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Gene ID: 84570 | COL25A1 Antibody Resource


COL25A1 Antibody Resource
Gene Full Name: 
collagen, type XXV, alpha 1
Uniprot: 
Q9BXS0
Protein Name: 
collagen alpha-1(XXV) chain
Nucleotide: 
NM_198721
Alias: 
AMY;CLAC;CLACP;CLAC-P;
Ensembl: 
ENSG00000188517
Location: 
4q25
HPRD: 
09886
NCBI Gene: 
84570
MIM: 
610004

Summary: 
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Function: 
Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Subcellular location: 
Membrane; Single-pass type II membrane protein Potential. Note: After proteolytic cleavage, CLAC is secreted.
PTM: 
Glycoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP50077_P050 COL25A1 antibody - middle region (ARP50077_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit WB 50ug $289 Details
Polyclonal Antibody OAAB04087 COL25A1 antibody - N-terminal region (OAAB04087) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody ARP50076_P050 COL25A1 Antibody (ARP50076_P050) Polyclonal Horse, Human, Mouse, Rabbit, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody OAAF02925 COL25A1 Antibody (OAAF02925) Polyclonal Human, Mouse WB, ELISA 100 ug $229 Details

Show all COL25A1 antibodies


Product Images
COL25A1 antibody - middle region (ARP50077_P050) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

COL25A1 Antibody (OAAF02925) in Jurkat, A549 cells using Western Blot

Sample Type: Jurkat, A549


COL25A1 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP64034 Cat COL25A1 antibody; Felis catus COL25A1 antibody M3W0B2 79.0%
ARP64034 Chicken COL25A1 antibody; Gallus gallus COL25A1 antibody F1NNK8 92.0%
ARP50076 Chicken COL25A1 antibody; Gallus gallus COL25A1 antibody F1NNK8 86.0%
ARP50076 Chimpanzee COL25A1 antibody; Pan troglodytes COL25A1 antibody H2R037 100.0%
ARP60026 Chinese softshell turtle COL25A1 antibody; Pelodiscus sinensis COL25A1 antibody K7F5G2 92.0%
ARP64034 Chinese softshell turtle COL25A1 antibody; Pelodiscus sinensis COL25A1 antibody K7F5G2 92.0%
ARP60009 Chinese softshell turtle COL25A1 antibody; Pelodiscus sinensis COL25A1 antibody K7F5G2 83.0%
ARP64034 Collared flycatcher COL25A1 antibody; Ficedula albicollis COL25A1 antibody U3KCK4 92.0%
ARP50076 Dog COL25A1 antibody; Canis familiaris COL25A1 antibody J9NST2 100.0%
ARP67054 Dog COL25A1 antibody; Canis familiaris COL25A1 antibody J9NST2 85.0%
ARP67054 Dog COL25A1 antibody; Canis familiaris COL25A1 antibody F1Q0G8 85.0%
ARP64034 Domestic duck COL25A1 antibody; Anas platyrhynchos COL25A1 antibody U3IMA6 92.0%
ARP50076 Domestic duck COL25A1 antibody; Anas platyrhynchos COL25A1 antibody U3IMA6 86.0%
ARP64034 Duckbill platypus COL25A1 antibody; Ornithorhynchus anatinus COL25A1 antibody F7F872 79.0%
ARP64034 European domestic ferret COL25A1 antibody; Mustela putorius furo COL25A1 antibody M3YBA3 79.0%
ARP50076 Gray short-tailed opossum COL25A1 antibody; Monodelphis domestica COL25A1 antibody F7A0K9 93.0%
ARP60009 Gray short-tailed opossum COL25A1 antibody; Monodelphis domestica COL25A1 antibody F7A0K9 91.0%
ARP64034 Gray short-tailed opossum COL25A1 antibody; Monodelphis domestica COL25A1 antibody F7A0K9 79.0%
ARP60009 Green anole COL25A1 antibody; Anolis carolinensis COL25A1 antibody G1KML9 83.0%
ARP64034 Green anole COL25A1 antibody; Anolis carolinensis COL25A1 antibody G1KML9 79.0%
ARP50076 Human COL25A1 antibody; Homo sapiens COL25A1 antibody A8MWQ5 100.0%
ARP50076 Human COL25A1 antibody; Homo sapiens COL25A1 antibody E9PNV9 100.0%
ARP50076 Human COL25A1 antibody; Homo sapiens COL25A1 antibody Q8NE08 100.0%
ARP50076 Human COL25A1 antibody; Homo sapiens COL25A1 antibody Q9BXS0-2 100.0%
ARP50076 Human COL25A1 antibody; Homo sapiens COL25A1 antibody Q9BXS0-3 100.0%
ARP50076 Human COL25A1 antibody; Homo sapiens COL25A1 antibody Q9BXS0 100.0%
ARP60021 Human COL25A1 antibody; Homo sapiens COL25A1 antibody A8MWQ5 85.0%
ARP60026 Human COL25A1 antibody; Homo sapiens COL25A1 antibody A8MWQ5 85.0%
ARP50076 Mouse COL25A1 antibody; Mus musculus COL25A1 antibody A0PJC4 100.0%
ARP50076 Mouse COL25A1 antibody; Mus musculus COL25A1 antibody B2RQR7 100.0%
ARP50076 Mouse COL25A1 antibody; Mus musculus COL25A1 antibody E9Q5L6 100.0%
ARP50076 Mouse COL25A1 antibody; Mus musculus COL25A1 antibody Q99MQ5 100.0%
ARP60009 Mouse COL25A1 antibody; Mus musculus COL25A1 antibody B2RQR7 91.0%
ARP60009 Mouse COL25A1 antibody; Mus musculus COL25A1 antibody E9Q5L6 91.0%
ARP60009 Mouse COL25A1 antibody; Mus musculus COL25A1 antibody Q99MQ5 91.0%
ARP50076 Northern white-cheeked gibbon COL25A1 antibody; Nomascus leucogenys COL25A1 antibody G1RQZ7 100.0%
ARP50076 Rabbit COL25A1 antibody; Oryctolagus cuniculus COL25A1 antibody G1SCU0 100.0%
ARP50076 Rabbit COL25A1 antibody; Oryctolagus cuniculus COL25A1 antibody G1U5C8 100.0%
ARP60009 Rat COL25A1 antibody; Rattus norvegicus COL25A1 antibody M0R513 91.0%
ARP60009 Rat COL25A1 antibody; Rattus norvegicus COL25A1 antibody M0RAM0 91.0%
ARP60009 Rat COL25A1 antibody; Rattus norvegicus COL25A1 antibody M0RDG5 91.0%
ARP65741 Rat COL25A1 antibody; Rattus norvegicus COL25A1 antibody M0R513 79.0%
ARP65741 Rat COL25A1 antibody; Rattus norvegicus COL25A1 antibody M0RAM0 79.0%
ARP65741 Rat COL25A1 antibody; Rattus norvegicus COL25A1 antibody M0RDG5 79.0%
ARP50076 Rhesus macaque COL25A1 antibody; Macaca mulatta COL25A1 antibody F6U3E2 100.0%
ARP50076 Rhesus macaque COL25A1 antibody; Macaca mulatta COL25A1 antibody F6U3F4 100.0%
ARP50076 Southern platyfish COL25A1 antibody; Xiphophorus maculatus COL25A1 antibody M4A201 79.0%
ARP50076 Spotted green pufferfish COL25A1 antibody; Tetraodon nigroviridis COL25A1 antibody H3CP01 86.0%
ARP50076 Sumatran orangutan COL25A1 antibody; Pongo abelii COL25A1 antibody H2PE33 100.0%
ARP64034 Tasmanian devil COL25A1 antibody; Sarcophilus harrisii COL25A1 antibody G3VWK5 85.0%
ARP60026 Tasmanian devil COL25A1 antibody; Sarcophilus harrisii COL25A1 antibody G3VWK6 85.0%
ARP64034 Tasmanian devil COL25A1 antibody; Sarcophilus harrisii COL25A1 antibody G3VWK6 85.0%
ARP60026 Tasmanian devil COL25A1 antibody; Sarcophilus harrisii COL25A1 antibody G3VWK4 85.0%
ARP64034 Tasmanian devil COL25A1 antibody; Sarcophilus harrisii COL25A1 antibody G3VWK4 85.0%
ARP60026 Tasmanian devil COL25A1 antibody; Sarcophilus harrisii COL25A1 antibody G3VWK5 85.0%
ARP50076 White-tufted-ear marmoset COL25A1 antibody; Callithrix jacchus COL25A1 antibody U3CJE7 100.0%
ARP64034 Zebra finch COL25A1 antibody; Taeniopygia guttata COL25A1 antibody H0Z0W8 100.0%
ARP50076 Zebra finch COL25A1 antibody; Taeniopygia guttata COL25A1 antibody H0Z0X0 86.0%

Tissue & Cell Line Gene Expression Data