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Gene ID: 10686 | CLDN16 Antibody Resource


CLDN16 Antibody Resource
Gene Full Name: 
claudin 16
Uniprot: 
Q9Y5I7
Protein Name: 
claudin-16
Nucleotide: 
NM_006580
Alias: 
HOMG3;PCLN1;
Ensembl: 
ENSG00000113946
Location: 
3q28
HPRD: 
04906
NCBI Gene: 
10686
MIM: 
603959

Summary: 
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]
Function: 
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
Subcellular location: 
Cell junction › tight junction. Cell membrane; Multi-pass membrane protein.
PTM: 
Disease: 
Hypomagnesemia 3 (HOMG3) [MIM:248250]: A progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP33632_T100 CLDN16 antibody - C-terminal region (ARP33632_T100) Polyclonal Bovine, Dog, Horse, Mouse, Pig, Rabbit WB 100ug $229 Details
Polyclonal Antibody ARP33632_P050 CLDN16 antibody - C-terminal region (ARP33632_P050) Polyclonal Bovine, Dog, Horse, Mouse, Pig, Rabbit WB 50ug $289 Details
Polyclonal Antibody OAAB00445 CLDN16 antibody - N-terminal region (OAAB00445) Human WB, IHC, ELISA 400ul $289 Details

Show all CLDN16 antibodies


Product Images
CLDN16 antibody - C-terminal region (ARP33632_P050) in Human kidney cells using Western Blot

Sample Type: Human kidney

CLDN16 antibody - C-terminal region (ARP33632_T100) in Human Fetal Kidney cells using Western Blot

Sample Type: Human Fetal Kidney

CLDN16 antibody - N-terminal region (OAAB00445) in human Kidney cells using Immunohistochemistry

Sample Type: human Kidney

CLDN16 antibody - N-terminal region (OAAB00445) in MDA-MB435 cells using Western Blot

Sample Type: MDA-MB435


CLDN16 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP33632 Bovine CLDN16 antibody; Bos taurus CLDN16 antibody Q9XT98 86.0%
ARP33632 Cat CLDN16 antibody; Felis catus CLDN16 antibody M3W054 93.0%
ARP33632 Chimpanzee CLDN16 antibody; Pan troglodytes CLDN16 antibody H2QNY8 100.0%
ARP33632 Dog CLDN16 antibody; Canis familiaris CLDN16 antibody E2RQW9 86.0%
ARP33632 Dog CLDN16 antibody; Canis familiaris CLDN16 antibody J9NVB8 86.0%
ARP33632 European domestic ferret CLDN16 antibody; Mustela putorius furo CLDN16 antibody M3XWH9 86.0%
ARP33632 Gray short-tailed opossum CLDN16 antibody; Monodelphis domestica CLDN16 antibody F7F3I0 79.0%
ARP33632 Horse CLDN16 antibody; Equus caballus CLDN16 antibody F6XTZ8 93.0%
ARP33632 Human CLDN16 antibody; Homo sapiens CLDN16 antibody Q9Y5I7 100.0%
ARP33632 Mouse CLDN16 antibody; Mus musculus CLDN16 antibody Q14BW2 86.0%
ARP33632 Mouse CLDN16 antibody; Mus musculus CLDN16 antibody Q925N4 86.0%
ARP33632 Pig CLDN16 antibody; Sus scrofa CLDN16 antibody C3VMK4 86.0%
ARP33632 Pig CLDN16 antibody; Sus scrofa CLDN16 antibody I3L5Z0 86.0%
ARP33632 Rabbit CLDN16 antibody; Oryctolagus cuniculus CLDN16 antibody G1T1C9 93.0%
ARP33632 Rat CLDN16 antibody; Rattus norvegicus CLDN16 antibody D3ZJ06 86.0%
ARP33632 Rat CLDN16 antibody; Rattus norvegicus CLDN16 antibody Q91Y55 86.0%
ARP33632 Rhesus macaque CLDN16 antibody; Macaca mulatta CLDN16 antibody F6ZYC3 85.0%
ARP33632 Rhesus macaque CLDN16 antibody; Macaca mulatta CLDN16 antibody F7FN74 85.0%
ARP33632 Small-eared galago CLDN16 antibody; Otolemur garnettii CLDN16 antibody H0WLQ6 79.0%
ARP33632 Sumatran orangutan CLDN16 antibody; Pongo abelii CLDN16 antibody H2PCC0 86.0%
ARP33632 Thirteen-lined ground squirrel CLDN16 antibody; Spermophilus tridecemlineatus CLDN16 antibody I3MC59 93.0%
ARP33632 White-tufted-ear marmoset CLDN16 antibody; Callithrix jacchus CLDN16 antibody F7I767 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas220332_at721_B_lymphoblasts5.6004.490Details
BioGPS Gene Atlas220332_atAdipocyte4.3504.490Details
BioGPS Gene Atlas220332_atAdrenalCortex4.6004.490Details
BioGPS Gene Atlas220332_atAdrenalgland3.7004.490Details
BioGPS Gene Atlas220332_atAmygdala4.7004.490Details
BioGPS Gene Atlas220332_atAppendix4.6004.490Details
BioGPS Gene Atlas220332_atAtrioventricularNode3.3504.490Details
BioGPS Gene Atlas220332_atBDCA4+_DentriticCells5.0504.490Details
BioGPS Gene Atlas220332_atBonemarrow4.3504.490Details
BioGPS Gene Atlas220332_atBronchialEpithelialCells4.4004.490Details
BioGPS Gene Atlas220332_atCD105+_Endothelial4.5004.490Details
BioGPS Gene Atlas220332_atCD14+_Monocytes4.7504.490Details
BioGPS Gene Atlas220332_atCD19+_BCells(neg._sel.)4.7504.490Details
BioGPS Gene Atlas220332_atCD33+_Myeloid5.7004.490Details
BioGPS Gene Atlas220332_atCD34+5.7004.490Details
BioGPS Gene Atlas220332_atCD4+_Tcells4.9004.490Details
BioGPS Gene Atlas220332_atCD56+_NKCells5.4004.490Details
BioGPS Gene Atlas220332_atCD71+_EarlyErythroid4.1004.490Details
BioGPS Gene Atlas220332_atCD8+_Tcells4.3004.490Details
BioGPS Gene Atlas220332_atCardiacMyocytes6.0504.490Details
BioGPS Gene Atlas220332_atCaudatenucleus3.9504.490Details
BioGPS Gene Atlas220332_atCerebellum3.5504.490Details
BioGPS Gene Atlas220332_atCerebellumPeduncles5.0004.490Details
BioGPS Gene Atlas220332_atCiliaryGanglion3.2504.490Details
BioGPS Gene Atlas220332_atCingulateCortex4.4504.490Details
BioGPS Gene Atlas220332_atColorectaladenocarcinoma4.4504.490Details
BioGPS Gene Atlas220332_atDorsalRootGanglion3.3504.490Details
BioGPS Gene Atlas220332_atFetalThyroid4.3004.490Details
BioGPS Gene Atlas220332_atFetalbrain4.4004.490Details
BioGPS Gene Atlas220332_atFetalliver3.9004.490Details
BioGPS Gene Atlas220332_atFetallung3.7004.490Details
BioGPS Gene Atlas220332_atGlobusPallidus3.2504.490Details
BioGPS Gene Atlas220332_atHeart6.0004.490Details
BioGPS Gene Atlas220332_atHypothalamus4.7504.490Details
BioGPS Gene Atlas220332_atKidney3.5004.490Details
BioGPS Gene Atlas220332_atLeukemia_chronicMyelogenousK-5624.0004.490Details
BioGPS Gene Atlas220332_atLeukemia_promyelocytic-HL-603.9004.490Details
BioGPS Gene Atlas220332_atLeukemialymphoblastic(MOLT-4)3.5504.490Details
BioGPS Gene Atlas220332_atLiver6.4004.490Details
BioGPS Gene Atlas220332_atLung4.8504.490Details
BioGPS Gene Atlas220332_atLymphnode3.8504.490Details
BioGPS Gene Atlas220332_atLymphoma_burkitts(Daudi)5.6004.490Details
BioGPS Gene Atlas220332_atLymphoma_burkitts(Raji)6.6004.490Details
BioGPS Gene Atlas220332_atMedullaOblongata4.0004.490Details
BioGPS Gene Atlas220332_atOccipitalLobe3.9504.490Details
BioGPS Gene Atlas220332_atOlfactoryBulb3.4504.490Details
BioGPS Gene Atlas220332_atOvary2.9504.490Details
BioGPS Gene Atlas220332_atPancreas3.6004.490Details
BioGPS Gene Atlas220332_atPancreaticIslet4.7504.490Details
BioGPS Gene Atlas220332_atParietalLobe4.6004.490Details
BioGPS Gene Atlas220332_atPituitary5.1504.490Details
BioGPS Gene Atlas220332_atPlacenta4.5504.490Details
BioGPS Gene Atlas220332_atPons4.2004.490Details
BioGPS Gene Atlas220332_atPrefrontalCortex5.4004.490Details
BioGPS Gene Atlas220332_atProstate5.2504.490Details
BioGPS Gene Atlas220332_atSalivarygland3.5004.490Details
BioGPS Gene Atlas220332_atSkeletalMuscle4.9004.490Details
BioGPS Gene Atlas220332_atSkin3.6504.490Details
BioGPS Gene Atlas220332_atSmoothMuscle5.0004.490Details
BioGPS Gene Atlas220332_atSpinalcord4.7004.490Details
BioGPS Gene Atlas220332_atSubthalamicNucleus4.0004.490Details
BioGPS Gene Atlas220332_atSuperiorCervicalGanglion5.2004.490Details
BioGPS Gene Atlas220332_atTemporalLobe4.0004.490Details
BioGPS Gene Atlas220332_atTestis3.8004.490Details
BioGPS Gene Atlas220332_atTestisGermCell3.7504.490Details
BioGPS Gene Atlas220332_atTestisIntersitial3.7504.490Details
BioGPS Gene Atlas220332_atTestisLeydigCell4.3504.490Details
BioGPS Gene Atlas220332_atTestisSeminiferousTubule3.7504.490Details
BioGPS Gene Atlas220332_atThalamus4.4504.490Details
BioGPS Gene Atlas220332_atThymus3.5504.490Details
BioGPS Gene Atlas220332_atThyroid5.6004.490Details
BioGPS Gene Atlas220332_atTongue4.3004.490Details
BioGPS Gene Atlas220332_atTonsil4.3004.490Details
BioGPS Gene Atlas220332_atTrachea3.7004.490Details
BioGPS Gene Atlas220332_atTrigeminalGanglion4.6504.490Details
BioGPS Gene Atlas220332_atUterus3.7004.490Details
BioGPS Gene Atlas220332_atUterusCorpus4.3504.490Details
BioGPS Gene Atlas220332_atWholeBlood4.8504.490Details
BioGPS Gene Atlas220332_atWholebrain3.7004.490Details
BioGPS Gene Atlas220332_atcolon4.4504.490Details
BioGPS Gene Atlas220332_atpineal_day5.4804.490Details
BioGPS Gene Atlas220332_atpineal_night5.4404.490Details
BioGPS Gene Atlas220332_atretina5.4004.490Details
BioGPS Gene Atlas220332_atsmall_intestine4.2504.490Details
BioGPS NCI60220332_at7864.59257.880Details
BioGPS NCI60220332_atA1724.39157.880Details
BioGPS NCI60220332_atA2044.46057.880Details
BioGPS NCI60220332_atA3614.54457.880Details
BioGPS NCI60220332_atA4984.50657.880Details
BioGPS NCI60220332_atA5494.55957.880Details
BioGPS NCI60220332_atACC34.79657.880Details
BioGPS NCI60220332_atACHN5391.26957.880Details
BioGPS NCI60220332_atALVA314.68757.880Details
BioGPS NCI60220332_atCAKI14.75057.880Details
BioGPS NCI60220332_atCCRT CEM4.85757.880Details
BioGPS NCI60220332_atCOLO2054.49857.880Details
BioGPS NCI60220332_atDLD14.46557.880Details
BioGPS NCI60220332_atDU1454.28957.880Details
BioGPS NCI60220332_atEKVX4.28957.880Details
BioGPS NCI60220332_atGM1335.00057.880Details
BioGPS NCI60220332_atGM16004.80457.880Details
BioGPS NCI60220332_atGM23134.62157.880Details
BioGPS NCI60220332_atGM23454.54357.880Details
BioGPS NCI60220332_atGM24935.24757.880Details
BioGPS NCI60220332_atGM975.15957.880Details
BioGPS NCI60220332_atHCC29984.16757.880Details
BioGPS NCI60220332_atHCT1164.48157.880Details
BioGPS NCI60220332_atHCT154.29257.880Details
BioGPS NCI60220332_atHEK 293 T-rex4.76357.880Details
BioGPS NCI60220332_atHEK 293T4.56057.880Details
BioGPS NCI60220332_atHEK2934.55157.880Details
BioGPS NCI60220332_atHELA4.17857.880Details
BioGPS NCI60220332_atHEPG24.48957.880Details
BioGPS NCI60220332_atHL604.52457.880Details
BioGPS NCI60220332_atHOP624.51357.880Details
BioGPS NCI60220332_atHOP924.33057.880Details
BioGPS NCI60220332_atHS578T4.43157.880Details
BioGPS NCI60220332_atHSG4.42557.880Details
BioGPS NCI60220332_atHT10804.43857.880Details
BioGPS NCI60220332_atHT295.00857.880Details
BioGPS NCI60220332_atIGROV1373.04057.880Details
BioGPS NCI60220332_atIOSE804.46057.880Details
BioGPS NCI60220332_atJURKAT4.51157.880Details
BioGPS NCI60220332_atK5624.91757.880Details
BioGPS NCI60220332_atKM124.78057.880Details
BioGPS NCI60220332_atLN184.35657.880Details
BioGPS NCI60220332_atLNCAP4.49857.880Details
BioGPS NCI60220332_atLOX IMVI4.51757.880Details
BioGPS NCI60220332_atM144.45857.880Details
BioGPS NCI60220332_atMALME 3M4.70057.880Details
BioGPS NCI60220332_atMCF74.33957.880Details
BioGPS NCI60220332_atMD MB2314.53457.880Details
BioGPS NCI60220332_atMDA MB4354.70057.880Details
BioGPS NCI60220332_atMOLT44.58657.880Details
BioGPS NCI60220332_atNCI 4604.59457.880Details
BioGPS NCI60220332_atNCI H2264.67057.880Details
BioGPS NCI60220332_atNCI H234.50557.880Details
BioGPS NCI60220332_atNCI H322M4.49057.880Details
BioGPS NCI60220332_atNCVADR RES8.74657.880Details
BioGPS NCI60220332_atOVCAR34.78157.880Details
BioGPS NCI60220332_atOVCAR44.48757.880Details
BioGPS NCI60220332_atOVCAR54.41457.880Details
BioGPS NCI60220332_atOVCAR84.18457.880Details
BioGPS NCI60220332_atPANC14.50357.880Details
BioGPS NCI60220332_atRL74.62457.880Details
BioGPS NCI60220332_atRPMI 82264.61557.880Details
BioGPS NCI60220332_atRS118464.86757.880Details
BioGPS NCI60220332_atRXF3934.46557.880Details
BioGPS NCI60220332_atSAOS24.54657.880Details
BioGPS NCI60220332_atSF2684.50857.880Details
BioGPS NCI60220332_atSF2954.42757.880Details
BioGPS NCI60220332_atSF5394.29857.880Details
BioGPS NCI60220332_atSHSYSY+RA4.32557.880Details
BioGPS NCI60220332_atSHSYSY-RA4.42457.880Details
BioGPS NCI60220332_atSKMEL24.48657.880Details
BioGPS NCI60220332_atSKMEL284.51857.880Details
BioGPS NCI60220332_atSKMEL54.37557.880Details
BioGPS NCI60220332_atSKOV34.60857.880Details
BioGPS NCI60220332_atSN12C4.46757.880Details
BioGPS NCI60220332_atSNB194.40257.880Details
BioGPS NCI60220332_atSNB754.46957.880Details
BioGPS NCI60220332_atSR4.54757.880Details
BioGPS NCI60220332_atSW6204.61657.880Details
BioGPS NCI60220332_atT244.56257.880Details
BioGPS NCI60220332_atT3M44.75457.880Details
BioGPS NCI60220332_atTK104.48457.880Details
BioGPS NCI60220332_atU1184.44157.880Details
BioGPS NCI60220332_atU1384.42857.880Details
BioGPS NCI60220332_atU20S4.52857.880Details
BioGPS NCI60220332_atU2514.47957.880Details
BioGPS NCI60220332_atU874.47257.880Details
BioGPS NCI60220332_atUACC2574.46357.880Details
BioGPS NCI60220332_atUACC624.55057.880Details
BioGPS NCI60220332_atUO314.48857.880Details
BioGPS NCI60220332_atZR75_14.58157.880Details
BioGPS NCI60220332_atastrocytes4.59857.880Details
BioGPS NCI60220332_athuh-74.80957.880Details