93.0%
ARP31512 White-tufted-ear marmoset COPS5 antibody; Callithrix jacchus COPS5 antibody F7IAR2 100.0%
ARP31512 Zebrafish COPS5 antibody; Danio rerio COPS5 antibody Q6PC30 93.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas201652_at721_B_lymphoblasts339.350161.630Details
BioGPS Gene Atlas201652_atAdipocyte123.050161.630Details
BioGPS Gene Atlas201652_atAdrenalCortex79.550161.630Details
BioGPS Gene Atlas201652_atAdrenalgland45.450161.630Details
BioGPS Gene Atlas201652_atAmygdala192.950161.630Details
BioGPS Gene Atlas201652_atAppendix80.700161.630Details
BioGPS Gene Atlas201652_atAtrioventricularNode32.350161.630Details
BioGPS Gene Atlas201652_atBDCA4+_DentriticCells301.400161.630Details
BioGPS Gene Atlas201652_atBonemarrow59.250161.630Details
BioGPS Gene Atlas201652_atBronchialEpithelialCells296.450161.630Details
BioGPS Gene Atlas201652_atCD105+_Endothelial407.250161.630Details
BioGPS Gene Atlas201652_atCD14+_Monocytes366.650161.630Details
BioGPS Gene Atlas201652_atCD19+_BCells(neg._sel.)397.350161.630Details
BioGPS Gene Atlas201652_atCD33+_Myeloid367.250161.630Details
BioGPS Gene Atlas201652_atCD34+532.650161.630Details
BioGPS Gene Atlas201652_atCD4+_Tcells248.550161.630Details
BioGPS Gene Atlas201652_atCD56+_NKCells446.950161.630Details
BioGPS Gene Atlas201652_atCD71+_EarlyErythroid269.950161.630Details
BioGPS Gene Atlas201652_atCD8+_Tcells250.650161.630Details
BioGPS Gene Atlas201652_atCardiacMyocytes162.850161.630Details
BioGPS Gene Atlas201652_atCaudatenucleus138.050161.630Details
BioGPS Gene Atlas201652_atCerebellum50.450161.630Details
BioGPS Gene Atlas201652_atCerebellumPeduncles71.200161.630Details
BioGPS Gene Atlas201652_atCiliaryGanglion46.700161.630Details
BioGPS Gene Atlas201652_atCingulateCortex141.150161.630Details
BioGPS Gene Atlas201652_atColorectaladenocarcinoma117.300161.630Details
BioGPS Gene Atlas201652_atDorsalRootGanglion68.550161.630Details
BioGPS Gene Atlas201652_atFetalThyroid108.050161.630Details
BioGPS Gene Atlas201652_atFetalbrain115.000161.630Details
BioGPS Gene Atlas201652_atFetalliver140.300161.630Details
BioGPS Gene Atlas201652_atFetallung110.950161.630Details
BioGPS Gene Atlas201652_atGlobusPallidus90.600161.630Details
BioGPS Gene Atlas201652_atHeart39.500161.630Details
BioGPS Gene Atlas201652_atHypothalamus326.600161.630Details
BioGPS Gene Atlas201652_atKidney44.700161.630Details
BioGPS Gene Atlas201652_atLeukemia_chronicMyelogenousK-562234.400161.630Details
BioGPS Gene Atlas201652_atLeukemia_promyelocytic-HL-60209.250161.630Details
BioGPS Gene Atlas201652_atLeukemialymphoblastic(MOLT-4)236.400161.630Details
BioGPS Gene Atlas201652_atLiver25.150161.630Details
BioGPS Gene Atlas201652_atLung51.650161.630Details
BioGPS Gene Atlas201652_atLymphnode78.550161.630Details
BioGPS Gene Atlas201652_atLymphoma_burkitts(Daudi)257.000161.630Details
BioGPS Gene Atlas201652_atLymphoma_burkitts(Raji)221.900161.630Details
BioGPS Gene Atlas201652_atMedullaOblongata113.050161.630Details
BioGPS Gene Atlas201652_atOccipitalLobe165.400161.630Details
BioGPS Gene Atlas201652_atOlfactoryBulb85.500161.630Details
BioGPS Gene Atlas201652_atOvary44.900161.630Details
BioGPS Gene Atlas201652_atPancreas101.350161.630Details
BioGPS Gene Atlas201652_atPancreaticIslet133.600161.630Details
BioGPS Gene Atlas201652_atParietalLobe124.200161.630Details
BioGPS Gene Atlas201652_atPituitary146.800161.630Details
BioGPS Gene Atlas201652_atPlacenta124.200161.630Details
BioGPS Gene Atlas201652_atPons98.650161.630Details
BioGPS Gene Atlas201652_atPrefrontalCortex176.850161.630Details
BioGPS Gene Atlas201652_atProstate126.750161.630Details
BioGPS Gene Atlas201652_atSalivarygland97.350161.630Details
BioGPS Gene Atlas201652_atSkeletalMuscle56.000161.630Details
BioGPS Gene Atlas201652_atSkin41.200161.630Details
BioGPS Gene Atlas201652_atSmoothMuscle211.950161.630Details
BioGPS Gene Atlas201652_atSpinalcord210.550161.630Details
BioGPS Gene Atlas201652_atSubthalamicNucleus102.350161.630Details
BioGPS Gene Atlas201652_atSuperiorCervicalGanglion41.800161.630Details
BioGPS Gene Atlas201652_atTemporalLobe92.250161.630Details
BioGPS Gene Atlas201652_atTestis98.050161.630Details
BioGPS Gene Atlas201652_atTestisGermCell264.750161.630Details
BioGPS Gene Atlas201652_atTestisIntersitial389.900161.630Details
BioGPS Gene Atlas201652_atTestisLeydigCell195.600161.630Details
BioGPS Gene Atlas201652_atTestisSeminiferousTubule148.450161.630Details
BioGPS Gene Atlas201652_atThalamus237.350161.630Details
BioGPS Gene Atlas201652_atThymus79.850161.630Details
BioGPS Gene Atlas201652_atThyroid149.650161.630Details
BioGPS Gene Atlas201652_atTongue106.150161.630Details
BioGPS Gene Atlas201652_atTonsil108.600161.630Details
BioGPS Gene Atlas201652_atTrachea58.500161.630Details
BioGPS Gene Atlas201652_atTrigeminalGanglion80.500161.630Details
BioGPS Gene Atlas201652_atUterus98.950161.630Details
BioGPS Gene Atlas201652_atUterusCorpus69.100161.630Details
BioGPS Gene Atlas201652_atWholeBlood267.600161.630Details
BioGPS Gene Atlas201652_atWholebrain123.850161.630Details
BioGPS Gene Atlas201652_atcolon121.800161.630Details
BioGPS Gene Atlas201652_atpineal_day192.820161.630Details
BioGPS Gene Atlas201652_atpineal_night199.980161.630Details
BioGPS Gene Atlas201652_atretina155.100161.630Details
BioGPS Gene Atlas201652_atsmall_intestine113.700161.630Details
BioGPS NCI60201652_at7863468.0772076.670Details
BioGPS NCI60201652_atA1721134.8112076.670Details
BioGPS NCI60201652_atA2041697.1362076.670Details
BioGPS NCI60201652_atA3611904.5332076.670Details
BioGPS NCI60201652_atA4984496.1862076.670Details
BioGPS NCI60201652_atA5492191.9212076.670Details
BioGPS NCI60201652_atACC31062.3342076.670Details
BioGPS NCI60201652_atACHN1130.8592076.670Details
BioGPS NCI60201652_atALVA312258.6792076.670Details
BioGPS NCI60201652_atCAKI12730.0662076.670Details
BioGPS NCI60201652_atCCRT CEM648.3672076.670Details
BioGPS NCI60201652_atCOLO2052628.3542076.670Details
BioGPS NCI60201652_atDLD11996.0492076.670Details
BioGPS NCI60201652_atDU1452967.9512076.670Details
BioGPS NCI60201652_atEKVX1520.6392076.670Details
BioGPS NCI60201652_atGM1332137.2072076.670Details
BioGPS NCI60201652_atGM16001374.9872076.670Details
BioGPS NCI60201652_atGM23131912.0342076.670Details
BioGPS NCI60201652_atGM23451957.5902076.670Details
BioGPS NCI60201652_atGM24932008.8722076.670Details
BioGPS NCI60201652_atGM971325.6452076.670Details
BioGPS NCI60201652_atHCC29982292.0752076.670Details
BioGPS NCI60201652_atHCT1164426.4732076.670Details
BioGPS NCI60201652_atHCT153201.1102076.670Details
BioGPS NCI60201652_atHEK 293 T-rex982.7162076.670Details
BioGPS NCI60201652_atHEK 293T1996.4162076.670Details
BioGPS NCI60201652_atHEK2931172.4592076.670Details
BioGPS NCI60201652_atHELA2409.9282076.670Details
BioGPS NCI60201652_atHEPG21491.7452076.670Details
BioGPS NCI60201652_atHL60898.5662076.670Details
BioGPS NCI60201652_atHOP622378.9062076.670Details
BioGPS NCI60201652_atHOP922482.2562076.670Details
BioGPS NCI60201652_atHS578T3248.8302076.670Details
BioGPS NCI60201652_atHSG2000.0892076.670Details
BioGPS NCI60201652_atHT10802916.5372076.670Details
BioGPS NCI60201652_atHT292690.6012076.670Details
BioGPS NCI60201652_atIGROV12556.1322076.670Details
BioGPS NCI60201652_atIOSE801602.3882076.670Details
BioGPS NCI60201652_atJURKAT2818.2202076.670Details
BioGPS NCI60201652_atK5622698.8502076.670Details
BioGPS NCI60201652_atKM122387.6702076.670Details
BioGPS NCI60201652_atLN181752.9822076.670Details
BioGPS NCI60201652_atLNCAP1883.2742076.670Details
BioGPS NCI60201652_atLOX IMVI2268.6062076.670Details
BioGPS NCI60201652_atM14956.5302076.670Details
BioGPS NCI60201652_atMALME 3M704.0132076.670Details
BioGPS NCI60201652_atMCF71927.3002076.670Details
BioGPS NCI60201652_atMD MB2311872.0702076.670Details
BioGPS NCI60201652_atMDA MB4352184.1742076.670Details
BioGPS NCI60201652_atMOLT43074.9712076.670Details
BioGPS NCI60201652_atNCI 4601243.6252076.670Details
BioGPS NCI60201652_atNCI H2261338.2752076.670Details
BioGPS NCI60201652_atNCI H231982.1452076.670Details
BioGPS NCI60201652_atNCI H322M1732.9672076.670Details
BioGPS NCI60201652_atNCVADR RES3552.5542076.670Details
BioGPS NCI60201652_atOVCAR31991.1742076.670Details
BioGPS NCI60201652_atOVCAR44456.0162076.670Details
BioGPS NCI60201652_atOVCAR53386.9872076.670Details
BioGPS NCI60201652_atOVCAR82817.8882076.670Details
BioGPS NCI60201652_atPANC12275.3452076.670Details
BioGPS NCI60201652_atRL72688.6142076.670Details
BioGPS NCI60201652_atRPMI 8226888.3552076.670Details
BioGPS NCI60201652_atRS118461946.6902076.670Details
BioGPS NCI60201652_atRXF3931929.2512076.670Details
BioGPS NCI60201652_atSAOS21250.5582076.670Details
BioGPS NCI60201652_atSF2681266.0652076.670Details
BioGPS NCI60201652_atSF2952137.9602076.670Details
BioGPS NCI60201652_atSF5393488.1032076.670Details
BioGPS NCI60201652_atSHSYSY+RA1458.6362076.670Details
BioGPS NCI60201652_atSHSYSY-RA963.2982076.670Details
BioGPS NCI60201652_atSKMEL21670.8702076.670Details
BioGPS NCI60201652_atSKMEL28926.5042076.670Details
BioGPS NCI60201652_atSKMEL52001.8802076.670Details
BioGPS NCI60201652_atSKOV33756.6942076.670Details
BioGPS NCI60201652_atSN12C1399.6422076.670Details
BioGPS NCI60201652_atSNB191040.6132076.670Details
BioGPS NCI60201652_atSNB751552.6882076.670Details
BioGPS NCI60201652_atSR1867.2292076.670Details
BioGPS NCI60201652_atSW6202913.7142076.670Details
BioGPS NCI60201652_atT242728.2972076.670Details
BioGPS NCI60201652_atT3M42126.4182076.670Details
BioGPS NCI60201652_atTK102276.1012076.670Details
BioGPS NCI60201652_atU1182044.0322076.670Details
BioGPS NCI60201652_atU1381746.7832076.670Details
BioGPS NCI60201652_atU20S1801.4322076.670Details
BioGPS NCI60201652_atU2511319.0392076.670Details
BioGPS NCI60201652_atU872803.9872076.670Details
BioGPS NCI60201652_atUACC2571564.7972076.670Details
BioGPS NCI60201652_atUACC621783.6382076.670Details
BioGPS NCI60201652_atUO312074.7772076.670Details
BioGPS NCI60201652_atZR75_14915.8492076.670Details
BioGPS NCI60201652_atastrocytes1478.3032076.670Details
BioGPS NCI60201652_athuh-72152.6172076.670Details