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Gene ID: 8483 | CILP Antibody Resource


CILP Antibody Resource
Gene Full Name: 
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Uniprot: 
O75339
Protein Name: 
cartilage intermediate layer protein 1
Nucleotide: 
NM_003613
Alias: 
CILP-1;HsT18872;
Ensembl: 
ENSG00000138615
Location: 
15q22
HPRD: 
11942
NCBI Gene: 
8483
MIM: 
603489

Summary: 
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
Function: 
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Subcellular location: 
Secreted › extracellular space › extracellular matrix .
PTM: 
Cleavage on pair of basic residues;
Disease: 
Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to intervertebral disk disease, is conferred by variant p.Ile395Thr ().
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAEB01146 CILP Antibody (OAEB01146) Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Zebrafish WB 0.1mg $289 Details
Polyclonal Antibody ARP64683_P050 CILP antibody - C-terminal region (ARP64683_P050) Human WB 50ug $289 Details

Show all CILP antibodies


Product Images
CILP antibody - C-terminal region (ARP64683_P050) in Human 721_B cells using Western Blot

Sample Type: Human 721_B

CILP Antibody (OAEB01146) in Ratpinal Cord cells using Western Blot

Sample Type: Ratpinal Cord


CILP Protocols
Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP64683 African elephant CILP antibody; Loxodonta africana CILP antibody G3SX23 93.0%
ARP64683 Cat CILP antibody; Felis catus CILP antibody M3WF53 93.0%
ARP64683 Chimpanzee CILP antibody; Pan troglodytes CILP antibody H2Q9M0 100.0%
ARP64683 Dog CILP antibody; Canis familiaris CILP antibody E2QSQ9 93.0%
ARP64683 Dog CILP antibody; Canis familiaris CILP antibody F6V790 93.0%
ARP64683 European domestic ferret CILP antibody; Mustela putorius furo CILP antibody M3XN49 93.0%
ARP64683 Giant panda CILP antibody; Ailuropoda melanoleuca CILP antibody G1L7Y1 100.0%
ARP64683 Gray short-tailed opossum CILP antibody; Monodelphis domestica CILP antibody F6SSK8 93.0%
ARP64683 Horse CILP antibody; Equus caballus CILP antibody F7C2J3 93.0%
ARP64683 Human CILP antibody; Homo sapiens CILP antibody O75339 100.0%
ARP64683 Mouse CILP antibody; Mus musculus CILP antibody Q66K08 93.0%
ARP64683 Pig CILP antibody; Sus scrofa CILP antibody F1SJL4 93.0%
ARP64683 Pig CILP antibody; Sus scrofa CILP antibody O19112 93.0%
ARP64683 Rabbit CILP antibody; Oryctolagus cuniculus CILP antibody G1SSS1 93.0%
ARP64683 Rat CILP antibody; Rattus norvegicus CILP antibody D3ZGB8 93.0%
ARP64683 Rhesus macaque CILP antibody; Macaca mulatta CILP antibody F6YJ87 100.0%
ARP64683 Rhesus macaque CILP antibody; Macaca mulatta CILP antibody I2CUV8 100.0%
ARP64683 Small-eared galago CILP antibody; Otolemur garnettii CILP antibody H0XUV0 100.0%
ARP64683 Sumatran orangutan CILP antibody; Pongo abelii CILP antibody H2NNI4 100.0%
ARP64683 Tasmanian devil CILP antibody; Sarcophilus harrisii CILP antibody G3WDT9 100.0%
ARP64683 Thirteen-lined ground squirrel CILP antibody; Spermophilus tridecemlineatus CILP antibody I3N356 100.0%
ARP64683 White-tufted-ear marmoset CILP antibody; Callithrix jacchus CILP antibody U3D515 100.0%
ARP64683 White-tufted-ear marmoset CILP antibody; Callithrix jacchus CILP antibody U3ECW2 100.0%
ARP66767 White-tufted-ear marmoset CILP antibody; Callithrix jacchus CILP antibody U3D515 79.0%
ARP66767 White-tufted-ear marmoset CILP antibody; Callithrix jacchus CILP antibody U3ECW2 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas206227_at721_B_lymphoblasts4.60011.270Details
BioGPS Gene Atlas206227_atAdipocyte371.80011.270Details
BioGPS Gene Atlas206227_atAdrenalCortex3.80011.270Details
BioGPS Gene Atlas206227_atAdrenalgland3.10011.270Details
BioGPS Gene Atlas206227_atAmygdala4.15011.270Details
BioGPS Gene Atlas206227_atAppendix26.50011.270Details
BioGPS Gene Atlas206227_atAtrioventricularNode2.85011.270Details
BioGPS Gene Atlas206227_atBDCA4+_DentriticCells4.05011.270Details
BioGPS Gene Atlas206227_atBonemarrow3.65011.270Details
BioGPS Gene Atlas206227_atBronchialEpithelialCells3.65011.270Details
BioGPS Gene Atlas206227_atCD105+_Endothelial3.80011.270Details
BioGPS Gene Atlas206227_atCD14+_Monocytes3.95011.270Details
BioGPS Gene Atlas206227_atCD19+_BCells(neg._sel.)3.95011.270Details
BioGPS Gene Atlas206227_atCD33+_Myeloid4.75011.270Details
BioGPS Gene Atlas206227_atCD34+4.75011.270Details
BioGPS Gene Atlas206227_atCD4+_Tcells4.05011.270Details
BioGPS Gene Atlas206227_atCD56+_NKCells4.40011.270Details
BioGPS Gene Atlas206227_atCD71+_EarlyErythroid3.45011.270Details
BioGPS Gene Atlas206227_atCD8+_Tcells3.60011.270Details
BioGPS Gene Atlas206227_atCardiacMyocytes4.60011.270Details
BioGPS Gene Atlas206227_atCaudatenucleus3.35011.270Details
BioGPS Gene Atlas206227_atCerebellum3.00011.270Details
BioGPS Gene Atlas206227_atCerebellumPeduncles4.20011.270Details
BioGPS Gene Atlas206227_atCiliaryGanglion2.60011.270Details
BioGPS Gene Atlas206227_atCingulateCortex3.80011.270Details
BioGPS Gene Atlas206227_atColorectaladenocarcinoma3.70011.270Details
BioGPS Gene Atlas206227_atDorsalRootGanglion2.85011.270Details
BioGPS Gene Atlas206227_atFetalThyroid3.65011.270Details
BioGPS Gene Atlas206227_atFetalbrain3.75011.270Details
BioGPS Gene Atlas206227_atFetalliver3.20011.270Details
BioGPS Gene Atlas206227_atFetallung3.15011.270Details
BioGPS Gene Atlas206227_atGlobusPallidus2.75011.270Details
BioGPS Gene Atlas206227_atHeart18.50011.270Details
BioGPS Gene Atlas206227_atHypothalamus4.05011.270Details
BioGPS Gene Atlas206227_atKidney3.00011.270Details
BioGPS Gene Atlas206227_atLeukemia_chronicMyelogenousK-5623.35011.270Details
BioGPS Gene Atlas206227_atLeukemia_promyelocytic-HL-603.30011.270Details
BioGPS Gene Atlas206227_atLeukemialymphoblastic(MOLT-4)3.00011.270Details
BioGPS Gene Atlas206227_atLiver4.85011.270Details
BioGPS Gene Atlas206227_atLung4.15011.270Details
BioGPS Gene Atlas206227_atLymphnode3.20011.270Details
BioGPS Gene Atlas206227_atLymphoma_burkitts(Daudi)4.70011.270Details
BioGPS Gene Atlas206227_atLymphoma_burkitts(Raji)5.15011.270Details
BioGPS Gene Atlas206227_atMedullaOblongata3.45011.270Details
BioGPS Gene Atlas206227_atOccipitalLobe3.35011.270Details
BioGPS Gene Atlas206227_atOlfactoryBulb37.70011.270Details
BioGPS Gene Atlas206227_atOvary2.45011.270Details
BioGPS Gene Atlas206227_atPancreas2.95011.270Details
BioGPS Gene Atlas206227_atPancreaticIslet4.00011.270Details
BioGPS Gene Atlas206227_atParietalLobe3.85011.270Details
BioGPS Gene Atlas206227_atPituitary4.35011.270Details
BioGPS Gene Atlas206227_atPlacenta3.90011.270Details
BioGPS Gene Atlas206227_atPons5.30011.270Details
BioGPS Gene Atlas206227_atPrefrontalCortex4.60011.270Details
BioGPS Gene Atlas206227_atProstate6.75011.270Details
BioGPS Gene Atlas206227_atSalivarygland3.25011.270Details
BioGPS Gene Atlas206227_atSkeletalMuscle4.35011.270Details
BioGPS Gene Atlas206227_atSkin2.85011.270Details
BioGPS Gene Atlas206227_atSmoothMuscle4.15011.270Details
BioGPS Gene Atlas206227_atSpinalcord4.00011.270Details
BioGPS Gene Atlas206227_atSubthalamicNucleus3.40011.270Details
BioGPS Gene Atlas206227_atSuperiorCervicalGanglion4.45011.270Details
BioGPS Gene Atlas206227_atTemporalLobe3.40011.270Details
BioGPS Gene Atlas206227_atTestis13.20011.270Details
BioGPS Gene Atlas206227_atTestisGermCell23.60011.270Details
BioGPS Gene Atlas206227_atTestisIntersitial6.45011.270Details
BioGPS Gene Atlas206227_atTestisLeydigCell5.90011.270Details
BioGPS Gene Atlas206227_atTestisSeminiferousTubule3.70011.270Details
BioGPS Gene Atlas206227_atThalamus3.75011.270Details
BioGPS Gene Atlas206227_atThymus3.85011.270Details
BioGPS Gene Atlas206227_atThyroid4.70011.270Details
BioGPS Gene Atlas206227_atTongue139.70011.270Details
BioGPS Gene Atlas206227_atTonsil3.60011.270Details
BioGPS Gene Atlas206227_atTrachea12.35011.270Details
BioGPS Gene Atlas206227_atTrigeminalGanglion12.60011.270Details
BioGPS Gene Atlas206227_atUterus9.00011.270Details
BioGPS Gene Atlas206227_atUterusCorpus5.50011.270Details
BioGPS Gene Atlas206227_atWholeBlood4.10011.270Details
BioGPS Gene Atlas206227_atWholebrain3.15011.270Details
BioGPS Gene Atlas206227_atcolon5.00011.270Details
BioGPS Gene Atlas206227_atpineal_day6.56011.270Details
BioGPS Gene Atlas206227_atpineal_night7.88011.270Details
BioGPS Gene Atlas206227_atretina4.55011.270Details
BioGPS Gene Atlas206227_atsmall_intestine7.30011.270Details
BioGPS NCI60206227_at7863.4084.380Details
BioGPS NCI60206227_atA1723.2354.380Details
BioGPS NCI60206227_atA2043.3374.380Details
BioGPS NCI60206227_atA3613.3724.380Details
BioGPS NCI60206227_atA4983.3484.380Details
BioGPS NCI60206227_atA5493.3944.380Details
BioGPS NCI60206227_atACC33.4414.380Details
BioGPS NCI60206227_atACHN3.2174.380Details
BioGPS NCI60206227_atALVA313.4604.380Details
BioGPS NCI60206227_atCAKI13.4374.380Details
BioGPS NCI60206227_atCCRT CEM3.6314.380Details
BioGPS NCI60206227_atCOLO2053.3634.380Details
BioGPS NCI60206227_atDLD13.2984.380Details
BioGPS NCI60206227_atDU1453.2294.380Details
BioGPS NCI60206227_atEKVX3.2684.380Details
BioGPS NCI60206227_atGM1333.4184.380Details
BioGPS NCI60206227_atGM16003.4514.380Details
BioGPS NCI60206227_atGM23133.3834.380Details
BioGPS NCI60206227_atGM23453.3504.380Details
BioGPS NCI60206227_atGM24933.4554.380Details
BioGPS NCI60206227_atGM973.5954.380Details
BioGPS NCI60206227_atHCC29983.1354.380Details
BioGPS NCI60206227_atHCT1163.3324.380Details
BioGPS NCI60206227_atHCT153.1974.380Details
BioGPS NCI60206227_atHEK 293 T-rex3.3864.380Details
BioGPS NCI60206227_atHEK 293T3.3304.380Details
BioGPS NCI60206227_atHEK2933.3504.380Details
BioGPS NCI60206227_atHELA3.1944.380Details
BioGPS NCI60206227_atHEPG23.3284.380Details
BioGPS NCI60206227_atHL603.3934.380Details
BioGPS NCI60206227_atHOP623.3454.380Details
BioGPS NCI60206227_atHOP923.2834.380Details
BioGPS NCI60206227_atHS578T3.3084.380Details
BioGPS NCI60206227_atHSG3.2654.380Details
BioGPS NCI60206227_atHT10803.3254.380Details
BioGPS NCI60206227_atHT293.4804.380Details
BioGPS NCI60206227_atIGROV13.3134.380Details
BioGPS NCI60206227_atIOSE803.3224.380Details
BioGPS NCI60206227_atJURKAT3.3334.380Details
BioGPS NCI60206227_atK5623.5134.380Details
BioGPS NCI60206227_atKM123.4294.380Details
BioGPS NCI60206227_atLN183.2054.380Details
BioGPS NCI60206227_atLNCAP3.3434.380Details
BioGPS NCI60206227_atLOX IMVI3.3334.380Details
BioGPS NCI60206227_atM143.3044.380Details
BioGPS NCI60206227_atMALME 3M3.4754.380Details
BioGPS NCI60206227_atMCF73.2684.380Details
BioGPS NCI60206227_atMD MB2313.3664.380Details
BioGPS NCI60206227_atMDA MB4353.5094.380Details
BioGPS NCI60206227_atMOLT43.3994.380Details
BioGPS NCI60206227_atNCI 4603.4134.380Details
BioGPS NCI60206227_atNCI H2263.3944.380Details
BioGPS NCI60206227_atNCI H233.3404.380Details
BioGPS NCI60206227_atNCI H322M3.3454.380Details
BioGPS NCI60206227_atNCVADR RES3.2304.380Details
BioGPS NCI60206227_atOVCAR33.4604.380Details
BioGPS NCI60206227_atOVCAR4115.3394.380Details
BioGPS NCI60206227_atOVCAR53.2994.380Details
BioGPS NCI60206227_atOVCAR83.2094.380Details
BioGPS NCI60206227_atPANC13.3754.380Details
BioGPS NCI60206227_atRL73.3924.380Details
BioGPS NCI60206227_atRPMI 82263.3744.380Details
BioGPS NCI60206227_atRS118463.4354.380Details
BioGPS NCI60206227_atRXF3933.3244.380Details
BioGPS NCI60206227_atSAOS23.3784.380Details
BioGPS NCI60206227_atSF2683.3404.380Details
BioGPS NCI60206227_atSF2953.2974.380Details
BioGPS NCI60206227_atSF5393.2224.380Details
BioGPS NCI60206227_atSHSYSY+RA3.2654.380Details
BioGPS NCI60206227_atSHSYSY-RA3.3114.380Details
BioGPS NCI60206227_atSKMEL23.3334.380Details
BioGPS NCI60206227_atSKMEL283.3454.380Details
BioGPS NCI60206227_atSKMEL53.2664.380Details
BioGPS NCI60206227_atSKOV33.4204.380Details
BioGPS NCI60206227_atSN12C3.3184.380Details
BioGPS NCI60206227_atSNB193.2244.380Details
BioGPS NCI60206227_atSNB753.3304.380Details
BioGPS NCI60206227_atSR3.3834.380Details
BioGPS NCI60206227_atSW6203.3684.380Details
BioGPS NCI60206227_atT243.4004.380Details
BioGPS NCI60206227_atT3M43.4234.380Details
BioGPS NCI60206227_atTK103.3404.380Details
BioGPS NCI60206227_atU1183.2844.380Details
BioGPS NCI60206227_atU1383.2114.380Details
BioGPS NCI60206227_atU20S3.4264.380Details
BioGPS NCI60206227_atU2513.3024.380Details
BioGPS NCI60206227_atU873.2884.380Details
BioGPS NCI60206227_atUACC2573.2934.380Details
BioGPS NCI60206227_atUACC623.3684.380Details
BioGPS NCI60206227_atUO313.2584.380Details
BioGPS NCI60206227_atZR75_13.4034.380Details
BioGPS NCI60206227_atastrocytes3.3694.380Details
BioGPS NCI60206227_athuh-73.4184.380Details