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Gene ID: 1149 | CIDEA Antibody Resource


CIDEA Antibody Resource
Gene Full Name: 
cell death-inducing DFFA-like effector a
Uniprot: 
O60543
Protein Name: 
cell death activator CIDE-A
Nucleotide: 
NM_001279
Alias: 
CIDE-A;
Ensembl: 
Location: 
18p11.21
HPRD: 
08380
NCBI Gene: 
1149
MIM: 
604440

Summary: 
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
Function: 
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter . Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
Subcellular location: 
Lipid droplet. Nucleus. Note: Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity . These data could not be confirmed ().
PTM: 
Disease: 
In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OASA08378 Cidea Antibody (OASA08378) Mouse WB 0.1mg $360 Details
Polyclonal Antibody OASA08379 Cidea Antibody (OASA08379) Mouse WB , IHC 50ug $265 Details
Polyclonal Antibody ARP51931_P050 CIDEA Antibody (ARP51931_P050) Polyclonal Bovine, Guinea pig, Horse, Human, Mouse, Pig, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP51932_P050 CIDEA Antibody (ARP51932_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody OAAB10355 CIDEA antibody - C - terminal region (OAAB10355) Human WB 400ul $289 Details

Show all CIDEA antibodies


Product Images
CIDEA antibody - C - terminal region (OAAB10355) in CEM cells using Western Blot

Sample Type: CEM

Cidea Antibody (OASA08378) in murine heart cells using Western Blot

Sample Type: murine heart

Cidea Antibody (OASA08379) in  cells using Immunohistochemistry Cidea Antibody (OASA08379) in  cells using Western Blot

CIDEA Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP51932 African clawed frog CIDEA antibody; Xenopus laevis CIDEA antibody Q5U5A1 91.0%
ARP51931 Bovine CIDEA antibody; Bos taurus CIDEA antibody A4FUX1 93.0%
ARP51932 Bovine CIDEA antibody; Bos taurus CIDEA antibody G3N3U3 83.0%
ARP51932 Bovine CIDEA antibody; Bos taurus CIDEA antibody A4FUX1 83.0%
ARP51932 Cat CIDEA antibody; Felis catus CIDEA antibody M3W5Y4 92.0%
ARP51931 Cat CIDEA antibody; Felis catus CIDEA antibody M3W5Y4 79.0%
ARP51931 Chicken CIDEA antibody; Gallus gallus CIDEA antibody R4GKR6 86.0%
ARP51932 Chicken CIDEA antibody; Gallus gallus CIDEA antibody R4GKR6 85.0%
ARP51931 Chinese softshell turtle CIDEA antibody; Pelodiscus sinensis CIDEA antibody K7G370 93.0%
ARP51931 Collared flycatcher CIDEA antibody; Ficedula albicollis CIDEA antibody U3JVB2 93.0%
ARP51932 Collared flycatcher CIDEA antibody; Ficedula albicollis CIDEA antibody U3JVB2 85.0%
ARP51932 Dog CIDEA antibody; Canis familiaris CIDEA antibody E2RQL5 85.0%
ARP51931 Duckbill platypus CIDEA antibody; Ornithorhynchus anatinus CIDEA antibody F7CKF7 86.0%
ARP51932 European domestic ferret CIDEA antibody; Mustela putorius furo CIDEA antibody M3XZH5 92.0%
ARP51932 Giant panda CIDEA antibody; Ailuropoda melanoleuca CIDEA antibody G1M245 92.0%
ARP51932 Gray short-tailed opossum CIDEA antibody; Monodelphis domestica CIDEA antibody F7CB75 86.0%
ARP51932 Horse CIDEA antibody; Equus caballus CIDEA antibody F6ZIJ1 92.0%
ARP51931 Horse CIDEA antibody; Equus caballus CIDEA antibody F6ZIJ1 79.0%
ARP51931 Human CIDEA antibody; Homo sapiens CIDEA antibody O60543 100.0%
ARP51932 Human CIDEA antibody; Homo sapiens CIDEA antibody O60543 100.0%
ARP51931 Human CIDEA antibody; Homo sapiens CIDEA antibody Q8N5P9 100.0%
ARP51932 Human CIDEA antibody; Homo sapiens CIDEA antibody Q8N5P9 100.0%
ARP51931 Mouse CIDEA antibody; Mus musculus CIDEA antibody O70302 100.0%
ARP51932 Mouse CIDEA antibody; Mus musculus CIDEA antibody O70302 100.0%
ARP51931 Pig CIDEA antibody; Sus scrofa CIDEA antibody I3LED4 93.0%
ARP51932 Pig CIDEA antibody; Sus scrofa CIDEA antibody I3LED4 92.0%
ARP51932 Rabbit CIDEA antibody; Oryctolagus cuniculus CIDEA antibody G1T171 86.0%
ARP51932 Rat CIDEA antibody; Rattus norvegicus CIDEA antibody D4ACH9 100.0%
ARP51931 Rat CIDEA antibody; Rattus norvegicus CIDEA antibody D4ACH9 92.0%
ARP51931 Rhesus macaque CIDEA antibody; Macaca mulatta CIDEA antibody F7HDF2 100.0%
ARP51932 Rhesus macaque CIDEA antibody; Macaca mulatta CIDEA antibody F7HDF2 100.0%
ARP51931 Rhesus macaque CIDEA antibody; Macaca mulatta CIDEA antibody F7HDF4 100.0%
ARP51932 Rhesus macaque CIDEA antibody; Macaca mulatta CIDEA antibody F7HDF4 100.0%
ARP51931 Small-eared galago CIDEA antibody; Otolemur garnettii CIDEA antibody H0WTJ3 93.0%
ARP51932 Small-eared galago CIDEA antibody; Otolemur garnettii CIDEA antibody H0WTJ3 93.0%
ARP51931 Sumatran orangutan CIDEA antibody; Pongo abelii CIDEA antibody H2NVT4 100.0%
ARP51932 Sumatran orangutan CIDEA antibody; Pongo abelii CIDEA antibody H2NVT4 100.0%
ARP51932 Tasmanian devil CIDEA antibody; Sarcophilus harrisii CIDEA antibody G3VT92 86.0%
ARP51932 Western clawed frog CIDEA antibody; Xenopus tropicalis CIDEA antibody Q66K97 92.0%
ARP51931 White-tufted-ear marmoset CIDEA antibody; Callithrix jacchus CIDEA antibody F7IRZ3 100.0%
ARP51931 White-tufted-ear marmoset CIDEA antibody; Callithrix jacchus CIDEA antibody F7IS00 100.0%
ARP51932 White-tufted-ear marmoset CIDEA antibody; Callithrix jacchus CIDEA antibody F7H8S2 86.0%
ARP51932 White-tufted-ear marmoset CIDEA antibody; Callithrix jacchus CIDEA antibody F7IRZ3 86.0%
ARP51932 White-tufted-ear marmoset CIDEA antibody; Callithrix jacchus CIDEA antibody F7IS00 86.0%
ARP51931 Zebra finch CIDEA antibody; Taeniopygia guttata CIDEA antibody H0ZH87 93.0%
ARP51932 Zebra finch CIDEA antibody; Taeniopygia guttata CIDEA antibody H0ZH87 85.0%
ARP51932 Zebrafish CIDEA antibody; Danio rerio CIDEA antibody F1QDE3 91.0%
ARP51932 Zebrafish CIDEA antibody; Danio rerio CIDEA antibody F1R0L1 91.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas221295_at721_B_lymphoblasts4.9504.070Details
BioGPS Gene Atlas221295_atAdipocyte3.9004.070Details
BioGPS Gene Atlas221295_atAdrenalCortex4.1504.070Details
BioGPS Gene Atlas221295_atAdrenalgland3.3004.070Details
BioGPS Gene Atlas221295_atAmygdala4.2504.070Details
BioGPS Gene Atlas221295_atAppendix3.9504.070Details
BioGPS Gene Atlas221295_atAtrioventricularNode3.0004.070Details
BioGPS Gene Atlas221295_atBDCA4+_DentriticCells4.4504.070Details
BioGPS Gene Atlas221295_atBonemarrow3.9004.070Details
BioGPS Gene Atlas221295_atBronchialEpithelialCells3.9504.070Details
BioGPS Gene Atlas221295_atCD105+_Endothelial4.8004.070Details
BioGPS Gene Atlas221295_atCD14+_Monocytes4.2004.070Details
BioGPS Gene Atlas221295_atCD19+_BCells(neg._sel.)4.2504.070Details
BioGPS Gene Atlas221295_atCD33+_Myeloid5.6504.070Details
BioGPS Gene Atlas221295_atCD34+5.0004.070Details
BioGPS Gene Atlas221295_atCD4+_Tcells4.3504.070Details
BioGPS Gene Atlas221295_atCD56+_NKCells4.7504.070Details
BioGPS Gene Atlas221295_atCD71+_EarlyErythroid3.7004.070Details
BioGPS Gene Atlas221295_atCD8+_Tcells3.9004.070Details
BioGPS Gene Atlas221295_atCardiacMyocytes5.0004.070Details
BioGPS Gene Atlas221295_atCaudatenucleus3.5504.070Details
BioGPS Gene Atlas221295_atCerebellum3.2004.070Details
BioGPS Gene Atlas221295_atCerebellumPeduncles6.0004.070Details
BioGPS Gene Atlas221295_atCiliaryGanglion4.6504.070Details
BioGPS Gene Atlas221295_atCingulateCortex4.0504.070Details
BioGPS Gene Atlas221295_atColorectaladenocarcinoma3.9504.070Details
BioGPS Gene Atlas221295_atDorsalRootGanglion3.2504.070Details
BioGPS Gene Atlas221295_atFetalThyroid3.8004.070Details
BioGPS Gene Atlas221295_atFetalbrain3.9504.070Details
BioGPS Gene Atlas221295_atFetalliver3.4004.070Details
BioGPS Gene Atlas221295_atFetallung3.3504.070Details
BioGPS Gene Atlas221295_atGlobusPallidus2.9504.070Details
BioGPS Gene Atlas221295_atHeart5.1004.070Details
BioGPS Gene Atlas221295_atHypothalamus4.2504.070Details
BioGPS Gene Atlas221295_atKidney3.1504.070Details
BioGPS Gene Atlas221295_atLeukemia_chronicMyelogenousK-5623.5504.070Details
BioGPS Gene Atlas221295_atLeukemia_promyelocytic-HL-603.5004.070Details
BioGPS Gene Atlas221295_atLeukemialymphoblastic(MOLT-4)3.2004.070Details
BioGPS Gene Atlas221295_atLiver5.3504.070Details
BioGPS Gene Atlas221295_atLung4.4004.070Details
BioGPS Gene Atlas221295_atLymphnode3.4004.070Details
BioGPS Gene Atlas221295_atLymphoma_burkitts(Daudi)5.0004.070Details
BioGPS Gene Atlas221295_atLymphoma_burkitts(Raji)5.5504.070Details
BioGPS Gene Atlas221295_atMedullaOblongata4.1004.070Details
BioGPS Gene Atlas221295_atOccipitalLobe3.5504.070Details
BioGPS Gene Atlas221295_atOlfactoryBulb3.1004.070Details
BioGPS Gene Atlas221295_atOvary2.6004.070Details
BioGPS Gene Atlas221295_atPancreas3.6004.070Details
BioGPS Gene Atlas221295_atPancreaticIslet4.2504.070Details
BioGPS Gene Atlas221295_atParietalLobe4.1504.070Details
BioGPS Gene Atlas221295_atPituitary4.6004.070Details
BioGPS Gene Atlas221295_atPlacenta4.1004.070Details
BioGPS Gene Atlas221295_atPons3.9004.070Details
BioGPS Gene Atlas221295_atPrefrontalCortex4.9504.070Details
BioGPS Gene Atlas221295_atProstate4.7004.070Details
BioGPS Gene Atlas221295_atSalivarygland3.1504.070Details
BioGPS Gene Atlas221295_atSkeletalMuscle4.5504.070Details
BioGPS Gene Atlas221295_atSkin3.0004.070Details
BioGPS Gene Atlas221295_atSmoothMuscle4.5004.070Details
BioGPS Gene Atlas221295_atSpinalcord4.2004.070Details
BioGPS Gene Atlas221295_atSubthalamicNucleus3.6504.070Details
BioGPS Gene Atlas221295_atSuperiorCervicalGanglion4.4004.070Details
BioGPS Gene Atlas221295_atTemporalLobe3.6004.070Details
BioGPS Gene Atlas221295_atTestis3.4004.070Details
BioGPS Gene Atlas221295_atTestisGermCell3.3004.070Details
BioGPS Gene Atlas221295_atTestisIntersitial3.3004.070Details
BioGPS Gene Atlas221295_atTestisLeydigCell4.3004.070Details
BioGPS Gene Atlas221295_atTestisSeminiferousTubule3.4004.070Details
BioGPS Gene Atlas221295_atThalamus4.0004.070Details
BioGPS Gene Atlas221295_atThymus3.7004.070Details
BioGPS Gene Atlas221295_atThyroid5.0504.070Details
BioGPS Gene Atlas221295_atTongue3.8504.070Details
BioGPS Gene Atlas221295_atTonsil3.8004.070Details
BioGPS Gene Atlas221295_atTrachea3.3004.070Details
BioGPS Gene Atlas221295_atTrigeminalGanglion4.1504.070Details
BioGPS Gene Atlas221295_atUterus3.2504.070Details
BioGPS Gene Atlas221295_atUterusCorpus3.4504.070Details
BioGPS Gene Atlas221295_atWholeBlood4.3004.070Details
BioGPS Gene Atlas221295_atWholebrain3.4004.070Details
BioGPS Gene Atlas221295_atcolon3.9504.070Details
BioGPS Gene Atlas221295_atpineal_day4.9204.070Details
BioGPS Gene Atlas221295_atpineal_night4.8404.070Details
BioGPS Gene Atlas221295_atretina4.7754.070Details
BioGPS Gene Atlas221295_atsmall_intestine3.8504.070Details
BioGPS NCI60221295_at7864.1604.090Details
BioGPS NCI60221295_atA1723.8824.090Details
BioGPS NCI60221295_atA2043.9864.090Details
BioGPS NCI60221295_atA3614.0994.090Details
BioGPS NCI60221295_atA4984.0374.090Details
BioGPS NCI60221295_atA5494.0804.090Details
BioGPS NCI60221295_atACC34.1374.090Details
BioGPS NCI60221295_atACHN3.7874.090Details
BioGPS NCI60221295_atALVA314.2854.090Details
BioGPS NCI60221295_atCAKI14.2434.090Details
BioGPS NCI60221295_atCCRT CEM4.2994.090Details
BioGPS NCI60221295_atCOLO2054.0924.090Details
BioGPS NCI60221295_atDLD13.9834.090Details
BioGPS NCI60221295_atDU1453.8724.090Details
BioGPS NCI60221295_atEKVX3.9254.090Details
BioGPS NCI60221295_atGM1334.1344.090Details
BioGPS NCI60221295_atGM16004.1404.090Details
BioGPS NCI60221295_atGM23134.1164.090Details
BioGPS NCI60221295_atGM23454.0634.090Details
BioGPS NCI60221295_atGM24934.1574.090Details
BioGPS NCI60221295_atGM974.4834.090Details
BioGPS NCI60221295_atHCC29983.7654.090Details
BioGPS NCI60221295_atHCT1164.0294.090Details
BioGPS NCI60221295_atHCT153.9004.090Details
BioGPS NCI60221295_atHEK 293 T-rex4.1414.090Details
BioGPS NCI60221295_atHEK 293T4.0454.090Details
BioGPS NCI60221295_atHEK2934.0524.090Details
BioGPS NCI60221295_atHELA3.8634.090Details
BioGPS NCI60221295_atHEPG24.0144.090Details
BioGPS NCI60221295_atHL604.1224.090Details
BioGPS NCI60221295_atHOP624.0444.090Details
BioGPS NCI60221295_atHOP923.9784.090Details
BioGPS NCI60221295_atHS578T3.9624.090Details
BioGPS NCI60221295_atHSG3.8934.090Details
BioGPS NCI60221295_atHT10804.0164.090Details
BioGPS NCI60221295_atHT294.3184.090Details
BioGPS NCI60221295_atIGROV13.9984.090Details
BioGPS NCI60221295_atIOSE804.0424.090Details
BioGPS NCI60221295_atJURKAT4.0314.090Details
BioGPS NCI60221295_atK5624.3834.090Details
BioGPS NCI60221295_atKM124.2634.090Details
BioGPS NCI60221295_atLN183.9014.090Details
BioGPS NCI60221295_atLNCAP4.0534.090Details
BioGPS NCI60221295_atLOX IMVI5.6224.090Details
BioGPS NCI60221295_atM143.9924.090Details
BioGPS NCI60221295_atMALME 3M4.1754.090Details
BioGPS NCI60221295_atMCF73.9534.090Details
BioGPS NCI60221295_atMD MB2314.1134.090Details
BioGPS NCI60221295_atMDA MB4354.3994.090Details
BioGPS NCI60221295_atMOLT44.1714.090Details
BioGPS NCI60221295_atNCI 4604.1224.090Details
BioGPS NCI60221295_atNCI H2264.1684.090Details
BioGPS NCI60221295_atNCI H234.0164.090Details
BioGPS NCI60221295_atNCI H322M4.0274.090Details
BioGPS NCI60221295_atNCVADR RES3.8174.090Details
BioGPS NCI60221295_atOVCAR34.1314.090Details
BioGPS NCI60221295_atOVCAR44.0224.090Details
BioGPS NCI60221295_atOVCAR53.9984.090Details
BioGPS NCI60221295_atOVCAR83.7964.090Details
BioGPS NCI60221295_atPANC14.1204.090Details
BioGPS NCI60221295_atRL74.1024.090Details
BioGPS NCI60221295_atRPMI 82264.0914.090Details
BioGPS NCI60221295_atRS118464.2424.090Details
BioGPS NCI60221295_atRXF3934.0074.090Details
BioGPS NCI60221295_atSAOS24.0884.090Details
BioGPS NCI60221295_atSF2684.0414.090Details
BioGPS NCI60221295_atSF2953.9874.090Details
BioGPS NCI60221295_atSF5393.8624.090Details
BioGPS NCI60221295_atSHSYSY+RA3.9494.090Details
BioGPS NCI60221295_atSHSYSY-RA4.0124.090Details
BioGPS NCI60221295_atSKMEL24.0194.090Details
BioGPS NCI60221295_atSKMEL284.0344.090Details
BioGPS NCI60221295_atSKMEL53.9304.090Details
BioGPS NCI60221295_atSKOV34.0924.090Details
BioGPS NCI60221295_atSN12C7.2674.090Details
BioGPS NCI60221295_atSNB193.9104.090Details
BioGPS NCI60221295_atSNB754.0194.090Details
BioGPS NCI60221295_atSR4.1034.090Details
BioGPS NCI60221295_atSW6204.1204.090Details
BioGPS NCI60221295_atT244.1574.090Details
BioGPS NCI60221295_atT3M44.2314.090Details
BioGPS NCI60221295_atTK104.0374.090Details
BioGPS NCI60221295_atU1183.9454.090Details
BioGPS NCI60221295_atU1383.8724.090Details
BioGPS NCI60221295_atU20S4.0334.090Details
BioGPS NCI60221295_atU2513.9974.090Details
BioGPS NCI60221295_atU873.9854.090Details
BioGPS NCI60221295_atUACC2574.0004.090Details
BioGPS NCI60221295_atUACC624.0724.090Details
BioGPS NCI60221295_atUO313.9264.090Details
BioGPS NCI60221295_atZR75_14.0824.090Details
BioGPS NCI60221295_atastrocytes4.0514.090Details
BioGPS NCI60221295_athuh-74.1634.090Details