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Gene ID: 51138 | Cops4 Antibody Resource


Cops4 Antibody Resource
Gene Full Name: 
COP9 signalosome subunit 4
Uniprot: 
Q9BT78
Protein Name: 
COP9 signalosome complex subunit 4
Nucleotide: 
NM_016129
Alias: 
CSN4;
Ensembl: 
ENSG00000138663
Location: 
4q21.22
HPRD: 
09888
NCBI Gene: 
51138
MIM: 

Summary: 
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Function: 
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Subcellular location: 
Cytoplasm. Nucleus .
PTM: 
Acetylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP56841_P050 COPS4 antibody - middle region (ARP56841_P050) Polyclonal Guinea pig, Horse, Human, Mouse WB 50ug $289 Details
Polyclonal Antibody OAEB00348 Goat anti-COPS4 Antibody (0.1mg) ELISA 0.1mg $190 Details
Polyclonal Antibody ARP56840_P050 Cops4 antibody - N-terminal region (ARP56840_P050) Guinea pig, Horse, Human, Mouse WB 50ug $289 Details

Show all Cops4 antibodies


Product Images
Cops4 antibody - N-terminal region (ARP56840_P050) in Rat Lung cells using Western Blot

Sample Type: Rat Lung

COPS4 antibody - middle region (ARP56841_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2


Cops4 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP56840 Bovine Cops4 antibody; Bos taurus Cops4 antibody Q3SZA0 100.0%
ARP56840 Cat Cops4 antibody; Felis catus Cops4 antibody M3XBM5 100.0%
ARP56840 Chicken Cops4 antibody; Gallus gallus Cops4 antibody Q5ZJV0 92.0%
ARP56840 Chimpanzee Cops4 antibody; Pan troglodytes Cops4 antibody H2QPT3 100.0%
ARP56840 Chinese softshell turtle Cops4 antibody; Pelodiscus sinensis Cops4 antibody K7GEE5 100.0%
ARP56840 Collared flycatcher Cops4 antibody; Ficedula albicollis Cops4 antibody U3JSV6 92.0%
ARP56840 Collared flycatcher Cops4 antibody; Ficedula albicollis Cops4 antibody U3JSW1 92.0%
ARP56840 Common turkey Cops4 antibody; Meleagris gallopavo Cops4 antibody G1N797 92.0%
ARP56840 Crab-eating macaque Cops4 antibody; Macaca fascicularis Cops4 antibody Q4R5E6 100.0%
ARP56840 Dog Cops4 antibody; Canis familiaris Cops4 antibody E2RT55 100.0%
ARP56840 Domestic duck Cops4 antibody; Anas platyrhynchos Cops4 antibody U3IQD8 85.0%
ARP56840 European domestic ferret Cops4 antibody; Mustela putorius furo Cops4 antibody M3YTD9 100.0%
ARP56840 Giant panda Cops4 antibody; Ailuropoda melanoleuca Cops4 antibody G1LEI1 100.0%
ARP56840 Gray short-tailed opossum Cops4 antibody; Monodelphis domestica Cops4 antibody F6YAS4 100.0%
ARP56840 Horse Cops4 antibody; Equus caballus Cops4 antibody F6TMH1 100.0%
ARP56840 Human Cops4 antibody; Homo sapiens Cops4 antibody Q9BT78-2 100.0%
ARP56840 Human Cops4 antibody; Homo sapiens Cops4 antibody Q9BT78 100.0%
ARP56840 Human Cops4 antibody; Homo sapiens Cops4 antibody D6RAX7 100.0%
ARP56840 Human Cops4 antibody; Homo sapiens Cops4 antibody D6RFN0 100.0%
ARP56840 Mouse Cops4 antibody; Mus musculus Cops4 antibody Q3TIJ1 100.0%
ARP56840 Mouse Cops4 antibody; Mus musculus Cops4 antibody D3YV99 100.0%
ARP56840 Mouse Cops4 antibody; Mus musculus Cops4 antibody D3Z1R9 100.0%
ARP56840 Mouse Cops4 antibody; Mus musculus Cops4 antibody O88544 100.0%
ARP56840 Mouse Cops4 antibody; Mus musculus Cops4 antibody Q14AI7 100.0%
ARP56840 Northern white-cheeked gibbon Cops4 antibody; Nomascus leucogenys Cops4 antibody G1RCM0 100.0%
ARP56840 Pig Cops4 antibody; Sus scrofa Cops4 antibody A7Y521 100.0%
ARP56840 Rabbit Cops4 antibody; Oryctolagus cuniculus Cops4 antibody G1SJN4 100.0%
ARP56840 Rat Cops4 antibody; Rattus norvegicus Cops4 antibody Q68FS2 100.0%
ARP56840 Rhesus macaque Cops4 antibody; Macaca mulatta Cops4 antibody F6XE81 100.0%
ARP56840 Small-eared galago Cops4 antibody; Otolemur garnettii Cops4 antibody H0XIC7 100.0%
ARP56840 Spotted green pufferfish Cops4 antibody; Tetraodon nigroviridis Cops4 antibody H3D7J9 92.0%
ARP56840 Sumatran orangutan Cops4 antibody; Pongo abelii Cops4 antibody Q5R648 100.0%
ARP56840 Sumatran orangutan Cops4 antibody; Pongo abelii Cops4 antibody H2PDS7 100.0%
ARP56840 Tasmanian devil Cops4 antibody; Sarcophilus harrisii Cops4 antibody G3W0X5 100.0%
ARP56840 Thirteen-lined ground squirrel Cops4 antibody; Spermophilus tridecemlineatus Cops4 antibody I3MWC6 100.0%
ARP56840 White-tufted-ear marmoset Cops4 antibody; Callithrix jacchus Cops4 antibody U3FN66 100.0%
ARP56840 White-tufted-ear marmoset Cops4 antibody; Callithrix jacchus Cops4 antibody F7EH98 100.0%
ARP56840 Zebra finch Cops4 antibody; Taeniopygia guttata Cops4 antibody H0YX45 92.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas218042_at721_B_lymphoblasts163.90062.360Details
BioGPS Gene Atlas218042_atAdipocyte47.40062.360Details
BioGPS Gene Atlas218042_atAdrenalCortex4.95062.360Details
BioGPS Gene Atlas218042_atAdrenalgland9.20062.360Details
BioGPS Gene Atlas218042_atAmygdala164.50062.360Details
BioGPS Gene Atlas218042_atAppendix13.65062.360Details
BioGPS Gene Atlas218042_atAtrioventricularNode6.70062.360Details
BioGPS Gene Atlas218042_atBDCA4+_DentriticCells71.50062.360Details
BioGPS Gene Atlas218042_atBonemarrow8.55062.360Details
BioGPS Gene Atlas218042_atBronchialEpithelialCells136.20062.360Details
BioGPS Gene Atlas218042_atCD105+_Endothelial74.70062.360Details
BioGPS Gene Atlas218042_atCD14+_Monocytes64.70062.360Details
BioGPS Gene Atlas218042_atCD19+_BCells(neg._sel.)70.25062.360Details
BioGPS Gene Atlas218042_atCD33+_Myeloid30.50062.360Details
BioGPS Gene Atlas218042_atCD34+52.05062.360Details
BioGPS Gene Atlas218042_atCD4+_Tcells48.95062.360Details
BioGPS Gene Atlas218042_atCD56+_NKCells74.95062.360Details
BioGPS Gene Atlas218042_atCD71+_EarlyErythroid29.65062.360Details
BioGPS Gene Atlas218042_atCD8+_Tcells65.40062.360Details
BioGPS Gene Atlas218042_atCardiacMyocytes66.90062.360Details
BioGPS Gene Atlas218042_atCaudatenucleus63.05062.360Details
BioGPS Gene Atlas218042_atCerebellum15.25062.360Details
BioGPS Gene Atlas218042_atCerebellumPeduncles7.90062.360Details
BioGPS Gene Atlas218042_atCiliaryGanglion3.25062.360Details
BioGPS Gene Atlas218042_atCingulateCortex51.15062.360Details
BioGPS Gene Atlas218042_atColorectaladenocarcinoma8.80062.360Details
BioGPS Gene Atlas218042_atDorsalRootGanglion6.15062.360Details
BioGPS Gene Atlas218042_atFetalThyroid37.60062.360Details
BioGPS Gene Atlas218042_atFetalbrain80.50062.360Details
BioGPS Gene Atlas218042_atFetalliver34.05062.360Details
BioGPS Gene Atlas218042_atFetallung47.80062.360Details
BioGPS Gene Atlas218042_atGlobusPallidus32.20062.360Details
BioGPS Gene Atlas218042_atHeart5.45062.360Details
BioGPS Gene Atlas218042_atHypothalamus172.85062.360Details
BioGPS Gene Atlas218042_atKidney15.75062.360Details
BioGPS Gene Atlas218042_atLeukemia_chronicMyelogenousK-56242.70062.360Details
BioGPS Gene Atlas218042_atLeukemia_promyelocytic-HL-6039.85062.360Details
BioGPS Gene Atlas218042_atLeukemialymphoblastic(MOLT-4)94.75062.360Details
BioGPS Gene Atlas218042_atLiver5.75062.360Details
BioGPS Gene Atlas218042_atLung8.90062.360Details
BioGPS Gene Atlas218042_atLymphnode24.05062.360Details
BioGPS Gene Atlas218042_atLymphoma_burkitts(Daudi)152.35062.360Details
BioGPS Gene Atlas218042_atLymphoma_burkitts(Raji)12.20062.360Details
BioGPS Gene Atlas218042_atMedullaOblongata47.35062.360Details
BioGPS Gene Atlas218042_atOccipitalLobe92.95062.360Details
BioGPS Gene Atlas218042_atOlfactoryBulb16.65062.360Details
BioGPS Gene Atlas218042_atOvary12.60062.360Details
BioGPS Gene Atlas218042_atPancreas11.85062.360Details
BioGPS Gene Atlas218042_atPancreaticIslet69.95062.360Details
BioGPS Gene Atlas218042_atParietalLobe46.95062.360Details
BioGPS Gene Atlas218042_atPituitary193.75062.360Details
BioGPS Gene Atlas218042_atPlacenta36.20062.360Details
BioGPS Gene Atlas218042_atPons44.50062.360Details
BioGPS Gene Atlas218042_atPrefrontalCortex86.95062.360Details
BioGPS Gene Atlas218042_atProstate18.55062.360Details
BioGPS Gene Atlas218042_atSalivarygland14.95062.360Details
BioGPS Gene Atlas218042_atSkeletalMuscle5.20062.360Details
BioGPS Gene Atlas218042_atSkin3.90062.360Details
BioGPS Gene Atlas218042_atSmoothMuscle122.90062.360Details
BioGPS Gene Atlas218042_atSpinalcord67.45062.360Details
BioGPS Gene Atlas218042_atSubthalamicNucleus26.00062.360Details
BioGPS Gene Atlas218042_atSuperiorCervicalGanglion7.10062.360Details
BioGPS Gene Atlas218042_atTemporalLobe60.50062.360Details
BioGPS Gene Atlas218042_atTestis48.35062.360Details
BioGPS Gene Atlas218042_atTestisGermCell110.90062.360Details
BioGPS Gene Atlas218042_atTestisIntersitial92.40062.360Details
BioGPS Gene Atlas218042_atTestisLeydigCell53.25062.360Details
BioGPS Gene Atlas218042_atTestisSeminiferousTubule48.70062.360Details
BioGPS Gene Atlas218042_atThalamus102.45062.360Details
BioGPS Gene Atlas218042_atThymus27.45062.360Details
BioGPS Gene Atlas218042_atThyroid141.65062.360Details
BioGPS Gene Atlas218042_atTongue12.75062.360Details
BioGPS Gene Atlas218042_atTonsil23.75062.360Details
BioGPS Gene Atlas218042_atTrachea27.80062.360Details
BioGPS Gene Atlas218042_atTrigeminalGanglion10.15062.360Details
BioGPS Gene Atlas218042_atUterus60.40062.360Details
BioGPS Gene Atlas218042_atUterusCorpus11.65062.360Details
BioGPS Gene Atlas218042_atWholeBlood55.90062.360Details
BioGPS Gene Atlas218042_atWholebrain95.15062.360Details
BioGPS Gene Atlas218042_atcolon35.90062.360Details
BioGPS Gene Atlas218042_atpineal_day235.32062.360Details
BioGPS Gene Atlas218042_atpineal_night259.66062.360Details
BioGPS Gene Atlas218042_atretina54.87562.360Details
BioGPS Gene Atlas218042_atsmall_intestine29.05062.360Details
BioGPS NCI60218042_at7861145.900790.350Details
BioGPS NCI60218042_atA172730.872790.350Details
BioGPS NCI60218042_atA204316.131790.350Details
BioGPS NCI60218042_atA361319.028790.350Details
BioGPS NCI60218042_atA498459.560790.350Details
BioGPS NCI60218042_atA549516.129790.350Details
BioGPS NCI60218042_atACC3333.918790.350Details
BioGPS NCI60218042_atACHN411.808790.350Details
BioGPS NCI60218042_atALVA311182.427790.350Details
BioGPS NCI60218042_atCAKI1781.224790.350Details
BioGPS NCI60218042_atCCRT CEM444.176790.350Details
BioGPS NCI60218042_atCOLO2051105.531790.350Details
BioGPS NCI60218042_atDLD11519.055790.350Details
BioGPS NCI60218042_atDU145627.402790.350Details
BioGPS NCI60218042_atEKVX1342.621790.350Details
BioGPS NCI60218042_atGM1331212.949790.350Details
BioGPS NCI60218042_atGM1600605.533790.350Details
BioGPS NCI60218042_atGM2313823.885790.350Details
BioGPS NCI60218042_atGM2345521.058790.350Details
BioGPS NCI60218042_atGM2493796.420790.350Details
BioGPS NCI60218042_atGM97373.123790.350Details
BioGPS NCI60218042_atHCC2998863.063790.350Details
BioGPS NCI60218042_atHCT1161777.876790.350Details
BioGPS NCI60218042_atHCT152052.278790.350Details
BioGPS NCI60218042_atHEK 293 T-rex863.778790.350Details
BioGPS NCI60218042_atHEK 293T1249.602790.350Details
BioGPS NCI60218042_atHEK293632.957790.350Details
BioGPS NCI60218042_atHELA970.410790.350Details
BioGPS NCI60218042_atHEPG2419.423790.350Details
BioGPS NCI60218042_atHL60264.509790.350Details
BioGPS NCI60218042_atHOP62337.722790.350Details
BioGPS NCI60218042_atHOP92422.468790.350Details
BioGPS NCI60218042_atHS578T739.281790.350Details
BioGPS NCI60218042_atHSG404.721790.350Details
BioGPS NCI60218042_atHT1080955.113790.350Details
BioGPS NCI60218042_atHT29502.335790.350Details
BioGPS NCI60218042_atIGROV1670.025790.350Details
BioGPS NCI60218042_atIOSE80930.962790.350Details
BioGPS NCI60218042_atJURKAT1423.379790.350Details
BioGPS NCI60218042_atK562519.629790.350Details
BioGPS NCI60218042_atKM12692.715790.350Details
BioGPS NCI60218042_atLN18762.005790.350Details
BioGPS NCI60218042_atLNCAP941.294790.350Details
BioGPS NCI60218042_atLOX IMVI473.867790.350Details
BioGPS NCI60218042_atM14389.495790.350Details
BioGPS NCI60218042_atMALME 3M187.624790.350Details
BioGPS NCI60218042_atMCF71067.575790.350Details
BioGPS NCI60218042_atMD MB2311008.753790.350Details
BioGPS NCI60218042_atMDA MB435750.078790.350Details
BioGPS NCI60218042_atMOLT41395.727790.350Details
BioGPS NCI60218042_atNCI 460522.917790.350Details
BioGPS NCI60218042_atNCI H226563.822790.350Details
BioGPS NCI60218042_atNCI H231047.062790.350Details
BioGPS NCI60218042_atNCI H322M890.649790.350Details
BioGPS NCI60218042_atNCVADR RES1101.738790.350Details
BioGPS NCI60218042_atOVCAR3640.571790.350Details
BioGPS NCI60218042_atOVCAR4748.492790.350Details
BioGPS NCI60218042_atOVCAR5639.728790.350Details
BioGPS NCI60218042_atOVCAR8967.885790.350Details
BioGPS NCI60218042_atPANC11043.365790.350Details
BioGPS NCI60218042_atRL71290.240790.350Details
BioGPS NCI60218042_atRPMI 8226327.836790.350Details
BioGPS NCI60218042_atRS11846751.713790.350Details
BioGPS NCI60218042_atRXF393505.912790.350Details
BioGPS NCI60218042_atSAOS2885.569790.350Details
BioGPS NCI60218042_atSF268747.129790.350Details
BioGPS NCI60218042_atSF2951212.360790.350Details
BioGPS NCI60218042_atSF539634.511790.350Details
BioGPS NCI60218042_atSHSYSY+RA467.295790.350Details
BioGPS NCI60218042_atSHSYSY-RA381.732790.350Details
BioGPS NCI60218042_atSKMEL2578.739790.350Details
BioGPS NCI60218042_atSKMEL28259.848790.350Details
BioGPS NCI60218042_atSKMEL5536.756790.350Details
BioGPS NCI60218042_atSKOV32716.269790.350Details
BioGPS NCI60218042_atSN12C943.413790.350Details
BioGPS NCI60218042_atSNB19695.391790.350Details
BioGPS NCI60218042_atSNB75409.004790.350Details
BioGPS NCI60218042_atSR688.227790.350Details
BioGPS NCI60218042_atSW620872.775790.350Details
BioGPS NCI60218042_atT24746.624790.350Details
BioGPS NCI60218042_atT3M4427.005790.350Details
BioGPS NCI60218042_atTK10456.320790.350Details
BioGPS NCI60218042_atU118971.975790.350Details
BioGPS NCI60218042_atU1381276.642790.350Details
BioGPS NCI60218042_atU20S931.855790.350Details
BioGPS NCI60218042_atU251505.927790.350Details
BioGPS NCI60218042_atU871198.535790.350Details
BioGPS NCI60218042_atUACC257202.331790.350Details
BioGPS NCI60218042_atUACC62410.501790.350Details
BioGPS NCI60218042_atUO31755.477790.350Details
BioGPS NCI60218042_atZR75_1639.151790.350Details
BioGPS NCI60218042_atastrocytes643.686790.350Details
BioGPS NCI60218042_athuh-7484.339790.350Details