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Gene ID: 4166 | CHST6 Antibody Resource


CHST6 Antibody Resource
Gene Full Name: 
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
Uniprot: 
Q9GZX3
Protein Name: 
carbohydrate sulfotransferase 6
Nucleotide: 
NM_021615
Alias: 
MCDC1;
Ensembl: 
Location: 
16q22
HPRD: 
05597
NCBI Gene: 
4166
MIM: 
605294

Summary: 
The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). [provided by RefSeq, Jan 2010]
Function: 
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures.
Subcellular location: 
Golgi apparatus membrane; Single-pass type II membrane protein.
PTM: 
Glycoprotein;
Disease: 
Macular dystrophy, corneal, 1 (MCDC1) [MIM:217800]: An ocular disease characterized by bilateral, progressive corneal opacification, and reduced corneal sensitivity. Onset occurs in the first decade, usually between ages 5 and 9. Painful attacks with photophobia, foreign body sensations, and recurrent erosions occur in most patients. The disease is due to deposition of an unsulfated keratan sulfate both within the intracellular space (within the keratocytes and endothelial cells) and in the extracellular corneal stroma. Macular corneal dystrophy is divided into the clinically indistinguishable types I, IA, and II based on analysis of the normally sulfated, or antigenic, keratan sulfate levels in serum and immunohistochemical evaluation of the cornea. Patients with types I and IA macular corneal dystrophy have undetectable serum levels of antigenic keratan sulfate, whereas those with type II macular corneal dystrophy have normal or low levels, depending on the population examined. Note: The disease is caused by mutations affecting the gene represented in this entry. CHST6 homozygous missense mutations have been observed in patients with macular corneal dystrophy type I, while type II patients show a large deletion and replacement in the upstream region of CHST6. The only missense mutation for type II is Cys-50, which is heterozygous with a replacement in the upstream region on the other allele of CHST6.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP48878_P050 CHST6 antibody - middle region (ARP48878_P050) Polyclonal Bovine, Human WB 50ug $289 Details
Polyclonal Antibody ARP48877_P050 CHST6 antibody - middle region (ARP48877_P050) Polyclonal Bovine, Dog, Human WB 50ug $289 Details
Polyclonal Antibody OAAB08613 CHST6 antibody - C - terminal region (OAAB08613) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAAF03426 CHST6 Antibody (OAAF03426) Polyclonal Human IF, ELISA 100 ug $289 Details

Show all CHST6 antibodies


Product Images
CHST6 antibody - middle region (ARP48877_P050) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

CHST6 antibody - middle region (ARP48878_P050) in Human 293T cells using Western Blot

Sample Type: Human 293T

CHST6 antibody - C - terminal region (OAAB08613) in Human Brain cells using Immunohistochemistry

Sample Type: Human Brain

CHST6 antibody - C - terminal region (OAAB08613) in NCI-H460 cells using Western Blot

Sample Type: NCI-H460

CHST6 Antibody (OAAF03426) in A549 cells using Immunofluorescence

Sample Type: A549


CHST6 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP35787 African clawed frog CHST6 antibody; Xenopus laevis CHST6 antibody Q6GN39 92.0%
ARP48897 African clawed frog CHST6 antibody; Xenopus laevis CHST6 antibody Q6GN39 86.0%
ARP48877 Bovine CHST6 antibody; Bos taurus CHST6 antibody E1BK55 93.0%
ARP48897 Bovine CHST6 antibody; Bos taurus CHST6 antibody E1BK55 93.0%
ARP48878 Bovine CHST6 antibody; Bos taurus CHST6 antibody E1BK55 79.0%
ARP35787 Chicken CHST6 antibody; Gallus gallus CHST6 antibody E1C5F3 92.0%
ARP48897 Chicken CHST6 antibody; Gallus gallus CHST6 antibody E1C5F3 86.0%
ARP48877 Chimpanzee CHST6 antibody; Pan troglodytes CHST6 antibody H2RGY0 100.0%
ARP48878 Chimpanzee CHST6 antibody; Pan troglodytes CHST6 antibody H2RGY0 100.0%
ARP48897 Chimpanzee CHST6 antibody; Pan troglodytes CHST6 antibody H2RGY0 86.0%
ARP48898 Chimpanzee CHST6 antibody; Pan troglodytes CHST6 antibody H2RGY0 86.0%
ARP35787 Chimpanzee CHST6 antibody; Pan troglodytes CHST6 antibody H2RGY0 79.0%
ARP48877 Dog CHST6 antibody; Canis familiaris CHST6 antibody E2RSN9 100.0%
ARP48897 Dog CHST6 antibody; Canis familiaris CHST6 antibody E2RSN9 93.0%
ARP48877 Giant panda CHST6 antibody; Ailuropoda melanoleuca CHST6 antibody G1MMB0 100.0%
ARP48897 Giant panda CHST6 antibody; Ailuropoda melanoleuca CHST6 antibody G1MMB0 93.0%
ARP48878 Giant panda CHST6 antibody; Ailuropoda melanoleuca CHST6 antibody G1MMB0 86.0%
ARP48898 Giant panda CHST6 antibody; Ailuropoda melanoleuca CHST6 antibody G1MMB0 86.0%
ARP48877 Human CHST6 antibody; Homo sapiens CHST6 antibody Q9GZX3 100.0%
ARP48878 Human CHST6 antibody; Homo sapiens CHST6 antibody Q9GZX3 100.0%
ARP48897 Human CHST6 antibody; Homo sapiens CHST6 antibody Q9GZX3 86.0%
ARP48898 Human CHST6 antibody; Homo sapiens CHST6 antibody Q9GZX3 86.0%
ARP48897 Human CHST6 antibody; Homo sapiens CHST6 antibody D6QZA2 83.0%
ARP35787 Human CHST6 antibody; Homo sapiens CHST6 antibody Q9GZX3 79.0%
ARP48877 Northern white-cheeked gibbon CHST6 antibody; Nomascus leucogenys CHST6 antibody G1RRF5 100.0%
ARP48878 Northern white-cheeked gibbon CHST6 antibody; Nomascus leucogenys CHST6 antibody G1RRF5 93.0%
ARP48897 Northern white-cheeked gibbon CHST6 antibody; Nomascus leucogenys CHST6 antibody G1RRF5 86.0%
ARP48898 Northern white-cheeked gibbon CHST6 antibody; Nomascus leucogenys CHST6 antibody G1RRF5 86.0%
ARP35787 Northern white-cheeked gibbon CHST6 antibody; Nomascus leucogenys CHST6 antibody G1RRF5 79.0%
ARP48877 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody H9F434 100.0%
ARP48878 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody H9F434 100.0%
ARP48877 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody F6S4Z1 100.0%
ARP48878 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody F6S4Z1 100.0%
ARP48897 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody H9EZF3 93.0%
ARP48897 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody F6S4Z1 93.0%
ARP48898 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody H9F434 86.0%
ARP48898 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody F6S4Z1 86.0%
ARP35787 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody H9EZF3 79.0%
ARP35787 Rhesus macaque CHST6 antibody; Macaca mulatta CHST6 antibody F6S4Z1 79.0%
ARP48897 Spotted green pufferfish CHST6 antibody; Tetraodon nigroviridis CHST6 antibody H3CTW3 86.0%
ARP35787 Spotted green pufferfish CHST6 antibody; Tetraodon nigroviridis CHST6 antibody H3CTW3 79.0%
ARP48877 Sumatran orangutan CHST6 antibody; Pongo abelii CHST6 antibody H2NRI4 100.0%
ARP48878 Sumatran orangutan CHST6 antibody; Pongo abelii CHST6 antibody H2NRI4 100.0%
ARP48897 Sumatran orangutan CHST6 antibody; Pongo abelii CHST6 antibody H2NRI4 86.0%
ARP48898 Sumatran orangutan CHST6 antibody; Pongo abelii CHST6 antibody H2NRI4 86.0%
ARP35787 Sumatran orangutan CHST6 antibody; Pongo abelii CHST6 antibody H2NRI4 79.0%
ARP35787 Three-spined stickleback CHST6 antibody; Gasterosteus aculeatus CHST6 antibody G3NBU1 86.0%
ARP48897 Three-spined stickleback CHST6 antibody; Gasterosteus aculeatus CHST6 antibody G3NBU1 79.0%
ARP35787 Western clawed frog CHST6 antibody; Xenopus tropicalis CHST6 antibody F7B638 92.0%
ARP48897 Western clawed frog CHST6 antibody; Xenopus tropicalis CHST6 antibody F7B638 86.0%
ARP48898 Western clawed frog CHST6 antibody; Xenopus tropicalis CHST6 antibody F7B638 79.0%
ARP48877 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3BNH5 100.0%
ARP48877 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3C6I3 100.0%
ARP48877 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DM59 100.0%
ARP48877 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody F7ITB0 100.0%
ARP48897 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DM59 93.0%
ARP48897 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DXI4 93.0%
ARP48897 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3BNH5 93.0%
ARP48897 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3C6I3 93.0%
ARP48897 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody F7ITB0 93.0%
ARP48898 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody F7ITB0 86.0%
ARP48898 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DM59 86.0%
ARP48898 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DXI4 86.0%
ARP48898 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3BNH5 86.0%
ARP48898 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3C6I3 86.0%
ARP35787 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3C6I3 83.0%
ARP48878 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DM59 79.0%
ARP35787 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DXI4 79.0%
ARP48878 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DXI4 79.0%
ARP35787 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3BNH5 79.0%
ARP48878 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3BNH5 79.0%
ARP48878 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3C6I3 79.0%
ARP35787 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody U3DM59 79.0%
ARP35787 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody F7ITB0 79.0%
ARP48878 White-tufted-ear marmoset CHST6 antibody; Callithrix jacchus CHST6 antibody F7ITB0 79.0%

Tissue & Cell Line Gene Expression Data