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Gene ID: 493856 | CISD2 Antibody Resource


CISD2 Antibody Resource
Gene Full Name: 
CDGSH iron sulfur domain 2
Uniprot: 
Q8N5K1
Protein Name: 
CDGSH iron-sulfur domain-containing protein 2
Nucleotide: 
XM_005263040
Alias: 
ERIS;WFS2;ZCD2;NAF-1;Miner1;
Ensembl: 
Location: 
4q24
HPRD: 
17413
NCBI Gene: 
493856
MIM: 
611507

Summary: 
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Function: 
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Subcellular location: 
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note: According to , it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
PTM: 
Disease: 
Wolfram syndrome 2 (WFS2) [MIM:604928]: A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal ulceration. Diabetes insipidus may be absent. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP44552_P050 CISD2 antibody - N-terminal region (ARP44552_P050) Polyclonal Bovine, Human, Mouse, Rabbit, Rat, Zebrafish WB 50ug $289 Details
DNA/cDNA/RNA ANA10516 CISD2 (Human) cDNA (1ug) 1ug $189 Details
DNA/cDNA/RNA ANA10517 CISD2 (Human) cDNA (1ug) 1ug $189 Details
Protein Lysate APL10516 CISD2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Protein Lysate APL10517 CISD2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
DNA/cDNA/RNA ANA10244 CISD2 (Human) cDNA (1ug) 1ug $189 Details
DNA/cDNA/RNA ANA10245 CISD2 (Human) cDNA (1ug) 1ug $189 Details
Protein Lysate APL10244 CISD2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Protein Lysate APL10245 CISD2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details

Show all CISD2 antibodies


Product Images
CISD2 antibody - N-terminal region (ARP44552_P050) in Transfected 293T cells using Western Blot

Sample Type: Transfected 293T


CISD2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP65647 Caligus rogercresseyi CISD2 antibody C1BQA3 86.0%
ARP44552 American bullfrog CISD2 antibody; Lithobates catesbeiana CISD2 antibody C1C524 86.0%
ARP65647 American bullfrog CISD2 antibody; Lithobates catesbeiana CISD2 antibody C1C524 79.0%
ARP44552 Bovine CISD2 antibody; Bos taurus CISD2 antibody Q05B71 100.0%
ARP65647 Bovine CISD2 antibody; Bos taurus CISD2 antibody Q05B71 79.0%
ARP44552 Cat CISD2 antibody; Felis catus CISD2 antibody M3X8M2 100.0%
ARP65647 Cat CISD2 antibody; Felis catus CISD2 antibody M3X8M2 79.0%
ARP44552 Chicken CISD2 antibody; Gallus gallus CISD2 antibody R4GLS1 100.0%
ARP65647 Chicken CISD2 antibody; Gallus gallus CISD2 antibody R4GLS1 79.0%
ARP44552 Chimpanzee CISD2 antibody; Pan troglodytes CISD2 antibody H2QPZ0 100.0%
ARP44552 Chimpanzee CISD2 antibody; Pan troglodytes CISD2 antibody K6ZCB2 100.0%
ARP65647 Chimpanzee CISD2 antibody; Pan troglodytes CISD2 antibody H2QPZ0 79.0%
ARP65647 Chimpanzee CISD2 antibody; Pan troglodytes CISD2 antibody H2RF39 79.0%
ARP65647 Chimpanzee CISD2 antibody; Pan troglodytes CISD2 antibody K6ZCB2 79.0%
ARP44552 Chinese softshell turtle CISD2 antibody; Pelodiscus sinensis CISD2 antibody K7FIY0 86.0%
ARP65647 Chinese softshell turtle CISD2 antibody; Pelodiscus sinensis CISD2 antibody K7FIY0 79.0%
ARP65647 Chinese softshell turtle CISD2 antibody; Pelodiscus sinensis CISD2 antibody K7FIY6 79.0%
ARP65647 Chinese softshell turtle CISD2 antibody; Pelodiscus sinensis CISD2 antibody K7FIZ5 79.0%
ARP65647 Collared flycatcher CISD2 antibody; Ficedula albicollis CISD2 antibody U3K0G9 79.0%
ARP44552 Dog CISD2 antibody; Canis familiaris CISD2 antibody E2R702 100.0%
ARP65647 Dog CISD2 antibody; Canis familiaris CISD2 antibody E2R702 79.0%
ARP65647 Domestic duck CISD2 antibody; Anas platyrhynchos CISD2 antibody U3HYH7 79.0%
ARP65647 Duckbill platypus CISD2 antibody; Ornithorhynchus anatinus CISD2 antibody F7FB50 79.0%
ARP44552 European domestic ferret CISD2 antibody; Mustela putorius furo CISD2 antibody M3YD83 100.0%
ARP65647 European domestic ferret CISD2 antibody; Mustela putorius furo CISD2 antibody M3YD83 79.0%
ARP65647 Giant panda CISD2 antibody; Ailuropoda melanoleuca CISD2 antibody G1LQX4 79.0%
ARP44552 Gray short-tailed opossum CISD2 antibody; Monodelphis domestica CISD2 antibody F7E5W3 100.0%
ARP65647 Gray short-tailed opossum CISD2 antibody; Monodelphis domestica CISD2 antibody F7E5W3 79.0%
ARP65647 Horse CISD2 antibody; Equus caballus CISD2 antibody F6W079 79.0%
ARP44552 Human CISD2 antibody; Homo sapiens CISD2 antibody I3L1N9 100.0%
ARP44552 Human CISD2 antibody; Homo sapiens CISD2 antibody Q8N5K1 100.0%
ARP65647 Human CISD2 antibody; Homo sapiens CISD2 antibody Q8N5K1 79.0%
ARP65647 Human CISD2 antibody; Homo sapiens CISD2 antibody D6RCF4 79.0%
ARP44552 Mouse CISD2 antibody; Mus musculus CISD2 antibody Q9CQB5 100.0%
ARP44552 Mouse CISD2 antibody; Mus musculus CISD2 antibody D3Z3X4 100.0%
ARP65647 Mouse CISD2 antibody; Mus musculus CISD2 antibody Q9CQB5 79.0%
ARP44552 Northern white-cheeked gibbon CISD2 antibody; Nomascus leucogenys CISD2 antibody M3ZC24 93.0%
ARP65647 Northern white-cheeked gibbon CISD2 antibody; Nomascus leucogenys CISD2 antibody M3ZC24 79.0%
ARP44552 Pig CISD2 antibody; Sus scrofa CISD2 antibody F1S108 100.0%
ARP65647 Pig CISD2 antibody; Sus scrofa CISD2 antibody F1S108 79.0%
ARP44552 Rabbit CISD2 antibody; Oryctolagus cuniculus CISD2 antibody G1T6E9 100.0%
ARP65647 Rabbit CISD2 antibody; Oryctolagus cuniculus CISD2 antibody G1T6E9 79.0%
ARP44552 Rat CISD2 antibody; Rattus norvegicus CISD2 antibody D4AAE9 100.0%
ARP65647 Rat CISD2 antibody; Rattus norvegicus CISD2 antibody D4AAE9 79.0%
ARP65647 salmon louse CISD2 antibody; Lepeophtheirus salmonis CISD2 antibody D3PHA4 86.0%
ARP44552 Small-eared galago CISD2 antibody; Otolemur garnettii CISD2 antibody H0X7W2 100.0%
ARP65647 Small-eared galago CISD2 antibody; Otolemur garnettii CISD2 antibody H0X7W2 79.0%
ARP44552 Sumatran orangutan CISD2 antibody; Pongo abelii CISD2 antibody H2PE08 100.0%
ARP65647 Sumatran orangutan CISD2 antibody; Pongo abelii CISD2 antibody H2PE08 79.0%
ARP44552 Tasmanian devil CISD2 antibody; Sarcophilus harrisii CISD2 antibody G3VGL3 100.0%
ARP65647 Tasmanian devil CISD2 antibody; Sarcophilus harrisii CISD2 antibody G3VGL3 79.0%
ARP44552 Thirteen-lined ground squirrel CISD2 antibody; Spermophilus tridecemlineatus CISD2 antibody I3LYI5 100.0%
ARP65647 Thirteen-lined ground squirrel CISD2 antibody; Spermophilus tridecemlineatus CISD2 antibody I3LYI5 79.0%
ARP44552 Western clawed frog CISD2 antibody; Xenopus tropicalis CISD2 antibody F6TSD5 86.0%
ARP44552 Western clawed frog CISD2 antibody; Xenopus tropicalis CISD2 antibody Q5I027 86.0%
ARP65647 Western clawed frog CISD2 antibody; Xenopus tropicalis CISD2 antibody Q5I027 79.0%
ARP44552 White-tufted-ear marmoset CISD2 antibody; Callithrix jacchus CISD2 antibody F6Z4H8 100.0%
ARP65647 White-tufted-ear marmoset CISD2 antibody; Callithrix jacchus CISD2 antibody F6Z4H8 79.0%
ARP44552 Zebra finch CISD2 antibody; Taeniopygia guttata CISD2 antibody H0YZS9 100.0%
ARP65647 Zebra finch CISD2 antibody; Taeniopygia guttata CISD2 antibody H0YZS9 79.0%
ARP44552 Zebrafish CISD2 antibody; Danio rerio CISD2 antibody Q7T326 82.0%

Tissue & Cell Line Gene Expression Data