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Gene ID: 1129 | CHRM2 Antibody Resource


CHRM2 Antibody Resource
Gene Full Name: 
cholinergic receptor, muscarinic 2
Uniprot: 
P08172
Protein Name: 
muscarinic acetylcholine receptor M2
Nucleotide: 
NM_001006630
Alias: 
HM2;
Ensembl: 
ENSG00000181072
Location: 
7q31-q35
HPRD: 
00328
NCBI Gene: 
1129
MIM: 
118493

Summary: 
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Function: 
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
Subcellular location: 
Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
PTM: 
Disulfide bond;
Disease: 
Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP64240_P050 CHRM2 Antibody (ARP64240_P050) Polyclonal Bovine, Dog, Human, Pig, Rabbit, Sheep Not tested 50 ug $125 Details
Polyclonal Antibody OAAB10719 CHRM2 antibody - center region (OAAB10719) Human WB 400ul $289 Details
Polyclonal Antibody OAEC03270 CHRM2 Antibody (OAEC03270) Human; Mouse; Rat WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:5000 100ug $229 Details
Polyclonal Antibody OAAF04852 CHRM2 Antibody (OAAF04852) Polyclonal Human, Mouse, Rat WB, IF, ELISA 100 ug $229 Details

Show all CHRM2 antibodies


Product Images
CHRM2 antibody - center region (OAAB10719) in 293 cells using Western Blot

Sample Type: 293

CHRM2 antibody - center region (OAAB10719) in CEM cells using Western Blot

Sample Type: CEM

CHRM2 Antibody (OAAF04852) in LOVO cells using Immunofluorescence

Sample Type: LOVO

CHRM2 Antibody (OAAF04852) in MCF-7, HeLa cells using Western Blot

Sample Type: MCF-7, HeLa


CHRM2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP64240 Bornean orangutan CHRM2 antibody; Pongo pygmaeus CHRM2 antibody Q9N2A5 86.0%
ARP64240 Bovine CHRM2 antibody; Bos taurus CHRM2 antibody P41985 85.0%
ARP64240 Cat CHRM2 antibody; Felis catus CHRM2 antibody M3WSG4 85.0%
ARP64240 Chimpanzee CHRM2 antibody; Pan troglodytes CHRM2 antibody H2RAP9 100.0%
ARP64240 Chimpanzee CHRM2 antibody; Pan troglodytes CHRM2 antibody Q9N2A7 100.0%
ARP64240 Dog CHRM2 antibody; Canis familiaris CHRM2 antibody F1PWR7 85.0%
ARP64240 Human CHRM2 antibody; Homo sapiens CHRM2 antibody A4D1Q0 100.0%
ARP64240 Human CHRM2 antibody; Homo sapiens CHRM2 antibody P08172 100.0%
ARP64240 Human CHRM2 antibody; Homo sapiens CHRM2 antibody Q96RH0 100.0%
ARP64240 Northern white-cheeked gibbon CHRM2 antibody; Nomascus leucogenys CHRM2 antibody G1RTC8 93.0%
ARP64240 Pig CHRM2 antibody; Sus scrofa CHRM2 antibody P06199 85.0%
ARP64240 Rabbit CHRM2 antibody; Oryctolagus cuniculus CHRM2 antibody G1TBX1 85.0%
ARP64240 Rhesus macaque CHRM2 antibody; Macaca mulatta CHRM2 antibody H9FJR8 100.0%
ARP64240 Sheep CHRM2 antibody; Ovis aries CHRM2 antibody F6I891 92.0%
ARP64240 Small-eared galago CHRM2 antibody; Otolemur garnettii CHRM2 antibody H0WZP7 85.0%
ARP64240 Sumatran orangutan CHRM2 antibody; Pongo abelii CHRM2 antibody H2PNM1 93.0%
ARP64240 Thirteen-lined ground squirrel CHRM2 antibody; Spermophilus tridecemlineatus CHRM2 antibody I3NGW8 85.0%
ARP64240 western gorilla CHRM2 antibody; Gorilla gorilla CHRM2 antibody Q9N2A6 100.0%
ARP64240 White-tufted-ear marmoset CHRM2 antibody; Callithrix jacchus CHRM2 antibody F7APE0 93.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas221330_at721_B_lymphoblasts3.7503.120Details
BioGPS Gene Atlas221330_atAdipocyte2.9003.120Details
BioGPS Gene Atlas221330_atAdrenalCortex3.0003.120Details
BioGPS Gene Atlas221330_atAdrenalgland2.4503.120Details
BioGPS Gene Atlas221330_atAmygdala3.1003.120Details
BioGPS Gene Atlas221330_atAppendix3.0503.120Details
BioGPS Gene Atlas221330_atAtrioventricularNode2.2503.120Details
BioGPS Gene Atlas221330_atBDCA4+_DentriticCells3.3003.120Details
BioGPS Gene Atlas221330_atBonemarrow2.9003.120Details
BioGPS Gene Atlas221330_atBronchialEpithelialCells2.9003.120Details
BioGPS Gene Atlas221330_atCD105+_Endothelial3.0003.120Details
BioGPS Gene Atlas221330_atCD14+_Monocytes3.1003.120Details
BioGPS Gene Atlas221330_atCD19+_BCells(neg._sel.)3.1503.120Details
BioGPS Gene Atlas221330_atCD33+_Myeloid3.8003.120Details
BioGPS Gene Atlas221330_atCD34+3.7503.120Details
BioGPS Gene Atlas221330_atCD4+_Tcells3.2503.120Details
BioGPS Gene Atlas221330_atCD56+_NKCells3.5503.120Details
BioGPS Gene Atlas221330_atCD71+_EarlyErythroid2.7003.120Details
BioGPS Gene Atlas221330_atCD8+_Tcells2.9003.120Details
BioGPS Gene Atlas221330_atCardiacMyocytes3.6503.120Details
BioGPS Gene Atlas221330_atCaudatenucleus2.6003.120Details
BioGPS Gene Atlas221330_atCerebellum2.6003.120Details
BioGPS Gene Atlas221330_atCerebellumPeduncles3.3003.120Details
BioGPS Gene Atlas221330_atCiliaryGanglion2.9003.120Details
BioGPS Gene Atlas221330_atCingulateCortex3.0003.120Details
BioGPS Gene Atlas221330_atColorectaladenocarcinoma2.9003.120Details
BioGPS Gene Atlas221330_atDorsalRootGanglion3.6503.120Details
BioGPS Gene Atlas221330_atFetalThyroid2.8503.120Details
BioGPS Gene Atlas221330_atFetalbrain2.9503.120Details
BioGPS Gene Atlas221330_atFetalliver2.5503.120Details
BioGPS Gene Atlas221330_atFetallung2.4503.120Details
BioGPS Gene Atlas221330_atGlobusPallidus2.5003.120Details
BioGPS Gene Atlas221330_atHeart3.7503.120Details
BioGPS Gene Atlas221330_atHypothalamus3.2003.120Details
BioGPS Gene Atlas221330_atKidney2.3503.120Details
BioGPS Gene Atlas221330_atLeukemia_chronicMyelogenousK-5622.6503.120Details
BioGPS Gene Atlas221330_atLeukemia_promyelocytic-HL-602.6003.120Details
BioGPS Gene Atlas221330_atLeukemialymphoblastic(MOLT-4)2.3503.120Details
BioGPS Gene Atlas221330_atLiver3.8003.120Details
BioGPS Gene Atlas221330_atLung3.2503.120Details
BioGPS Gene Atlas221330_atLymphnode2.5503.120Details
BioGPS Gene Atlas221330_atLymphoma_burkitts(Daudi)3.7503.120Details
BioGPS Gene Atlas221330_atLymphoma_burkitts(Raji)4.0503.120Details
BioGPS Gene Atlas221330_atMedullaOblongata2.7003.120Details
BioGPS Gene Atlas221330_atOccipitalLobe2.6503.120Details
BioGPS Gene Atlas221330_atOlfactoryBulb2.3503.120Details
BioGPS Gene Atlas221330_atOvary2.1003.120Details
BioGPS Gene Atlas221330_atPancreas2.3503.120Details
BioGPS Gene Atlas221330_atPancreaticIslet3.1503.120Details
BioGPS Gene Atlas221330_atParietalLobe3.4003.120Details
BioGPS Gene Atlas221330_atPituitary3.4503.120Details
BioGPS Gene Atlas221330_atPlacenta3.0503.120Details
BioGPS Gene Atlas221330_atPons2.7503.120Details
BioGPS Gene Atlas221330_atPrefrontalCortex3.7003.120Details
BioGPS Gene Atlas221330_atProstate3.5003.120Details
BioGPS Gene Atlas221330_atSalivarygland2.3003.120Details
BioGPS Gene Atlas221330_atSkeletalMuscle7.9003.120Details
BioGPS Gene Atlas221330_atSkin2.2503.120Details
BioGPS Gene Atlas221330_atSmoothMuscle3.3003.120Details
BioGPS Gene Atlas221330_atSpinalcord3.1503.120Details
BioGPS Gene Atlas221330_atSubthalamicNucleus2.6503.120Details
BioGPS Gene Atlas221330_atSuperiorCervicalGanglion5.7003.120Details
BioGPS Gene Atlas221330_atTemporalLobe2.9003.120Details
BioGPS Gene Atlas221330_atTestis2.5003.120Details
BioGPS Gene Atlas221330_atTestisGermCell2.5003.120Details
BioGPS Gene Atlas221330_atTestisIntersitial2.4503.120Details
BioGPS Gene Atlas221330_atTestisLeydigCell2.9003.120Details
BioGPS Gene Atlas221330_atTestisSeminiferousTubule2.5003.120Details
BioGPS Gene Atlas221330_atThalamus3.0003.120Details
BioGPS Gene Atlas221330_atThymus2.3503.120Details
BioGPS Gene Atlas221330_atThyroid3.7003.120Details
BioGPS Gene Atlas221330_atTongue2.9003.120Details
BioGPS Gene Atlas221330_atTonsil2.8503.120Details
BioGPS Gene Atlas221330_atTrachea2.4503.120Details
BioGPS Gene Atlas221330_atTrigeminalGanglion2.9503.120Details
BioGPS Gene Atlas221330_atUterus2.4003.120Details
BioGPS Gene Atlas221330_atUterusCorpus3.2503.120Details
BioGPS Gene Atlas221330_atWholeBlood3.2503.120Details
BioGPS Gene Atlas221330_atWholebrain2.5003.120Details
BioGPS Gene Atlas221330_atcolon2.9503.120Details
BioGPS Gene Atlas221330_atpineal_day4.8403.120Details
BioGPS Gene Atlas221330_atpineal_night3.6403.120Details
BioGPS Gene Atlas221330_atretina3.5753.120Details
BioGPS Gene Atlas221330_atsmall_intestine2.8503.120Details
BioGPS NCI60221330_at7863.1033.060Details
BioGPS NCI60221330_atA1722.9863.060Details
BioGPS NCI60221330_atA2043.0183.060Details
BioGPS NCI60221330_atA3613.0733.060Details
BioGPS NCI60221330_atA4983.0583.060Details
BioGPS NCI60221330_atA5493.0893.060Details
BioGPS NCI60221330_atACC33.1303.060Details
BioGPS NCI60221330_atACHN2.9473.060Details
BioGPS NCI60221330_atALVA313.1343.060Details
BioGPS NCI60221330_atCAKI13.1143.060Details
BioGPS NCI60221330_atCCRT CEM3.4363.060Details
BioGPS NCI60221330_atCOLO2053.0383.060Details
BioGPS NCI60221330_atDLD13.0243.060Details
BioGPS NCI60221330_atDU1452.9653.060Details
BioGPS NCI60221330_atEKVX2.9973.060Details
BioGPS NCI60221330_atGM1333.1083.060Details
BioGPS NCI60221330_atGM16003.1443.060Details
BioGPS NCI60221330_atGM23133.0843.060Details
BioGPS NCI60221330_atGM23453.0603.060Details
BioGPS NCI60221330_atGM24933.1403.060Details
BioGPS NCI60221330_atGM973.2643.060Details
BioGPS NCI60221330_atHCC29982.9163.060Details
BioGPS NCI60221330_atHCT1163.0413.060Details
BioGPS NCI60221330_atHCT152.9513.060Details
BioGPS NCI60221330_atHEK 293 T-rex3.0833.060Details
BioGPS NCI60221330_atHEK 293T3.0623.060Details
BioGPS NCI60221330_atHEK2933.0583.060Details
BioGPS NCI60221330_atHELA2.9573.060Details
BioGPS NCI60221330_atHEPG23.0393.060Details
BioGPS NCI60221330_atHL603.0703.060Details
BioGPS NCI60221330_atHOP623.0593.060Details
BioGPS NCI60221330_atHOP923.0163.060Details
BioGPS NCI60221330_atHS578T3.0373.060Details
BioGPS NCI60221330_atHSG2.9943.060Details
BioGPS NCI60221330_atHT10803.0393.060Details
BioGPS NCI60221330_atHT293.1613.060Details
BioGPS NCI60221330_atIGROV13.0283.060Details
BioGPS NCI60221330_atIOSE803.0613.060Details
BioGPS NCI60221330_atJURKAT3.0453.060Details
BioGPS NCI60221330_atK5623.1603.060Details
BioGPS NCI60221330_atKM123.1183.060Details
BioGPS NCI60221330_atLN182.9703.060Details
BioGPS NCI60221330_atLNCAP3.0503.060Details
BioGPS NCI60221330_atLOX IMVI3.0453.060Details
BioGPS NCI60221330_atM143.0273.060Details
BioGPS NCI60221330_atMALME 3M3.1543.060Details
BioGPS NCI60221330_atMCF72.9943.060Details
BioGPS NCI60221330_atMD MB2313.0673.060Details
BioGPS NCI60221330_atMDA MB4353.1363.060Details
BioGPS NCI60221330_atMOLT43.0983.060Details
BioGPS NCI60221330_atNCI 4603.1333.060Details
BioGPS NCI60221330_atNCI H2263.0933.060Details
BioGPS NCI60221330_atNCI H233.0493.060Details
BioGPS NCI60221330_atNCI H322M3.0623.060Details
BioGPS NCI60221330_atNCVADR RES2.9763.060Details
BioGPS NCI60221330_atOVCAR33.1373.060Details
BioGPS NCI60221330_atOVCAR43.0393.060Details
BioGPS NCI60221330_atOVCAR53.0233.060Details
BioGPS NCI60221330_atOVCAR82.9603.060Details
BioGPS NCI60221330_atPANC13.0663.060Details
BioGPS NCI60221330_atRL73.0923.060Details
BioGPS NCI60221330_atRPMI 82263.0733.060Details
BioGPS NCI60221330_atRS118463.1223.060Details
BioGPS NCI60221330_atRXF3933.0413.060Details
BioGPS NCI60221330_atSAOS23.0793.060Details
BioGPS NCI60221330_atSF2683.0523.060Details
BioGPS NCI60221330_atSF2953.0103.060Details
BioGPS NCI60221330_atSF5392.9533.060Details
BioGPS NCI60221330_atSHSYSY+RA2.9973.060Details
BioGPS NCI60221330_atSHSYSY-RA3.0353.060Details
BioGPS NCI60221330_atSKMEL23.0493.060Details
BioGPS NCI60221330_atSKMEL283.0543.060Details
BioGPS NCI60221330_atSKMEL52.9923.060Details
BioGPS NCI60221330_atSKOV33.0993.060Details
BioGPS NCI60221330_atSN12C3.0563.060Details
BioGPS NCI60221330_atSNB192.9613.060Details
BioGPS NCI60221330_atSNB753.0413.060Details
BioGPS NCI60221330_atSR3.0903.060Details
BioGPS NCI60221330_atSW6203.0883.060Details
BioGPS NCI60221330_atT243.0943.060Details
BioGPS NCI60221330_atT3M43.1173.060Details
BioGPS NCI60221330_atTK103.0363.060Details
BioGPS NCI60221330_atU1183.0263.060Details
BioGPS NCI60221330_atU1382.9733.060Details
BioGPS NCI60221330_atU20S3.0313.060Details
BioGPS NCI60221330_atU2513.0273.060Details
BioGPS NCI60221330_atU873.0193.060Details
BioGPS NCI60221330_atUACC2573.0243.060Details
BioGPS NCI60221330_atUACC623.0793.060Details
BioGPS NCI60221330_atUO313.0093.060Details
BioGPS NCI60221330_atZR75_13.1003.060Details
BioGPS NCI60221330_atastrocytes3.0913.060Details
BioGPS NCI60221330_athuh-73.1193.060Details