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Gene ID: 1154 | Cish Antibody Resource


Cish Antibody Resource
Gene Full Name: 
cytokine inducible SH2-containing protein
Uniprot: 
Q9NSE2
Protein Name: 
cytokine-inducible SH2-containing protein
Nucleotide: 
NM_145071
Alias: 
CIS;G18;SOCS;CIS-1;BACTS2;
Ensembl: 
ENSG00000114737
Location: 
3p21.3
HPRD: 
03897
NCBI Gene: 
1154
MIM: 
602441

Summary: 
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Function: 
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins .
Subcellular location: 
PTM: 
Ubl conjugation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP52798_P050 Cish antibody - N-terminal region (ARP52798_P050) Polyclonal Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody ARP52799_P050 CISH Antibody (ARP52799_P050) Polyclonal Bovine, Dog, Horse, Human, Mouse, Rabbit, Rat Not tested 50 ug $125 Details

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Product Images
Cish antibody - N-terminal region (ARP52798_P050) in Mouse Heart cells using Western Blot

Sample Type: Mouse Heart


Cish Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP52798 Bovine Cish antibody; Bos taurus Cish antibody Q2HJ53 100.0%
ARP52798 Bovine Cish antibody; Bos taurus Cish antibody J7H9A9 100.0%
ARP52799 Bovine Cish antibody; Bos taurus Cish antibody Q2HJ53 86.0%
ARP52799 Bovine Cish antibody; Bos taurus Cish antibody J7H9A9 86.0%
ARP52798 Cat Cish antibody; Felis catus Cish antibody M3WSP2 100.0%
ARP52799 Cat Cish antibody; Felis catus Cish antibody M3WSP2 93.0%
ARP52798 Chicken Cish antibody; Gallus gallus Cish antibody Q9PW70 93.0%
ARP52798 Chicken Cish antibody; Gallus gallus Cish antibody G1K2Y8 93.0%
ARP52798 Chimpanzee Cish antibody; Pan troglodytes Cish antibody H2QMP4 100.0%
ARP52799 Chimpanzee Cish antibody; Pan troglodytes Cish antibody H2QMP4 100.0%
ARP52798 Chimpanzee Cish antibody; Pan troglodytes Cish antibody H2RGD4 100.0%
ARP52799 Chimpanzee Cish antibody; Pan troglodytes Cish antibody H2RGD4 100.0%
ARP52798 Chinese softshell turtle Cish antibody; Pelodiscus sinensis Cish antibody K7GCT3 93.0%
ARP52798 Collared flycatcher Cish antibody; Ficedula albicollis Cish antibody U3K2P7 93.0%
ARP52798 Collared flycatcher Cish antibody; Ficedula albicollis Cish antibody U3K2P8 93.0%
ARP52798 Dog Cish antibody; Canis familiaris Cish antibody F1PSF4 100.0%
ARP52798 Dog Cish antibody; Canis familiaris Cish antibody J9P2S2 100.0%
ARP52799 Dog Cish antibody; Canis familiaris Cish antibody F1PSF4 93.0%
ARP52799 Dog Cish antibody; Canis familiaris Cish antibody J9P2S2 93.0%
ARP52798 Domestic duck Cish antibody; Anas platyrhynchos Cish antibody U3J9P5 93.0%
ARP52798 Duckbill platypus Cish antibody; Ornithorhynchus anatinus Cish antibody F6W0S0 93.0%
ARP52798 European domestic ferret Cish antibody; Mustela putorius furo Cish antibody M3YNG5 100.0%
ARP52799 European domestic ferret Cish antibody; Mustela putorius furo Cish antibody M3YNG5 93.0%
ARP52798 Giant panda Cish antibody; Ailuropoda melanoleuca Cish antibody G1LYG6 100.0%
ARP52799 Giant panda Cish antibody; Ailuropoda melanoleuca Cish antibody G1LYG6 100.0%
ARP52798 Giant panda Cish antibody; Ailuropoda melanoleuca Cish antibody G1LYH5 100.0%
ARP52799 Giant panda Cish antibody; Ailuropoda melanoleuca Cish antibody G1LYH5 100.0%
ARP52798 Gray short-tailed opossum Cish antibody; Monodelphis domestica Cish antibody F7BA11 79.0%
ARP52798 Green anole Cish antibody; Anolis carolinensis Cish antibody G1KG76 86.0%
ARP52798 Horse Cish antibody; Equus caballus Cish antibody F6XMN0 100.0%
ARP52799 Horse Cish antibody; Equus caballus Cish antibody F6XMN0 86.0%
ARP52798 Human Cish antibody; Homo sapiens Cish antibody Q9NSE2-2 100.0%
ARP52799 Human Cish antibody; Homo sapiens Cish antibody Q9NSE2-2 100.0%
ARP52798 Human Cish antibody; Homo sapiens Cish antibody Q9NSE2-3 100.0%
ARP52799 Human Cish antibody; Homo sapiens Cish antibody Q9NSE2-3 100.0%
ARP52798 Human Cish antibody; Homo sapiens Cish antibody Q9NSE2 100.0%
ARP52799 Human Cish antibody; Homo sapiens Cish antibody Q9NSE2 100.0%
ARP52798 Mouse Cish antibody; Mus musculus Cish antibody Q62225 100.0%
ARP52799 Mouse Cish antibody; Mus musculus Cish antibody Q62225 100.0%
ARP52798 Mouse Cish antibody; Mus musculus Cish antibody E9PYE4 100.0%
ARP52798 Northern white-cheeked gibbon Cish antibody; Nomascus leucogenys Cish antibody G1R5U7 100.0%
ARP52799 Northern white-cheeked gibbon Cish antibody; Nomascus leucogenys Cish antibody G1R5U7 100.0%
ARP52798 Rabbit Cish antibody; Oryctolagus cuniculus Cish antibody G1TQ50 100.0%
ARP52798 Rabbit Cish antibody; Oryctolagus cuniculus Cish antibody G1TSN7 100.0%
ARP52799 Rabbit Cish antibody; Oryctolagus cuniculus Cish antibody G1TQ50 93.0%
ARP52799 Rabbit Cish antibody; Oryctolagus cuniculus Cish antibody G1TSN7 93.0%
ARP52798 Rat Cish antibody; Rattus norvegicus Cish antibody B1WBX9 100.0%
ARP52799 Rat Cish antibody; Rattus norvegicus Cish antibody B1WBX9 100.0%
ARP52798 Rat Cish antibody; Rattus norvegicus Cish antibody O70512 100.0%
ARP52799 Rat Cish antibody; Rattus norvegicus Cish antibody O70512 100.0%
ARP52798 Rhesus macaque Cish antibody; Macaca mulatta Cish antibody F7BFK3 100.0%
ARP52799 Rhesus macaque Cish antibody; Macaca mulatta Cish antibody F7BFK3 100.0%
ARP52798 Small-eared galago Cish antibody; Otolemur garnettii Cish antibody H0XL05 100.0%
ARP52799 Small-eared galago Cish antibody; Otolemur garnettii Cish antibody H0XL05 93.0%
ARP52798 Sumatran orangutan Cish antibody; Pongo abelii Cish antibody H2PAM9 100.0%
ARP52799 Sumatran orangutan Cish antibody; Pongo abelii Cish antibody H2PAM9 100.0%
ARP52798 Tasmanian devil Cish antibody; Sarcophilus harrisii Cish antibody G5EA61 79.0%
ARP52798 Tasmanian devil Cish antibody; Sarcophilus harrisii Cish antibody G5EA62 79.0%
ARP52798 Thirteen-lined ground squirrel Cish antibody; Spermophilus tridecemlineatus Cish antibody I3N961 100.0%
ARP52799 Thirteen-lined ground squirrel Cish antibody; Spermophilus tridecemlineatus Cish antibody I3N961 93.0%
ARP52798 Western clawed frog Cish antibody; Xenopus tropicalis Cish antibody A9ULE1 79.0%
ARP52798 Western clawed frog Cish antibody; Xenopus tropicalis Cish antibody B7ZTW0 79.0%
ARP52798 Western clawed frog Cish antibody; Xenopus tropicalis Cish antibody F7C1F6 79.0%
ARP52798 White-tufted-ear marmoset Cish antibody; Callithrix jacchus Cish antibody F7GWT1 100.0%
ARP52799 White-tufted-ear marmoset Cish antibody; Callithrix jacchus Cish antibody F7GWT1 100.0%
ARP52798 White-tufted-ear marmoset Cish antibody; Callithrix jacchus Cish antibody F7GWT9 100.0%
ARP52799 White-tufted-ear marmoset Cish antibody; Callithrix jacchus Cish antibody F7GWT9 100.0%
ARP52798 Zebra finch Cish antibody; Taeniopygia guttata Cish antibody H0Z2R4 93.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas221223_x_at721_B_lymphoblasts5.5008.850Details
BioGPS Gene Atlas221223_x_atAdipocyte3.9008.850Details
BioGPS Gene Atlas221223_x_atAdrenalCortex4.1008.850Details
BioGPS Gene Atlas221223_x_atAdrenalgland3.3508.850Details
BioGPS Gene Atlas221223_x_atAmygdala4.3508.850Details
BioGPS Gene Atlas221223_x_atAppendix4.0508.850Details
BioGPS Gene Atlas221223_x_atAtrioventricularNode2.9508.850Details
BioGPS Gene Atlas221223_x_atBDCA4+_DentriticCells4.4508.850Details
BioGPS Gene Atlas221223_x_atBonemarrow6.6008.850Details
BioGPS Gene Atlas221223_x_atBronchialEpithelialCells3.9508.850Details
BioGPS Gene Atlas221223_x_atCD105+_Endothelial5.6008.850Details
BioGPS Gene Atlas221223_x_atCD14+_Monocytes4.4008.850Details
BioGPS Gene Atlas221223_x_atCD19+_BCells(neg._sel.)4.0508.850Details
BioGPS Gene Atlas221223_x_atCD33+_Myeloid5.1008.850Details
BioGPS Gene Atlas221223_x_atCD34+4.9508.850Details
BioGPS Gene Atlas221223_x_atCD4+_Tcells31.9508.850Details
BioGPS Gene Atlas221223_x_atCD56+_NKCells5.0008.850Details
BioGPS Gene Atlas221223_x_atCD71+_EarlyErythroid3.7508.850Details
BioGPS Gene Atlas221223_x_atCD8+_Tcells30.0508.850Details
BioGPS Gene Atlas221223_x_atCardiacMyocytes5.3508.850Details
BioGPS Gene Atlas221223_x_atCaudatenucleus3.5008.850Details
BioGPS Gene Atlas221223_x_atCerebellum3.3008.850Details
BioGPS Gene Atlas221223_x_atCerebellumPeduncles7.3508.850Details
BioGPS Gene Atlas221223_x_atCiliaryGanglion2.7508.850Details
BioGPS Gene Atlas221223_x_atCingulateCortex4.0508.850Details
BioGPS Gene Atlas221223_x_atColorectaladenocarcinoma4.5508.850Details
BioGPS Gene Atlas221223_x_atDorsalRootGanglion4.3008.850Details
BioGPS Gene Atlas221223_x_atFetalThyroid8.2508.850Details
BioGPS Gene Atlas221223_x_atFetalbrain4.5008.850Details
BioGPS Gene Atlas221223_x_atFetalliver4.2508.850Details
BioGPS Gene Atlas221223_x_atFetallung16.1008.850Details
BioGPS Gene Atlas221223_x_atGlobusPallidus2.8008.850Details
BioGPS Gene Atlas221223_x_atHeart18.2008.850Details
BioGPS Gene Atlas221223_x_atHypothalamus4.4508.850Details
BioGPS Gene Atlas221223_x_atKidney6.5508.850Details
BioGPS Gene Atlas221223_x_atLeukemia_chronicMyelogenousK-562115.1008.850Details
BioGPS Gene Atlas221223_x_atLeukemia_promyelocytic-HL-603.5508.850Details
BioGPS Gene Atlas221223_x_atLeukemialymphoblastic(MOLT-4)4.0508.850Details
BioGPS Gene Atlas221223_x_atLiver6.1508.850Details
BioGPS Gene Atlas221223_x_atLung90.6508.850Details
BioGPS Gene Atlas221223_x_atLymphnode3.9508.850Details
BioGPS Gene Atlas221223_x_atLymphoma_burkitts(Daudi)5.1008.850Details
BioGPS Gene Atlas221223_x_atLymphoma_burkitts(Raji)6.0508.850Details
BioGPS Gene Atlas221223_x_atMedullaOblongata3.6508.850Details
BioGPS Gene Atlas221223_x_atOccipitalLobe3.6508.850Details
BioGPS Gene Atlas221223_x_atOlfactoryBulb3.1008.850Details
BioGPS Gene Atlas221223_x_atOvary4.1008.850Details
BioGPS Gene Atlas221223_x_atPancreas3.3508.850Details
BioGPS Gene Atlas221223_x_atPancreaticIslet7.1508.850Details
BioGPS Gene Atlas221223_x_atParietalLobe4.2008.850Details
BioGPS Gene Atlas221223_x_atPituitary8.5008.850Details
BioGPS Gene Atlas221223_x_atPlacenta90.5008.850Details
BioGPS Gene Atlas221223_x_atPons4.5008.850Details
BioGPS Gene Atlas221223_x_atPrefrontalCortex4.9008.850Details
BioGPS Gene Atlas221223_x_atProstate5.7508.850Details
BioGPS Gene Atlas221223_x_atSalivarygland3.2008.850Details
BioGPS Gene Atlas221223_x_atSkeletalMuscle5.0008.850Details
BioGPS Gene Atlas221223_x_atSkin3.2508.850Details
BioGPS Gene Atlas221223_x_atSmoothMuscle4.5508.850Details
BioGPS Gene Atlas221223_x_atSpinalcord4.1508.850Details
BioGPS Gene Atlas221223_x_atSubthalamicNucleus3.5008.850Details
BioGPS Gene Atlas221223_x_atSuperiorCervicalGanglion7.5508.850Details
BioGPS Gene Atlas221223_x_atTemporalLobe3.6008.850Details
BioGPS Gene Atlas221223_x_atTestis4.4508.850Details
BioGPS Gene Atlas221223_x_atTestisGermCell3.5008.850Details
BioGPS Gene Atlas221223_x_atTestisIntersitial3.9008.850Details
BioGPS Gene Atlas221223_x_atTestisLeydigCell3.9508.850Details
BioGPS Gene Atlas221223_x_atTestisSeminiferousTubule3.5508.850Details
BioGPS Gene Atlas221223_x_atThalamus3.9008.850Details
BioGPS Gene Atlas221223_x_atThymus4.8508.850Details
BioGPS Gene Atlas221223_x_atThyroid11.7008.850Details
BioGPS Gene Atlas221223_x_atTongue5.3508.850Details
BioGPS Gene Atlas221223_x_atTonsil4.3508.850Details
BioGPS Gene Atlas221223_x_atTrachea3.6008.850Details
BioGPS Gene Atlas221223_x_atTrigeminalGanglion3.9008.850Details
BioGPS Gene Atlas221223_x_atUterus3.7508.850Details
BioGPS Gene Atlas221223_x_atUterusCorpus6.7008.850Details
BioGPS Gene Atlas221223_x_atWholeBlood15.1508.850Details
BioGPS Gene Atlas221223_x_atWholebrain4.0508.850Details
BioGPS Gene Atlas221223_x_atcolon3.9008.850Details
BioGPS Gene Atlas221223_x_atpineal_day4.7408.850Details
BioGPS Gene Atlas221223_x_atpineal_night4.7608.850Details
BioGPS Gene Atlas221223_x_atretina4.7258.850Details
BioGPS Gene Atlas221223_x_atsmall_intestine3.7508.850Details
BioGPS NCI60221223_x_at7864.0986.570Details
BioGPS NCI60221223_x_atA1723.9976.570Details
BioGPS NCI60221223_x_atA2043.9876.570Details
BioGPS NCI60221223_x_atA3614.0626.570Details
BioGPS NCI60221223_x_atA4984.0476.570Details
BioGPS NCI60221223_x_atA5494.0396.570Details
BioGPS NCI60221223_x_atACC34.2006.570Details
BioGPS NCI60221223_x_atACHN3.9466.570Details
BioGPS NCI60221223_x_atALVA314.0956.570Details
BioGPS NCI60221223_x_atCAKI14.1126.570Details
BioGPS NCI60221223_x_atCCRT CEM4.3106.570Details
BioGPS NCI60221223_x_atCOLO2054.0136.570Details
BioGPS NCI60221223_x_atDLD13.9986.570Details
BioGPS NCI60221223_x_atDU1453.9146.570Details
BioGPS NCI60221223_x_atEKVX3.9596.570Details
BioGPS NCI60221223_x_atGM1334.0856.570Details
BioGPS NCI60221223_x_atGM16004.1186.570Details
BioGPS NCI60221223_x_atGM23134.0776.570Details
BioGPS NCI60221223_x_atGM23454.0596.570Details
BioGPS NCI60221223_x_atGM24934.1376.570Details
BioGPS NCI60221223_x_atGM974.2566.570Details
BioGPS NCI60221223_x_atHCC29983.8946.570Details
BioGPS NCI60221223_x_atHCT1166.4316.570Details
BioGPS NCI60221223_x_atHCT153.9516.570Details
BioGPS NCI60221223_x_atHEK 293 T-rex4.8606.570Details
BioGPS NCI60221223_x_atHEK 293T4.0746.570Details
BioGPS NCI60221223_x_atHEK2936.1916.570Details
BioGPS NCI60221223_x_atHELA3.9096.570Details
BioGPS NCI60221223_x_atHEPG24.0266.570Details
BioGPS NCI60221223_x_atHL604.0516.570Details
BioGPS NCI60221223_x_atHOP624.0486.570Details
BioGPS NCI60221223_x_atHOP923.9326.570Details
BioGPS NCI60221223_x_atHS578T4.0136.570Details
BioGPS NCI60221223_x_atHSG3.9656.570Details
BioGPS NCI60221223_x_atHT10803.9806.570Details
BioGPS NCI60221223_x_atHT294.2146.570Details
BioGPS NCI60221223_x_atIGROV14.0036.570Details
BioGPS NCI60221223_x_atIOSE804.0426.570Details
BioGPS NCI60221223_x_atJURKAT4.0436.570Details
BioGPS NCI60221223_x_atK562254.5376.570Details
BioGPS NCI60221223_x_atKM124.1426.570Details
BioGPS NCI60221223_x_atLN183.9746.570Details
BioGPS NCI60221223_x_atLNCAP4.8686.570Details
BioGPS NCI60221223_x_atLOX IMVI4.0296.570Details
BioGPS NCI60221223_x_atM144.0006.570Details
BioGPS NCI60221223_x_atMALME 3M4.1946.570Details
BioGPS NCI60221223_x_atMCF74.0046.570Details
BioGPS NCI60221223_x_atMD MB2314.0586.570Details
BioGPS NCI60221223_x_atMDA MB4354.1886.570Details
BioGPS NCI60221223_x_atMOLT44.1086.570Details
BioGPS NCI60221223_x_atNCI 4604.0886.570Details
BioGPS NCI60221223_x_atNCI H2264.0746.570Details
BioGPS NCI60221223_x_atNCI H234.0246.570Details
BioGPS NCI60221223_x_atNCI H322M4.0076.570Details
BioGPS NCI60221223_x_atNCVADR RES3.8836.570Details
BioGPS NCI60221223_x_atOVCAR34.1636.570Details
BioGPS NCI60221223_x_atOVCAR44.1866.570Details
BioGPS NCI60221223_x_atOVCAR53.9496.570Details
BioGPS NCI60221223_x_atOVCAR83.9726.570Details
BioGPS NCI60221223_x_atPANC14.0416.570Details
BioGPS NCI60221223_x_atRL74.0846.570Details
BioGPS NCI60221223_x_atRPMI 82264.0756.570Details
BioGPS NCI60221223_x_atRS118464.1076.570Details
BioGPS NCI60221223_x_atRXF3934.0186.570Details
BioGPS NCI60221223_x_atSAOS24.0716.570Details
BioGPS NCI60221223_x_atSF2684.0126.570Details
BioGPS NCI60221223_x_atSF2953.9856.570Details
BioGPS NCI60221223_x_atSF5393.8936.570Details
BioGPS NCI60221223_x_atSHSYSY+RA3.9936.570Details
BioGPS NCI60221223_x_atSHSYSY-RA4.0206.570Details
BioGPS NCI60221223_x_atSKMEL23.9936.570Details
BioGPS NCI60221223_x_atSKMEL284.0336.570Details
BioGPS NCI60221223_x_atSKMEL53.9066.570Details
BioGPS NCI60221223_x_atSKOV34.1876.570Details
BioGPS NCI60221223_x_atSN12C4.0446.570Details
BioGPS NCI60221223_x_atSNB193.8626.570Details
BioGPS NCI60221223_x_atSNB754.0266.570Details
BioGPS NCI60221223_x_atSR4.0866.570Details
BioGPS NCI60221223_x_atSW6204.0346.570Details
BioGPS NCI60221223_x_atT244.0726.570Details
BioGPS NCI60221223_x_atT3M44.6926.570Details
BioGPS NCI60221223_x_atTK104.0146.570Details
BioGPS NCI60221223_x_atU1184.0136.570Details
BioGPS NCI60221223_x_atU1383.9806.570Details
BioGPS NCI60221223_x_atU20S4.7806.570Details
BioGPS NCI60221223_x_atU2514.0026.570Details
BioGPS NCI60221223_x_atU873.9856.570Details
BioGPS NCI60221223_x_atUACC2573.9916.570Details
BioGPS NCI60221223_x_atUACC624.0696.570Details
BioGPS NCI60221223_x_atUO313.9616.570Details
BioGPS NCI60221223_x_atZR75_112.6476.570Details
BioGPS NCI60221223_x_atastrocytes4.5506.570Details
BioGPS NCI60221223_x_athuh-74.1326.570Details