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Gene ID: 84916 | CIRH1A Antibody Resource


CIRH1A Antibody Resource
Gene Full Name: 
cirrhosis, autosomal recessive 1A (cirhin)
Uniprot: 
Q969X6
Protein Name: 
cirhin
Nucleotide: 
NM_032830
Alias: 
NAIC;UTP4;CIRHIN;TEX292;
Ensembl: 
ENSG00000141076
Location: 
16q22.1
HPRD: 
08468
NCBI Gene: 
84916
MIM: 
607456

Summary: 
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. [provided by RefSeq, Jul 2008]
Function: 
May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV. Ribosome biogenesis factor involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.
Subcellular location: 
Nucleus › nucleolus .
PTM: 
Disease: 
North American Indian childhood cirrhosis (NAIC) [MIM:604901]: Severe autosomal recessive intrahepatic cholestasis, originally described in Ojibway-Cree children from northwestern Quebec. NAIC typically presents with transient neonatal jaundice, in a child who is otherwise healthy, and progresses to biliary cirrhosis and portal hypertension. Biochemical and histopathological features suggest involvement of the bile ducts rather than of the bile canaliculi. They include elevated gamma glutamyltransferase and alkaline phosphatase levels, and, typically, marked fibrosis around bile ducts. Clinically, NAIC is distinct from other nonsyndromic familial cholestases because of its marked cholangiopathic features and severe degree of fibrosis on liver histology. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB06552 CIRH1A antibody - N-terminal region (OAAB06552) Human WB, IHC 400ul $289 Details
Polyclonal Antibody ARP60683_P050 CIRH1A Antibody (ARP60683_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP60682_P050 CIRH1A Antibody - middle region (ARP60682_P050) Human WB 50ug $289 Details

Show all CIRH1A antibodies


Product Images
CIRH1A Antibody - middle region (ARP60682_P050) in Human 721_B cells using Western Blot

Sample Type: Human 721_B

CIRH1A antibody - N-terminal region (OAAB06552) in brain cells using Immunohistochemistry

Sample Type: brain

CIRH1A antibody - N-terminal region (OAAB06552) in Neuro-2a cells using Western Blot

Sample Type: Neuro-2a


CIRH1A Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60682 African elephant CIRH1A antibody; Loxodonta africana CIRH1A antibody G3SLG7 86.0%
ARP60683 African elephant CIRH1A antibody; Loxodonta africana CIRH1A antibody G3SLG7 86.0%
ARP60683 Bovine CIRH1A antibody; Bos taurus CIRH1A antibody E1BC40 100.0%
ARP60682 Bovine CIRH1A antibody; Bos taurus CIRH1A antibody E1BC40 93.0%
ARP60682 Cat CIRH1A antibody; Felis catus CIRH1A antibody M3WF43 100.0%
ARP60683 Cat CIRH1A antibody; Felis catus CIRH1A antibody M3WF43 100.0%
ARP60682 Chimpanzee CIRH1A antibody; Pan troglodytes CIRH1A antibody H2QBE8 100.0%
ARP60683 Chimpanzee CIRH1A antibody; Pan troglodytes CIRH1A antibody H2QBE8 100.0%
ARP60682 Dog CIRH1A antibody; Canis familiaris CIRH1A antibody E2RPQ7 100.0%
ARP60683 Dog CIRH1A antibody; Canis familiaris CIRH1A antibody E2RPQ7 100.0%
ARP60682 European domestic ferret CIRH1A antibody; Mustela putorius furo CIRH1A antibody M3Y740 100.0%
ARP60683 European domestic ferret CIRH1A antibody; Mustela putorius furo CIRH1A antibody M3Y740 100.0%
ARP60682 Giant panda CIRH1A antibody; Ailuropoda melanoleuca CIRH1A antibody D2HLI8 100.0%
ARP60683 Giant panda CIRH1A antibody; Ailuropoda melanoleuca CIRH1A antibody D2HLI8 93.0%
ARP60683 Gray short-tailed opossum CIRH1A antibody; Monodelphis domestica CIRH1A antibody F6VXF1 79.0%
ARP60682 Horse CIRH1A antibody; Equus caballus CIRH1A antibody F6T6U5 100.0%
ARP60683 Horse CIRH1A antibody; Equus caballus CIRH1A antibody F6T6U5 100.0%
ARP60682 Human CIRH1A antibody; Homo sapiens CIRH1A antibody H3BSH7 100.0%
ARP60683 Human CIRH1A antibody; Homo sapiens CIRH1A antibody H3BSH7 100.0%
ARP60682 Human CIRH1A antibody; Homo sapiens CIRH1A antibody Q969X6-2 100.0%
ARP60682 Human CIRH1A antibody; Homo sapiens CIRH1A antibody Q969X6-3 100.0%
ARP60683 Human CIRH1A antibody; Homo sapiens CIRH1A antibody Q969X6-3 100.0%
ARP60682 Human CIRH1A antibody; Homo sapiens CIRH1A antibody Q969X6 100.0%
ARP60683 Human CIRH1A antibody; Homo sapiens CIRH1A antibody Q969X6 100.0%
ARP60683 Human CIRH1A antibody; Homo sapiens CIRH1A antibody H3BRM8 100.0%
ARP60682 Mouse CIRH1A antibody; Mus musculus CIRH1A antibody Q3UJY3 100.0%
ARP60683 Mouse CIRH1A antibody; Mus musculus CIRH1A antibody Q3UJY3 100.0%
ARP60682 Mouse CIRH1A antibody; Mus musculus CIRH1A antibody Q8R2N2 100.0%
ARP60683 Mouse CIRH1A antibody; Mus musculus CIRH1A antibody Q8R2N2 100.0%
ARP60682 Northern white-cheeked gibbon CIRH1A antibody; Nomascus leucogenys CIRH1A antibody G1R078 100.0%
ARP60683 Northern white-cheeked gibbon CIRH1A antibody; Nomascus leucogenys CIRH1A antibody G1R078 100.0%
ARP60683 Pig CIRH1A antibody; Sus scrofa CIRH1A antibody I3LIQ3 100.0%
ARP60683 Rabbit CIRH1A antibody; Oryctolagus cuniculus CIRH1A antibody G1SPJ7 100.0%
ARP60682 Rabbit CIRH1A antibody; Oryctolagus cuniculus CIRH1A antibody G1SPJ7 79.0%
ARP60682 Rat CIRH1A antibody; Rattus norvegicus CIRH1A antibody Q5I0C9 100.0%
ARP60683 Rat CIRH1A antibody; Rattus norvegicus CIRH1A antibody Q5I0C9 100.0%
ARP60682 Rhesus macaque CIRH1A antibody; Macaca mulatta CIRH1A antibody H9EV88 100.0%
ARP60683 Rhesus macaque CIRH1A antibody; Macaca mulatta CIRH1A antibody H9EV88 100.0%
ARP60682 Small-eared galago CIRH1A antibody; Otolemur garnettii CIRH1A antibody H0XF86 100.0%
ARP60683 Small-eared galago CIRH1A antibody; Otolemur garnettii CIRH1A antibody H0XF86 100.0%
ARP60683 Sumatran orangutan CIRH1A antibody; Pongo abelii CIRH1A antibody H2NRC0 100.0%
ARP60682 Sumatran orangutan CIRH1A antibody; Pongo abelii CIRH1A antibody H2NRC0 93.0%
ARP60683 Tasmanian devil CIRH1A antibody; Sarcophilus harrisii CIRH1A antibody G3WHE4 79.0%
ARP60682 Thirteen-lined ground squirrel CIRH1A antibody; Spermophilus tridecemlineatus CIRH1A antibody I3MQK3 100.0%
ARP60683 Thirteen-lined ground squirrel CIRH1A antibody; Spermophilus tridecemlineatus CIRH1A antibody I3MQK3 100.0%
ARP60682 White-tufted-ear marmoset CIRH1A antibody; Callithrix jacchus CIRH1A antibody F6V3S3 93.0%
ARP60683 White-tufted-ear marmoset CIRH1A antibody; Callithrix jacchus CIRH1A antibody F6V3S3 93.0%
ARP60682 White-tufted-ear marmoset CIRH1A antibody; Callithrix jacchus CIRH1A antibody F6VNN1 93.0%

Tissue & Cell Line Gene Expression Data