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Gene ID: 54714 | CNGB3 Antibody Resource


CNGB3 Antibody Resource
Gene Full Name: 
cyclic nucleotide gated channel beta 3
Uniprot: 
Q9NQW8
Protein Name: 
cyclic nucleotide-gated cation channel beta-3
Nucleotide: 
NM_019098
Alias: 
ACHM1;
Ensembl: 
ENSG00000170289
Location: 
8q21.3
HPRD: 
05468
NCBI Gene: 
54714
MIM: 
605080

Summary: 
This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]
Function: 
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 . Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Subcellular location: 
Membrane; Multi-pass membrane protein.
PTM: 
Glycoprotein;
Disease: 
Stargardt disease 1 (STGD1) [MIM:248200]: A common hereditary macular degeneration. It is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. Note: The disease is caused by mutations affecting the gene represented in this entry. Achromatopsia 3 (ACHM3) [MIM:262300]: An ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. Achromatopsia type 3 patients manifest severe myopia. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP35295_P050 CNGB3 Antibody (ARP35295_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Rabbit, Rat, Sheep Not tested 50 ug $125 Details
Polyclonal Antibody OAAB08990 CNGB3 antibody - N - terminal region (OAAB08990) Human WB 400ul $289 Details

Show all CNGB3 antibodies


Product Images
CNGB3 antibody - N - terminal region (OAAB08990) in MDA-MB435 cells using Western Blot

Sample Type: MDA-MB435


CNGB3 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP35295 Bovine CNGB3 antibody; Bos taurus CNGB3 antibody F1MZC9 79.0%
ARP35295 Bovine CNGB3 antibody; Bos taurus CNGB3 antibody G3MXA9 79.0%
ARP35295 Cat CNGB3 antibody; Felis catus CNGB3 antibody M3WJ72 79.0%
ARP35295 Chimpanzee CNGB3 antibody; Pan troglodytes CNGB3 antibody H2QWE1 100.0%
ARP35295 Dog CNGB3 antibody; Canis familiaris CNGB3 antibody F1Q3J5 79.0%
ARP35295 Dog CNGB3 antibody; Canis familiaris CNGB3 antibody J9NRR5 79.0%
ARP35295 Dog CNGB3 antibody; Canis familiaris CNGB3 antibody Q8MJD7 79.0%
ARP59946 Domestic duck CNGB3 antibody; Anas platyrhynchos CNGB3 antibody U3J7B5 86.0%
ARP35295 European domestic ferret CNGB3 antibody; Mustela putorius furo CNGB3 antibody M3YHL8 79.0%
ARP35295 Giant panda CNGB3 antibody; Ailuropoda melanoleuca CNGB3 antibody G1L7X8 79.0%
ARP35295 Horse CNGB3 antibody; Equus caballus CNGB3 antibody F6VJ92 86.0%
ARP35295 Human CNGB3 antibody; Homo sapiens CNGB3 antibody Q9NQW8-2 100.0%
ARP35295 Human CNGB3 antibody; Homo sapiens CNGB3 antibody Q9NQW8 100.0%
ARP35295 Human CNGB3 antibody; Homo sapiens CNGB3 antibody B9EK43 100.0%
ARP35295 Northern white-cheeked gibbon CNGB3 antibody; Nomascus leucogenys CNGB3 antibody G1QMF6 100.0%
ARP35295 Rabbit CNGB3 antibody; Oryctolagus cuniculus CNGB3 antibody G1TEU9 79.0%
ARP35295 Rat CNGB3 antibody; Rattus norvegicus CNGB3 antibody F1LX27 79.0%
ARP35295 Rhesus macaque CNGB3 antibody; Macaca mulatta CNGB3 antibody F6Q6B2 86.0%
ARP35295 Rhesus macaque CNGB3 antibody; Macaca mulatta CNGB3 antibody F7F1T7 86.0%
ARP35295 Sheep CNGB3 antibody; Ovis aries CNGB3 antibody B7VGH2 79.0%
ARP35295 Small-eared galago CNGB3 antibody; Otolemur garnettii CNGB3 antibody H0X681 79.0%
ARP35295 White-tufted-ear marmoset CNGB3 antibody; Callithrix jacchus CNGB3 antibody F7G1E6 93.0%
ARP35295 White-tufted-ear marmoset CNGB3 antibody; Callithrix jacchus CNGB3 antibody F7G1F2 93.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas220304_s_at721_B_lymphoblasts9.60020.560Details
BioGPS Gene Atlas220304_s_atAdipocyte11.75020.560Details
BioGPS Gene Atlas220304_s_atAdrenalCortex14.15020.560Details
BioGPS Gene Atlas220304_s_atAdrenalgland11.35020.560Details
BioGPS Gene Atlas220304_s_atAmygdala12.10020.560Details
BioGPS Gene Atlas220304_s_atAppendix19.40020.560Details
BioGPS Gene Atlas220304_s_atAtrioventricularNode13.20020.560Details
BioGPS Gene Atlas220304_s_atBDCA4+_DentriticCells9.35020.560Details
BioGPS Gene Atlas220304_s_atBonemarrow13.85020.560Details
BioGPS Gene Atlas220304_s_atBronchialEpithelialCells10.30020.560Details
BioGPS Gene Atlas220304_s_atCD105+_Endothelial12.80020.560Details
BioGPS Gene Atlas220304_s_atCD14+_Monocytes12.55020.560Details
BioGPS Gene Atlas220304_s_atCD19+_BCells(neg._sel.)10.55020.560Details
BioGPS Gene Atlas220304_s_atCD33+_Myeloid15.25020.560Details
BioGPS Gene Atlas220304_s_atCD34+14.65020.560Details
BioGPS Gene Atlas220304_s_atCD4+_Tcells9.45020.560Details
BioGPS Gene Atlas220304_s_atCD56+_NKCells10.90020.560Details
BioGPS Gene Atlas220304_s_atCD71+_EarlyErythroid11.20020.560Details
BioGPS Gene Atlas220304_s_atCD8+_Tcells8.30020.560Details
BioGPS Gene Atlas220304_s_atCardiacMyocytes19.95020.560Details
BioGPS Gene Atlas220304_s_atCaudatenucleus13.05020.560Details
BioGPS Gene Atlas220304_s_atCerebellum21.55020.560Details
BioGPS Gene Atlas220304_s_atCerebellumPeduncles16.65020.560Details
BioGPS Gene Atlas220304_s_atCiliaryGanglion12.40020.560Details
BioGPS Gene Atlas220304_s_atCingulateCortex13.60020.560Details
BioGPS Gene Atlas220304_s_atColorectaladenocarcinoma11.40020.560Details
BioGPS Gene Atlas220304_s_atDorsalRootGanglion12.80020.560Details
BioGPS Gene Atlas220304_s_atFetalThyroid12.25020.560Details
BioGPS Gene Atlas220304_s_atFetalbrain12.80020.560Details
BioGPS Gene Atlas220304_s_atFetalliver10.95020.560Details
BioGPS Gene Atlas220304_s_atFetallung10.10020.560Details
BioGPS Gene Atlas220304_s_atGlobusPallidus11.75020.560Details
BioGPS Gene Atlas220304_s_atHeart19.85020.560Details
BioGPS Gene Atlas220304_s_atHypothalamus11.85020.560Details
BioGPS Gene Atlas220304_s_atKidney16.55020.560Details
BioGPS Gene Atlas220304_s_atLeukemia_chronicMyelogenousK-56211.15020.560Details
BioGPS Gene Atlas220304_s_atLeukemia_promyelocytic-HL-6010.55020.560Details
BioGPS Gene Atlas220304_s_atLeukemialymphoblastic(MOLT-4)9.45020.560Details
BioGPS Gene Atlas220304_s_atLiver19.35020.560Details
BioGPS Gene Atlas220304_s_atLung12.10020.560Details
BioGPS Gene Atlas220304_s_atLymphnode10.00020.560Details
BioGPS Gene Atlas220304_s_atLymphoma_burkitts(Daudi)16.80020.560Details
BioGPS Gene Atlas220304_s_atLymphoma_burkitts(Raji)17.50020.560Details
BioGPS Gene Atlas220304_s_atMedullaOblongata13.85020.560Details
BioGPS Gene Atlas220304_s_atOccipitalLobe11.70020.560Details
BioGPS Gene Atlas220304_s_atOlfactoryBulb10.00020.560Details
BioGPS Gene Atlas220304_s_atOvary10.65020.560Details
BioGPS Gene Atlas220304_s_atPancreas9.80020.560Details
BioGPS Gene Atlas220304_s_atPancreaticIslet13.00020.560Details
BioGPS Gene Atlas220304_s_atParietalLobe20.20020.560Details
BioGPS Gene Atlas220304_s_atPituitary15.70020.560Details
BioGPS Gene Atlas220304_s_atPlacenta11.65020.560Details
BioGPS Gene Atlas220304_s_atPons16.40020.560Details
BioGPS Gene Atlas220304_s_atPrefrontalCortex11.50020.560Details
BioGPS Gene Atlas220304_s_atProstate13.00020.560Details
BioGPS Gene Atlas220304_s_atSalivarygland9.95020.560Details
BioGPS Gene Atlas220304_s_atSkeletalMuscle23.10020.560Details
BioGPS Gene Atlas220304_s_atSkin12.55020.560Details
BioGPS Gene Atlas220304_s_atSmoothMuscle13.15020.560Details
BioGPS Gene Atlas220304_s_atSpinalcord13.50020.560Details
BioGPS Gene Atlas220304_s_atSubthalamicNucleus12.90020.560Details
BioGPS Gene Atlas220304_s_atSuperiorCervicalGanglion34.60020.560Details
BioGPS Gene Atlas220304_s_atTemporalLobe11.45020.560Details
BioGPS Gene Atlas220304_s_atTestis12.50020.560Details
BioGPS Gene Atlas220304_s_atTestisGermCell10.75020.560Details
BioGPS Gene Atlas220304_s_atTestisIntersitial11.40020.560Details
BioGPS Gene Atlas220304_s_atTestisLeydigCell12.90020.560Details
BioGPS Gene Atlas220304_s_atTestisSeminiferousTubule13.50020.560Details
BioGPS Gene Atlas220304_s_atThalamus12.80020.560Details
BioGPS Gene Atlas220304_s_atThymus9.95020.560Details
BioGPS Gene Atlas220304_s_atThyroid13.50020.560Details
BioGPS Gene Atlas220304_s_atTongue16.05020.560Details
BioGPS Gene Atlas220304_s_atTonsil12.05020.560Details
BioGPS Gene Atlas220304_s_atTrachea11.80020.560Details
BioGPS Gene Atlas220304_s_atTrigeminalGanglion25.00020.560Details
BioGPS Gene Atlas220304_s_atUterus8.90020.560Details
BioGPS Gene Atlas220304_s_atUterusCorpus17.20020.560Details
BioGPS Gene Atlas220304_s_atWholeBlood11.65020.560Details
BioGPS Gene Atlas220304_s_atWholebrain10.85020.560Details
BioGPS Gene Atlas220304_s_atcolon11.90020.560Details
BioGPS Gene Atlas220304_s_atpineal_day141.38020.560Details
BioGPS Gene Atlas220304_s_atpineal_night135.34020.560Details
BioGPS Gene Atlas220304_s_atretina15.32520.560Details
BioGPS Gene Atlas220304_s_atsmall_intestine10.50020.560Details
BioGPS NCI60220304_s_at78610.97211.220Details
BioGPS NCI60220304_s_atA1728.74611.220Details
BioGPS NCI60220304_s_atA20410.69311.220Details
BioGPS NCI60220304_s_atA36110.98911.220Details
BioGPS NCI60220304_s_atA49810.81511.220Details
BioGPS NCI60220304_s_atA54910.90511.220Details
BioGPS NCI60220304_s_atACC314.30011.220Details
BioGPS NCI60220304_s_atACHN10.03811.220Details
BioGPS NCI60220304_s_atALVA3116.29911.220Details
BioGPS NCI60220304_s_atCAKI112.19711.220Details
BioGPS NCI60220304_s_atCCRT CEM34.03411.220Details
BioGPS NCI60220304_s_atCOLO20510.54111.220Details
BioGPS NCI60220304_s_atDLD110.39011.220Details
BioGPS NCI60220304_s_atDU1459.57411.220Details
BioGPS NCI60220304_s_atEKVX8.73811.220Details
BioGPS NCI60220304_s_atGM13311.02111.220Details
BioGPS NCI60220304_s_atGM160011.58011.220Details
BioGPS NCI60220304_s_atGM231310.93311.220Details
BioGPS NCI60220304_s_atGM234510.23911.220Details
BioGPS NCI60220304_s_atGM249311.65211.220Details
BioGPS NCI60220304_s_atGM9712.74211.220Details
BioGPS NCI60220304_s_atHCC29988.01111.220Details
BioGPS NCI60220304_s_atHCT11610.66811.220Details
BioGPS NCI60220304_s_atHCT158.07611.220Details
BioGPS NCI60220304_s_atHEK 293 T-rex12.05311.220Details
BioGPS NCI60220304_s_atHEK 293T11.05911.220Details
BioGPS NCI60220304_s_atHEK29310.43111.220Details
BioGPS NCI60220304_s_atHELA9.02011.220Details
BioGPS NCI60220304_s_atHEPG210.83111.220Details
BioGPS NCI60220304_s_atHL6019.31411.220Details
BioGPS NCI60220304_s_atHOP6210.86811.220Details
BioGPS NCI60220304_s_atHOP929.37211.220Details
BioGPS NCI60220304_s_atHS578T13.01811.220Details
BioGPS NCI60220304_s_atHSG10.58411.220Details
BioGPS NCI60220304_s_atHT108010.10011.220Details
BioGPS NCI60220304_s_atHT2912.24211.220Details
BioGPS NCI60220304_s_atIGROV110.70111.220Details
BioGPS NCI60220304_s_atIOSE8010.64211.220Details
BioGPS NCI60220304_s_atJURKAT10.76211.220Details
BioGPS NCI60220304_s_atK56220.08411.220Details
BioGPS NCI60220304_s_atKM1211.49611.220Details
BioGPS NCI60220304_s_atLN188.01611.220Details
BioGPS NCI60220304_s_atLNCAP10.75411.220Details
BioGPS NCI60220304_s_atLOX IMVI10.41411.220Details
BioGPS NCI60220304_s_atM1410.68011.220Details
BioGPS NCI60220304_s_atMALME 3M18.07911.220Details
BioGPS NCI60220304_s_atMCF78.99911.220Details
BioGPS NCI60220304_s_atMD MB23111.30311.220Details
BioGPS NCI60220304_s_atMDA MB43513.92911.220Details
BioGPS NCI60220304_s_atMOLT411.75411.220Details
BioGPS NCI60220304_s_atNCI 46011.11511.220Details
BioGPS NCI60220304_s_atNCI H22611.59111.220Details
BioGPS NCI60220304_s_atNCI H2310.71811.220Details
BioGPS NCI60220304_s_atNCI H322M10.51611.220Details
BioGPS NCI60220304_s_atNCVADR RES9.00911.220Details
BioGPS NCI60220304_s_atOVCAR312.66311.220Details
BioGPS NCI60220304_s_atOVCAR410.19711.220Details
BioGPS NCI60220304_s_atOVCAR510.66311.220Details
BioGPS NCI60220304_s_atOVCAR89.02411.220Details
BioGPS NCI60220304_s_atPANC110.87211.220Details
BioGPS NCI60220304_s_atRL711.43711.220Details
BioGPS NCI60220304_s_atRPMI 822612.81011.220Details
BioGPS NCI60220304_s_atRS1184612.62711.220Details
BioGPS NCI60220304_s_atRXF39310.73311.220Details
BioGPS NCI60220304_s_atSAOS210.86811.220Details
BioGPS NCI60220304_s_atSF26810.22611.220Details
BioGPS NCI60220304_s_atSF29510.09211.220Details
BioGPS NCI60220304_s_atSF5399.00211.220Details
BioGPS NCI60220304_s_atSHSYSY+RA10.16611.220Details
BioGPS NCI60220304_s_atSHSYSY-RA10.72311.220Details
BioGPS NCI60220304_s_atSKMEL210.76211.220Details
BioGPS NCI60220304_s_atSKMEL2811.65011.220Details
BioGPS NCI60220304_s_atSKMEL59.59311.220Details
BioGPS NCI60220304_s_atSKOV310.97311.220Details
BioGPS NCI60220304_s_atSN12C10.37711.220Details
BioGPS NCI60220304_s_atSNB199.12711.220Details
BioGPS NCI60220304_s_atSNB7510.27011.220Details
BioGPS NCI60220304_s_atSR13.01311.220Details
BioGPS NCI60220304_s_atSW62010.95611.220Details
BioGPS NCI60220304_s_atT2410.96111.220Details
BioGPS NCI60220304_s_atT3M411.65211.220Details
BioGPS NCI60220304_s_atTK1010.44211.220Details
BioGPS NCI60220304_s_atU1189.76711.220Details
BioGPS NCI60220304_s_atU1388.31611.220Details
BioGPS NCI60220304_s_atU20S10.32111.220Details
BioGPS NCI60220304_s_atU2519.97311.220Details
BioGPS NCI60220304_s_atU878.46511.220Details
BioGPS NCI60220304_s_atUACC2579.91611.220Details
BioGPS NCI60220304_s_atUACC6211.55911.220Details
BioGPS NCI60220304_s_atUO318.84711.220Details
BioGPS NCI60220304_s_atZR75_113.48911.220Details
BioGPS NCI60220304_s_atastrocytes10.98011.220Details
BioGPS NCI60220304_s_athuh-712.03211.220Details