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Gene ID: 63924 | CIDEC Antibody Resource


CIDEC Antibody Resource
Gene Full Name: 
cell death-inducing DFFA-like effector c
Uniprot: 
Q96AQ7
Protein Name: 
cell death activator CIDE-3
Nucleotide: 
NM_001199552
Alias: 
CIDE3;FPLD5;FSP27;CIDE-3;
Ensembl: 
ENSG00000187288
Location: 
3p25.3
HPRD: 
13060
NCBI Gene: 
63924
MIM: 
612120

Summary: 
This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Function: 
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
Subcellular location: 
Nucleus. Endoplasmic reticulum. Lipid droplet. Note: Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
PTM: 
Ubl conjugation;
Disease: 
In omental adipose tissue of obese patients matched for BMI, expression levels tend to correlate with insulin sensitivity. Expression is increased 2-3 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. This effect is not significant in subcutaneous adipose tissue (). In subcutaneous adipose tissue of diabetic patients, tends to negatively correlate with body mass index and total fat mass, independently of insulin sensitivity (). Lipodystrophy, familial partial, 5 (FPLD5) [MIM:615238]: A form of lipodystrophy characterized by loss of subcutaneous adipose tissue affecting limb, femorogluteal and subcutaneous abdominal fat, preservation of visceral, neck and axilliary fat, hepatomegaly, hepatic steatosis and insulin-resistant diabetes. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB13765 CIDEC antibody - center region (OAAB13765) Human WB 400ul $289 Details
Polyclonal Antibody OAAF02894 CIDEC Antibody (OAAF02894) Polyclonal Human IHC, IF, ELISA 100 ug $229 Details

Show all CIDEC antibodies


Product Images
CIDEC antibody - center region (OAAB13765) in MDA-MB453 cells using Western Blot

Sample Type: MDA-MB453

CIDEC Antibody (OAAF02894) in HeLa cells using Immunofluorescence

Sample Type: HeLa

CIDEC Antibody (OAAF02894) in Human colon carcinoma cells using Immunohistochemistry

Sample Type: Human colon carcinoma


CIDEC Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP51932 Bovine CIDEC antibody; Bos taurus CIDEC antibody F1MN90 79.0%
ARP51932 Cat CIDEC antibody; Felis catus CIDEC antibody M3WK99 79.0%
ARP51932 Chimpanzee CIDEC antibody; Pan troglodytes CIDEC antibody H2QM10 86.0%
ARP51932 Chimpanzee CIDEC antibody; Pan troglodytes CIDEC antibody K7C1U9 86.0%
ARP51932 European domestic ferret CIDEC antibody; Mustela putorius furo CIDEC antibody M3Z0B7 79.0%
ARP51932 European seabass CIDEC antibody; Dicentrarchus labrax CIDEC antibody E6ZFV7 83.0%
ARP51932 Giant panda CIDEC antibody; Ailuropoda melanoleuca CIDEC antibody G1MCP7 79.0%
ARP51932 Human CIDEC antibody; Homo sapiens CIDEC antibody Q96AQ7-2 86.0%
ARP51932 Human CIDEC antibody; Homo sapiens CIDEC antibody Q96AQ7-4 86.0%
ARP51932 Human CIDEC antibody; Homo sapiens CIDEC antibody Q96AQ7 86.0%
ARP51932 Mouse CIDEC antibody; Mus musculus CIDEC antibody E9QMZ0 86.0%
ARP51932 Mouse CIDEC antibody; Mus musculus CIDEC antibody P56198 86.0%
ARP51932 Rabbit CIDEC antibody; Oryctolagus cuniculus CIDEC antibody G1SNM7 79.0%
ARP51932 Rat CIDEC antibody; Rattus norvegicus CIDEC antibody Q5XI33 86.0%
ARP51932 Rhesus macaque CIDEC antibody; Macaca mulatta CIDEC antibody F6R978 86.0%
ARP51932 Small-eared galago CIDEC antibody; Otolemur garnettii CIDEC antibody H0WTW6 79.0%
ARP51932 Southern platyfish CIDEC antibody; Xiphophorus maculatus CIDEC antibody M4A767 83.0%
ARP51932 Sumatran orangutan CIDEC antibody; Pongo abelii CIDEC antibody K7ET86 86.0%
ARP51932 Thirteen-lined ground squirrel CIDEC antibody; Spermophilus tridecemlineatus CIDEC antibody I3LZU5 79.0%
ARP51932 White-tufted-ear marmoset CIDEC antibody; Callithrix jacchus CIDEC antibody F7HKS1 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas219398_at721_B_lymphoblasts5.40010.790Details
BioGPS Gene Atlas219398_atAdipocyte528.05010.790Details
BioGPS Gene Atlas219398_atAdrenalCortex4.65010.790Details
BioGPS Gene Atlas219398_atAdrenalgland4.95010.790Details
BioGPS Gene Atlas219398_atAmygdala4.60010.790Details
BioGPS Gene Atlas219398_atAppendix4.85010.790Details
BioGPS Gene Atlas219398_atAtrioventricularNode3.20010.790Details
BioGPS Gene Atlas219398_atBDCA4+_DentriticCells4.80010.790Details
BioGPS Gene Atlas219398_atBonemarrow4.40010.790Details
BioGPS Gene Atlas219398_atBronchialEpithelialCells4.30010.790Details
BioGPS Gene Atlas219398_atCD105+_Endothelial3.30010.790Details
BioGPS Gene Atlas219398_atCD14+_Monocytes4.60010.790Details
BioGPS Gene Atlas219398_atCD19+_BCells(neg._sel.)4.60010.790Details
BioGPS Gene Atlas219398_atCD33+_Myeloid5.55010.790Details
BioGPS Gene Atlas219398_atCD34+3.80010.790Details
BioGPS Gene Atlas219398_atCD4+_Tcells4.70010.790Details
BioGPS Gene Atlas219398_atCD56+_NKCells5.10010.790Details
BioGPS Gene Atlas219398_atCD71+_EarlyErythroid4.20010.790Details
BioGPS Gene Atlas219398_atCD8+_Tcells4.15010.790Details
BioGPS Gene Atlas219398_atCardiacMyocytes5.55010.790Details
BioGPS Gene Atlas219398_atCaudatenucleus4.00010.790Details
BioGPS Gene Atlas219398_atCerebellum3.65010.790Details
BioGPS Gene Atlas219398_atCerebellumPeduncles5.50010.790Details
BioGPS Gene Atlas219398_atCiliaryGanglion13.20010.790Details
BioGPS Gene Atlas219398_atCingulateCortex7.45010.790Details
BioGPS Gene Atlas219398_atColorectaladenocarcinoma4.30010.790Details
BioGPS Gene Atlas219398_atDorsalRootGanglion3.35010.790Details
BioGPS Gene Atlas219398_atFetalThyroid4.30010.790Details
BioGPS Gene Atlas219398_atFetalbrain4.40010.790Details
BioGPS Gene Atlas219398_atFetalliver3.85010.790Details
BioGPS Gene Atlas219398_atFetallung3.70010.790Details
BioGPS Gene Atlas219398_atGlobusPallidus3.20010.790Details
BioGPS Gene Atlas219398_atHeart11.10010.790Details
BioGPS Gene Atlas219398_atHypothalamus4.85010.790Details
BioGPS Gene Atlas219398_atKidney6.10010.790Details
BioGPS Gene Atlas219398_atLeukemia_chronicMyelogenousK-5623.95010.790Details
BioGPS Gene Atlas219398_atLeukemia_promyelocytic-HL-603.90010.790Details
BioGPS Gene Atlas219398_atLeukemialymphoblastic(MOLT-4)3.55010.790Details
BioGPS Gene Atlas219398_atLiver6.75010.790Details
BioGPS Gene Atlas219398_atLung4.65010.790Details
BioGPS Gene Atlas219398_atLymphnode3.90010.790Details
BioGPS Gene Atlas219398_atLymphoma_burkitts(Daudi)5.60010.790Details
BioGPS Gene Atlas219398_atLymphoma_burkitts(Raji)6.05010.790Details
BioGPS Gene Atlas219398_atMedullaOblongata4.05010.790Details
BioGPS Gene Atlas219398_atOccipitalLobe4.30010.790Details
BioGPS Gene Atlas219398_atOlfactoryBulb3.45010.790Details
BioGPS Gene Atlas219398_atOvary2.90010.790Details
BioGPS Gene Atlas219398_atPancreas3.50010.790Details
BioGPS Gene Atlas219398_atPancreaticIslet4.70010.790Details
BioGPS Gene Atlas219398_atParietalLobe5.50010.790Details
BioGPS Gene Atlas219398_atPituitary5.10010.790Details
BioGPS Gene Atlas219398_atPlacenta4.45010.790Details
BioGPS Gene Atlas219398_atPons4.40010.790Details
BioGPS Gene Atlas219398_atPrefrontalCortex5.35010.790Details
BioGPS Gene Atlas219398_atProstate5.05010.790Details
BioGPS Gene Atlas219398_atSalivarygland3.50010.790Details
BioGPS Gene Atlas219398_atSkeletalMuscle9.90010.790Details
BioGPS Gene Atlas219398_atSkin4.10010.790Details
BioGPS Gene Atlas219398_atSmoothMuscle3.50010.790Details
BioGPS Gene Atlas219398_atSpinalcord4.85010.790Details
BioGPS Gene Atlas219398_atSubthalamicNucleus4.00010.790Details
BioGPS Gene Atlas219398_atSuperiorCervicalGanglion6.60010.790Details
BioGPS Gene Atlas219398_atTemporalLobe7.95010.790Details
BioGPS Gene Atlas219398_atTestis3.80010.790Details
BioGPS Gene Atlas219398_atTestisGermCell3.65010.790Details
BioGPS Gene Atlas219398_atTestisIntersitial3.65010.790Details
BioGPS Gene Atlas219398_atTestisLeydigCell4.30010.790Details
BioGPS Gene Atlas219398_atTestisSeminiferousTubule3.75010.790Details
BioGPS Gene Atlas219398_atThalamus4.50010.790Details
BioGPS Gene Atlas219398_atThymus6.00010.790Details
BioGPS Gene Atlas219398_atThyroid5.35010.790Details
BioGPS Gene Atlas219398_atTongue4.35010.790Details
BioGPS Gene Atlas219398_atTonsil4.20010.790Details
BioGPS Gene Atlas219398_atTrachea5.05010.790Details
BioGPS Gene Atlas219398_atTrigeminalGanglion4.45010.790Details
BioGPS Gene Atlas219398_atUterus3.50010.790Details
BioGPS Gene Atlas219398_atUterusCorpus5.05010.790Details
BioGPS Gene Atlas219398_atWholeBlood4.75010.790Details
BioGPS Gene Atlas219398_atWholebrain4.70010.790Details
BioGPS Gene Atlas219398_atcolon4.40010.790Details
BioGPS Gene Atlas219398_atpineal_day4.06010.790Details
BioGPS Gene Atlas219398_atpineal_night4.82010.790Details
BioGPS Gene Atlas219398_atretina4.37510.790Details
BioGPS Gene Atlas219398_atsmall_intestine9.65010.790Details
BioGPS NCI60219398_at7863.9604.520Details
BioGPS NCI60219398_atA1724.1324.520Details
BioGPS NCI60219398_atA2044.1854.520Details
BioGPS NCI60219398_atA3614.2304.520Details
BioGPS NCI60219398_atA4984.1934.520Details
BioGPS NCI60219398_atA5494.2434.520Details
BioGPS NCI60219398_atACC34.2904.520Details
BioGPS NCI60219398_atACHN4.0274.520Details
BioGPS NCI60219398_atALVA314.2964.520Details
BioGPS NCI60219398_atCAKI14.2764.520Details
BioGPS NCI60219398_atCCRT CEM4.3604.520Details
BioGPS NCI60219398_atCOLO2054.1964.520Details
BioGPS NCI60219398_atDLD14.1554.520Details
BioGPS NCI60219398_atDU1454.1364.520Details
BioGPS NCI60219398_atEKVX3.7704.520Details
BioGPS NCI60219398_atGM1334.3014.520Details
BioGPS NCI60219398_atGM16004.2994.520Details
BioGPS NCI60219398_atGM23134.2664.520Details
BioGPS NCI60219398_atGM23454.2154.520Details
BioGPS NCI60219398_atGM24934.2624.520Details
BioGPS NCI60219398_atGM974.4224.520Details
BioGPS NCI60219398_atHCC29983.9814.520Details
BioGPS NCI60219398_atHCT1164.2054.520Details
BioGPS NCI60219398_atHCT154.0574.520Details
BioGPS NCI60219398_atHEK 293 T-rex4.2344.520Details
BioGPS NCI60219398_atHEK 293T4.2074.520Details
BioGPS NCI60219398_atHEK2934.2234.520Details
BioGPS NCI60219398_atHELA4.0944.520Details
BioGPS NCI60219398_atHEPG27.7884.520Details
BioGPS NCI60219398_atHL6016.9344.520Details
BioGPS NCI60219398_atHOP624.2164.520Details
BioGPS NCI60219398_atHOP924.1354.520Details
BioGPS NCI60219398_atHS578T4.1644.520Details
BioGPS NCI60219398_atHSG4.2744.520Details
BioGPS NCI60219398_atHT10804.1744.520Details
BioGPS NCI60219398_atHT294.0704.520Details
BioGPS NCI60219398_atIGROV14.1694.520Details
BioGPS NCI60219398_atIOSE804.1904.520Details
BioGPS NCI60219398_atJURKAT5.7804.520Details
BioGPS NCI60219398_atK5624.5194.520Details
BioGPS NCI60219398_atKM124.2664.520Details
BioGPS NCI60219398_atLN184.0494.520Details
BioGPS NCI60219398_atLNCAP4.1864.520Details
BioGPS NCI60219398_atLOX IMVI4.1914.520Details
BioGPS NCI60219398_atM144.1574.520Details
BioGPS NCI60219398_atMALME 3M4.3244.520Details
BioGPS NCI60219398_atMCF74.1474.520Details
BioGPS NCI60219398_atMD MB2314.2564.520Details
BioGPS NCI60219398_atMDA MB4354.3664.520Details
BioGPS NCI60219398_atMOLT44.2454.520Details
BioGPS NCI60219398_atNCI 4604.2794.520Details
BioGPS NCI60219398_atNCI H2264.6804.520Details
BioGPS NCI60219398_atNCI H234.4824.520Details
BioGPS NCI60219398_atNCI H322M4.1854.520Details
BioGPS NCI60219398_atNCVADR RES3.9544.520Details
BioGPS NCI60219398_atOVCAR34.2954.520Details
BioGPS NCI60219398_atOVCAR44.1794.520Details
BioGPS NCI60219398_atOVCAR54.1524.520Details
BioGPS NCI60219398_atOVCAR84.1164.520Details
BioGPS NCI60219398_atPANC14.2074.520Details
BioGPS NCI60219398_atRL74.2364.520Details
BioGPS NCI60219398_atRPMI 82264.2404.520Details
BioGPS NCI60219398_atRS118464.2824.520Details
BioGPS NCI60219398_atRXF3934.1644.520Details
BioGPS NCI60219398_atSAOS24.2264.520Details
BioGPS NCI60219398_atSF2684.1944.520Details
BioGPS NCI60219398_atSF2954.1544.520Details
BioGPS NCI60219398_atSF5394.0904.520Details
BioGPS NCI60219398_atSHSYSY+RA4.0604.520Details
BioGPS NCI60219398_atSHSYSY-RA4.1624.520Details
BioGPS NCI60219398_atSKMEL24.1734.520Details
BioGPS NCI60219398_atSKMEL283.9194.520Details
BioGPS NCI60219398_atSKMEL54.1334.520Details
BioGPS NCI60219398_atSKOV34.2414.520Details
BioGPS NCI60219398_atSN12C4.1964.520Details
BioGPS NCI60219398_atSNB193.9774.520Details
BioGPS NCI60219398_atSNB754.1834.520Details
BioGPS NCI60219398_atSR4.2394.520Details
BioGPS NCI60219398_atSW6204.2014.520Details
BioGPS NCI60219398_atT244.2464.520Details
BioGPS NCI60219398_atT3M44.2624.520Details
BioGPS NCI60219398_atTK104.1804.520Details
BioGPS NCI60219398_atU1184.1534.520Details
BioGPS NCI60219398_atU1384.0564.520Details
BioGPS NCI60219398_atU20S4.1174.520Details
BioGPS NCI60219398_atU2514.1614.520Details
BioGPS NCI60219398_atU874.1284.520Details
BioGPS NCI60219398_atUACC2574.3154.520Details
BioGPS NCI60219398_atUACC624.2264.520Details
BioGPS NCI60219398_atUO314.0564.520Details
BioGPS NCI60219398_atZR75_14.2834.520Details
BioGPS NCI60219398_atastrocytes4.2194.520Details
BioGPS NCI60219398_athuh-76.3314.520Details