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Gene ID: 7401 | CLRN1 Antibody Resource


CLRN1 Antibody Resource
Gene Full Name: 
clarin 1
Uniprot: 
P58418
Protein Name: 
clarin-1
Nucleotide: 
NM_052995
Alias: 
RP61;USH3;USH3A;
Ensembl: 
ENSG00000163646
Location: 
3q25
HPRD: 
05905
NCBI Gene: 
7401
MIM: 
606397

Summary: 
This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Function: 
May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.
Subcellular location: 
Membrane; Multi-pass membrane protein Potential.
PTM: 
Glycoprotein;
Disease: 
Usher syndrome 3A (USH3A) [MIM:276902]: USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH3 is characterized by postlingual, progressive hearing loss, variable vestibular dysfunction, and onset of retinitis pigmentosa symptoms, including nyctalopia, constriction of the visual fields, and loss of central visual acuity, usually by the second decade of life. Note: The disease is caused by mutations affecting the gene represented in this entry. Retinitis pigmentosa 61 (RP61) [MIM:614180]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP59580_P050 CLRN1 antibody - C-terminal region (ARP59580_P050) Polyclonal Bovine, Dog, Human, Mouse, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody OAAB04335 CLRN1 antibody - C-terminal region (OAAB04335) Human WB, IHC, ELISA 400ul $289 Details

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Product Images
CLRN1 antibody - C-terminal region (ARP59580_P050) in Human Brain cells using Western Blot

Sample Type: Human Brain


CLRN1 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59580 Bovine CLRN1 antibody; Bos taurus CLRN1 antibody E1BDG3 86.0%
ARP59580 Cat CLRN1 antibody; Felis catus CLRN1 antibody M3WD68 93.0%
ARP59580 Chimpanzee CLRN1 antibody; Pan troglodytes CLRN1 antibody H2RE67 100.0%
ARP59580 Dog CLRN1 antibody; Canis familiaris CLRN1 antibody E2R999 93.0%
ARP59580 Dog CLRN1 antibody; Canis familiaris CLRN1 antibody E2R9A0 93.0%
ARP59580 Human CLRN1 antibody; Homo sapiens CLRN1 antibody P58418-4 100.0%
ARP59580 Human CLRN1 antibody; Homo sapiens CLRN1 antibody P58418 100.0%
ARP59580 Mouse CLRN1 antibody; Mus musculus CLRN1 antibody B7ZNE8 79.0%
ARP59580 Mouse CLRN1 antibody; Mus musculus CLRN1 antibody Q8BYX9 79.0%
ARP59580 Mouse CLRN1 antibody; Mus musculus CLRN1 antibody Q8K444 79.0%
ARP59580 Mouse CLRN1 antibody; Mus musculus CLRN1 antibody Q8K445-2 79.0%
ARP59580 Mouse CLRN1 antibody; Mus musculus CLRN1 antibody Q8K445 79.0%
ARP59580 Rat CLRN1 antibody; Rattus norvegicus CLRN1 antibody F1LPA1 79.0%
ARP59580 Rat CLRN1 antibody; Rattus norvegicus CLRN1 antibody Q8CJ58 79.0%
ARP59580 Rhesus macaque CLRN1 antibody; Macaca mulatta CLRN1 antibody F7EAD4 93.0%
ARP59580 Tasmanian devil CLRN1 antibody; Sarcophilus harrisii CLRN1 antibody G3X1B4 79.0%
ARP59580 White-tufted-ear marmoset CLRN1 antibody; Callithrix jacchus CLRN1 antibody F6X252 93.0%

Tissue & Cell Line Gene Expression Data