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Gene ID: 93978 | CLEC6A Antibody Resource


CLEC6A Antibody Resource
Gene Full Name: 
C-type lectin domain family 6, member A
Uniprot: 
Q6EIG7
Protein Name: 
C-type lectin domain family 6 member A
Nucleotide: 
NM_001007033
Alias: 
CLEC4N;CLECSF10;
Ensembl: 
ENSG00000205846
Location: 
12p13
HPRD: 
16722
NCBI Gene: 
93978
MIM: 
613579

Summary: 
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010]
Function: 
Binds high-mannose carbohydrates in a Ca2+-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway .
Subcellular location: 
Membrane; Single-pass type II membrane protein Probable.
PTM: 
Disulfide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP44533_P050 CLEC6A antibody - N-terminal region (ARP44533_P050) Polyclonal Human WB 50ug $289 Details
Polyclonal Antibody OAAB14280 CLEC6A antibody - C - terminal region (OAAB14280) Human WB 400ul $289 Details
Polyclonal Antibody OAAF04722 CLEC6A Antibody (OAAF04722) Polyclonal Human WB, ELISA 100 ug $229 Details

Show all CLEC6A antibodies


Product Images
CLEC6A antibody - N-terminal region (ARP44533_P050) in Human THP-1 cells using Western Blot

Sample Type: Human THP-1

CLEC6A antibody - C - terminal region (OAAB14280) in Human Placenta cells using Western Blot

Sample Type: Human Placenta

CLEC6A Antibody (OAAF04722) in K562 cells using Western Blot

Sample Type: K562


CLEC6A Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP44533 Bovine CLEC6A antibody; Bos taurus CLEC6A antibody Q3LUH2 85.0%
ARP44533 Bovine CLEC6A antibody; Bos taurus CLEC6A antibody F1MU21 83.0%
ARP44533 Chimpanzee CLEC6A antibody; Pan troglodytes CLEC6A antibody H2R7J1 93.0%
ARP44533 Human CLEC6A antibody; Homo sapiens CLEC6A antibody Q6EIG7-2 100.0%
ARP44533 Human CLEC6A antibody; Homo sapiens CLEC6A antibody Q6EIG7 100.0%
ARP44533 Rat CLEC6A antibody; Rattus norvegicus CLEC6A antibody D3ZWT9 90.0%
ARP44533 Rhesus macaque CLEC6A antibody; Macaca mulatta CLEC6A antibody F6S605 93.0%
ARP44533 Sumatran orangutan CLEC6A antibody; Pongo abelii CLEC6A antibody H2NGE5 100.0%
ARP44533 White-tufted-ear marmoset CLEC6A antibody; Callithrix jacchus CLEC6A antibody F7FKA2 85.0%
ARP44533 White-tufted-ear marmoset CLEC6A antibody; Callithrix jacchus CLEC6A antibody F7HZF1 85.0%

Tissue & Cell Line Gene Expression Data