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Gene ID: 63928 | CHP2 Antibody Resource


CHP2 Antibody Resource
Gene Full Name: 
calcineurin-like EF-hand protein 2
Uniprot: 
O43745
Protein Name: 
calcineurin B homologous protein 2
Nucleotide: 
NM_022097
Alias: 
Ensembl: 
ENSG00000166869
Location: 
16p12.2
HPRD: 
14259
NCBI Gene: 
63928
MIM: 

Summary: 
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
Function: 
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Subcellular location: 
Nucleus. Cytoplasm. Cell membrane. Note: Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane . Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm.
PTM: 
Lipoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP51258_P050 CHP2 Antibody (ARP51258_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAF03397 CHP2 Antibody (OAAF03397) Polyclonal Human, Mouse, Rat WB, ELISA 100 ug $229 Details

Show all CHP2 antibodies


Product Images
CHP2 Antibody (OAAF03397) in Jurkat, K562, HT-29 cells using Western Blot

Sample Type: Jurkat, K562, HT-29


CHP2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP51258 Chimpanzee CHP2 antibody; Pan troglodytes CHP2 antibody H2QAS5 100.0%
ARP51258 Human CHP2 antibody; Homo sapiens CHP2 antibody O43745 100.0%
ARP51258 Rhesus macaque CHP2 antibody; Macaca mulatta CHP2 antibody F7C5D7 100.0%
ARP51258 Sumatran orangutan CHP2 antibody; Pongo abelii CHP2 antibody H2NQF4 100.0%
ARP51258 White-tufted-ear marmoset CHP2 antibody; Callithrix jacchus CHP2 antibody F7I4N6 79.0%
ARP51258 White-tufted-ear marmoset CHP2 antibody; Callithrix jacchus CHP2 antibody U3F0I7 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas206149_at721_B_lymphoblasts4.8509.790Details
BioGPS Gene Atlas206149_atAdipocyte3.9009.790Details
BioGPS Gene Atlas206149_atAdrenalCortex4.1009.790Details
BioGPS Gene Atlas206149_atAdrenalgland3.3009.790Details
BioGPS Gene Atlas206149_atAmygdala4.2009.790Details
BioGPS Gene Atlas206149_atAppendix3.9009.790Details
BioGPS Gene Atlas206149_atAtrioventricularNode3.0509.790Details
BioGPS Gene Atlas206149_atBDCA4+_DentriticCells4.3009.790Details
BioGPS Gene Atlas206149_atBonemarrow3.9009.790Details
BioGPS Gene Atlas206149_atBronchialEpithelialCells3.8509.790Details
BioGPS Gene Atlas206149_atCD105+_Endothelial4.0009.790Details
BioGPS Gene Atlas206149_atCD14+_Monocytes4.2009.790Details
BioGPS Gene Atlas206149_atCD19+_BCells(neg._sel.)4.2009.790Details
BioGPS Gene Atlas206149_atCD33+_Myeloid5.2009.790Details
BioGPS Gene Atlas206149_atCD34+5.0509.790Details
BioGPS Gene Atlas206149_atCD4+_Tcells4.2509.790Details
BioGPS Gene Atlas206149_atCD56+_NKCells4.7509.790Details
BioGPS Gene Atlas206149_atCD71+_EarlyErythroid3.6509.790Details
BioGPS Gene Atlas206149_atCD8+_Tcells3.9009.790Details
BioGPS Gene Atlas206149_atCardiacMyocytes5.0009.790Details
BioGPS Gene Atlas206149_atCaudatenucleus3.5009.790Details
BioGPS Gene Atlas206149_atCerebellum3.1509.790Details
BioGPS Gene Atlas206149_atCerebellumPeduncles4.4509.790Details
BioGPS Gene Atlas206149_atCiliaryGanglion4.1509.790Details
BioGPS Gene Atlas206149_atCingulateCortex3.9509.790Details
BioGPS Gene Atlas206149_atColorectaladenocarcinoma3.9009.790Details
BioGPS Gene Atlas206149_atDorsalRootGanglion7.6509.790Details
BioGPS Gene Atlas206149_atFetalThyroid3.8009.790Details
BioGPS Gene Atlas206149_atFetalbrain3.9509.790Details
BioGPS Gene Atlas206149_atFetalliver3.4509.790Details
BioGPS Gene Atlas206149_atFetallung3.3009.790Details
BioGPS Gene Atlas206149_atGlobusPallidus3.1009.790Details
BioGPS Gene Atlas206149_atHeart4.8509.790Details
BioGPS Gene Atlas206149_atHypothalamus4.2509.790Details
BioGPS Gene Atlas206149_atKidney3.1009.790Details
BioGPS Gene Atlas206149_atLeukemia_chronicMyelogenousK-5623.5509.790Details
BioGPS Gene Atlas206149_atLeukemia_promyelocytic-HL-603.4509.790Details
BioGPS Gene Atlas206149_atLeukemialymphoblastic(MOLT-4)3.2009.790Details
BioGPS Gene Atlas206149_atLiver5.2509.790Details
BioGPS Gene Atlas206149_atLung4.3509.790Details
BioGPS Gene Atlas206149_atLymphnode3.3509.790Details
BioGPS Gene Atlas206149_atLymphoma_burkitts(Daudi)5.0009.790Details
BioGPS Gene Atlas206149_atLymphoma_burkitts(Raji)5.4009.790Details
BioGPS Gene Atlas206149_atMedullaOblongata3.5509.790Details
BioGPS Gene Atlas206149_atOccipitalLobe3.5509.790Details
BioGPS Gene Atlas206149_atOlfactoryBulb13.1009.790Details
BioGPS Gene Atlas206149_atOvary2.6009.790Details
BioGPS Gene Atlas206149_atPancreas3.1009.790Details
BioGPS Gene Atlas206149_atPancreaticIslet4.1509.790Details
BioGPS Gene Atlas206149_atParietalLobe4.1009.790Details
BioGPS Gene Atlas206149_atPituitary4.5509.790Details
BioGPS Gene Atlas206149_atPlacenta4.1009.790Details
BioGPS Gene Atlas206149_atPons3.9009.790Details
BioGPS Gene Atlas206149_atPrefrontalCortex4.9509.790Details
BioGPS Gene Atlas206149_atProstate4.7009.790Details
BioGPS Gene Atlas206149_atSalivarygland3.1009.790Details
BioGPS Gene Atlas206149_atSkeletalMuscle4.6509.790Details
BioGPS Gene Atlas206149_atSkin14.6009.790Details
BioGPS Gene Atlas206149_atSmoothMuscle4.4509.790Details
BioGPS Gene Atlas206149_atSpinalcord4.2009.790Details
BioGPS Gene Atlas206149_atSubthalamicNucleus3.9509.790Details
BioGPS Gene Atlas206149_atSuperiorCervicalGanglion6.2009.790Details
BioGPS Gene Atlas206149_atTemporalLobe3.5509.790Details
BioGPS Gene Atlas206149_atTestis3.4009.790Details
BioGPS Gene Atlas206149_atTestisGermCell3.5009.790Details
BioGPS Gene Atlas206149_atTestisIntersitial3.2509.790Details
BioGPS Gene Atlas206149_atTestisLeydigCell3.9009.790Details
BioGPS Gene Atlas206149_atTestisSeminiferousTubule3.9009.790Details
BioGPS Gene Atlas206149_atThalamus4.0009.790Details
BioGPS Gene Atlas206149_atThymus3.1509.790Details
BioGPS Gene Atlas206149_atThyroid4.9509.790Details
BioGPS Gene Atlas206149_atTongue3.9009.790Details
BioGPS Gene Atlas206149_atTonsil3.8009.790Details
BioGPS Gene Atlas206149_atTrachea3.4509.790Details
BioGPS Gene Atlas206149_atTrigeminalGanglion6.9509.790Details
BioGPS Gene Atlas206149_atUterus3.2509.790Details
BioGPS Gene Atlas206149_atUterusCorpus3.6009.790Details
BioGPS Gene Atlas206149_atWholeBlood4.3509.790Details
BioGPS Gene Atlas206149_atWholebrain3.3009.790Details
BioGPS Gene Atlas206149_atcolon106.5509.790Details
BioGPS Gene Atlas206149_atpineal_day4.9209.790Details
BioGPS Gene Atlas206149_atpineal_night4.8209.790Details
BioGPS Gene Atlas206149_atretina4.7509.790Details
BioGPS Gene Atlas206149_atsmall_intestine379.4009.790Details
BioGPS NCI60206149_at7864.0614.000Details
BioGPS NCI60206149_atA1723.9454.000Details
BioGPS NCI60206149_atA2043.9444.000Details
BioGPS NCI60206149_atA3614.0204.000Details
BioGPS NCI60206149_atA4984.0064.000Details
BioGPS NCI60206149_atA5494.0374.000Details
BioGPS NCI60206149_atACC34.0904.000Details
BioGPS NCI60206149_atACHN3.7754.000Details
BioGPS NCI60206149_atALVA314.2324.000Details
BioGPS NCI60206149_atCAKI14.1034.000Details
BioGPS NCI60206149_atCCRT CEM4.4374.000Details
BioGPS NCI60206149_atCOLO2053.9714.000Details
BioGPS NCI60206149_atDLD13.9274.000Details
BioGPS NCI60206149_atDU1453.8754.000Details
BioGPS NCI60206149_atEKVX3.8594.000Details
BioGPS NCI60206149_atGM1334.0454.000Details
BioGPS NCI60206149_atGM16004.0644.000Details
BioGPS NCI60206149_atGM23134.0354.000Details
BioGPS NCI60206149_atGM23454.0084.000Details
BioGPS NCI60206149_atGM24934.1444.000Details
BioGPS NCI60206149_atGM974.3444.000Details
BioGPS NCI60206149_atHCC29983.6914.000Details
BioGPS NCI60206149_atHCT1163.9694.000Details
BioGPS NCI60206149_atHCT153.8834.000Details
BioGPS NCI60206149_atHEK 293 T-rex4.0574.000Details
BioGPS NCI60206149_atHEK 293T3.9844.000Details
BioGPS NCI60206149_atHEK2934.0324.000Details
BioGPS NCI60206149_atHELA3.8854.000Details
BioGPS NCI60206149_atHEPG23.9764.000Details
BioGPS NCI60206149_atHL604.0544.000Details
BioGPS NCI60206149_atHOP624.0054.000Details
BioGPS NCI60206149_atHOP923.8984.000Details
BioGPS NCI60206149_atHS578T3.9374.000Details
BioGPS NCI60206149_atHSG3.8794.000Details
BioGPS NCI60206149_atHT10803.9784.000Details
BioGPS NCI60206149_atHT294.2064.000Details
BioGPS NCI60206149_atIGROV13.9604.000Details
BioGPS NCI60206149_atIOSE803.9734.000Details
BioGPS NCI60206149_atJURKAT3.9864.000Details
BioGPS NCI60206149_atK5624.0974.000Details
BioGPS NCI60206149_atKM124.1234.000Details
BioGPS NCI60206149_atLN183.9144.000Details
BioGPS NCI60206149_atLNCAP3.9864.000Details
BioGPS NCI60206149_atLOX IMVI3.9924.000Details
BioGPS NCI60206149_atM143.9524.000Details
BioGPS NCI60206149_atMALME 3M4.0984.000Details
BioGPS NCI60206149_atMCF73.8744.000Details
BioGPS NCI60206149_atMD MB2314.0104.000Details
BioGPS NCI60206149_atMDA MB4354.0894.000Details
BioGPS NCI60206149_atMOLT44.0804.000Details
BioGPS NCI60206149_atNCI 4604.1524.000Details
BioGPS NCI60206149_atNCI H2264.0884.000Details
BioGPS NCI60206149_atNCI H233.9754.000Details
BioGPS NCI60206149_atNCI H322M4.0004.000Details
BioGPS NCI60206149_atNCVADR RES3.8134.000Details
BioGPS NCI60206149_atOVCAR34.1034.000Details
BioGPS NCI60206149_atOVCAR43.9754.000Details
BioGPS NCI60206149_atOVCAR53.9344.000Details
BioGPS NCI60206149_atOVCAR83.7884.000Details
BioGPS NCI60206149_atPANC13.9954.000Details
BioGPS NCI60206149_atRL74.0644.000Details
BioGPS NCI60206149_atRPMI 82264.0254.000Details
BioGPS NCI60206149_atRS118464.0684.000Details
BioGPS NCI60206149_atRXF3933.9584.000Details
BioGPS NCI60206149_atSAOS24.0224.000Details
BioGPS NCI60206149_atSF2683.9974.000Details
BioGPS NCI60206149_atSF2953.9334.000Details
BioGPS NCI60206149_atSF5393.8784.000Details
BioGPS NCI60206149_atSHSYSY+RA3.8944.000Details
BioGPS NCI60206149_atSHSYSY-RA3.9734.000Details
BioGPS NCI60206149_atSKMEL23.9804.000Details
BioGPS NCI60206149_atSKMEL283.9924.000Details
BioGPS NCI60206149_atSKMEL53.9264.000Details
BioGPS NCI60206149_atSKOV34.0334.000Details
BioGPS NCI60206149_atSN12C3.9644.000Details
BioGPS NCI60206149_atSNB193.8964.000Details
BioGPS NCI60206149_atSNB753.9804.000Details
BioGPS NCI60206149_atSR4.0644.000Details
BioGPS NCI60206149_atSW6204.0404.000Details
BioGPS NCI60206149_atT244.0364.000Details
BioGPS NCI60206149_atT3M44.1654.000Details
BioGPS NCI60206149_atTK103.9834.000Details
BioGPS NCI60206149_atU1183.9824.000Details
BioGPS NCI60206149_atU1383.9214.000Details
BioGPS NCI60206149_atU20S4.0054.000Details
BioGPS NCI60206149_atU2513.9734.000Details
BioGPS NCI60206149_atU873.9624.000Details
BioGPS NCI60206149_atUACC2573.9594.000Details
BioGPS NCI60206149_atUACC624.0304.000Details
BioGPS NCI60206149_atUO313.8804.000Details
BioGPS NCI60206149_atZR75_14.1024.000Details
BioGPS NCI60206149_atastrocytes4.0674.000Details
BioGPS NCI60206149_athuh-74.1014.000Details