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Gene ID: 128866 | CHMP4B Antibody Resource


CHMP4B Antibody Resource
Gene Full Name: 
charged multivesicular body protein 4B
Uniprot: 
Q9H444
Protein Name: 
charged multivesicular body protein 4b
Nucleotide: 
NM_176812
Alias: 
SNF7;CTPP3;Shax1;CHMP4A;SNF7-2;VPS32B;CTRCT31;Vps32-2;C20orf178;dJ553F4.4;
Ensembl: 
ENSG00000101421
Location: 
20q11.22
HPRD: 
16642
NCBI Gene: 
128866
MIM: 
610897

Summary: 
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
Function: 
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
Subcellular location: 
Cytoplasm › cytosol. Late endosome membrane; Peripheral membrane protein Probable .
PTM: 
Acetylation;
Disease: 
Cataract 31, multiple types (CTRCT31) [MIM:605387]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT31 includes posterior polar, progressive posterior subcapsular, nuclear, and anterior subcapsular cataracts. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP53339_P050 CHMP4B antibody - middle region (ARP53339_P050) Polyclonal Bovine, Dog, Horse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody ARP53340_P050 CHMP4B antibody - middle region (ARP53340_P050) Polyclonal Bovine, Dog, Horse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody OAAB06125 CHMP4B antibody - N-terminal region (OAAB06125) Human WB, IHC, FC, ELISA 400ul $289 Details

Show all CHMP4B antibodies


Product Images
CHMP4B antibody - middle region (ARP53339_P050) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

CHMP4B antibody - middle region (ARP53339_P050) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

CHMP4B antibody - middle region (ARP53340_P050) in Human THP-1 cells using Western Blot

Sample Type: Human THP-1

CHMP4B antibody - N-terminal region (OAAB06125) in human brain carcinoma cells using Immunohistochemistry

Sample Type: human brain carcinoma

CHMP4B antibody - N-terminal region (OAAB06125) in MCF-7 cells using Flow Cytometry

Sample Type: MCF-7

CHMP4B antibody - N-terminal region (OAAB06125) in SK-BR-3 cells using Western Blot

Sample Type: SK-BR-3


CHMP4B Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP53339 African clawed frog CHMP4B antibody; Xenopus laevis CHMP4B antibody Q5XGW6 100.0%
ARP53340 African clawed frog CHMP4B antibody; Xenopus laevis CHMP4B antibody Q5XGW6 93.0%
ARP66539 African clawed frog CHMP4B antibody; Xenopus laevis CHMP4B antibody Q5XGW6 92.0%
ARP53339 Bovine CHMP4B antibody; Bos taurus CHMP4B antibody Q08E32 100.0%
ARP53340 Bovine CHMP4B antibody; Bos taurus CHMP4B antibody Q08E32 100.0%
ARP66539 Bovine CHMP4B antibody; Bos taurus CHMP4B antibody Q08E32 92.0%
ARP53339 Cat CHMP4B antibody; Felis catus CHMP4B antibody M3WXJ4 100.0%
ARP53340 Cat CHMP4B antibody; Felis catus CHMP4B antibody M3WXJ4 100.0%
ARP66539 Cat CHMP4B antibody; Felis catus CHMP4B antibody M3WXJ4 92.0%
ARP53339 Chicken CHMP4B antibody; Gallus gallus CHMP4B antibody Q5ZHP5 100.0%
ARP53340 Chicken CHMP4B antibody; Gallus gallus CHMP4B antibody Q5ZHP5 100.0%
ARP66539 Chicken CHMP4B antibody; Gallus gallus CHMP4B antibody Q5ZHP5 92.0%
ARP53339 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody K7ARG0 100.0%
ARP53340 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody K7ARG0 100.0%
ARP53339 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody K7BVL9 100.0%
ARP53340 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody K7BVL9 100.0%
ARP53339 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody H2QK75 100.0%
ARP53340 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody H2QK75 100.0%
ARP66539 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody K7ARG0 92.0%
ARP66539 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody K7BVL9 92.0%
ARP66539 Chimpanzee CHMP4B antibody; Pan troglodytes CHMP4B antibody H2QK75 92.0%
ARP53339 Chinese softshell turtle CHMP4B antibody; Pelodiscus sinensis CHMP4B antibody K7FHW1 100.0%
ARP53340 Chinese softshell turtle CHMP4B antibody; Pelodiscus sinensis CHMP4B antibody K7FHW1 93.0%
ARP66539 Chinese softshell turtle CHMP4B antibody; Pelodiscus sinensis CHMP4B antibody K7FHW1 85.0%
ARP53339 Collared flycatcher CHMP4B antibody; Ficedula albicollis CHMP4B antibody U3JTW0 100.0%
ARP53340 Collared flycatcher CHMP4B antibody; Ficedula albicollis CHMP4B antibody U3JTW0 100.0%
ARP66539 Collared flycatcher CHMP4B antibody; Ficedula albicollis CHMP4B antibody U3JTW0 92.0%
ARP53339 Dog CHMP4B antibody; Canis familiaris CHMP4B antibody E2RDX2 100.0%
ARP53340 Dog CHMP4B antibody; Canis familiaris CHMP4B antibody E2RDX2 100.0%
ARP66539 Dog CHMP4B antibody; Canis familiaris CHMP4B antibody E2RDX2 92.0%
ARP53339 Domestic duck CHMP4B antibody; Anas platyrhynchos CHMP4B antibody U3IYD9 100.0%
ARP53340 Domestic duck CHMP4B antibody; Anas platyrhynchos CHMP4B antibody U3IYD9 93.0%
ARP66539 Domestic duck CHMP4B antibody; Anas platyrhynchos CHMP4B antibody U3IYD9 92.0%
ARP53339 Duckbill platypus CHMP4B antibody; Ornithorhynchus anatinus CHMP4B antibody F7AY19 100.0%
ARP53340 Duckbill platypus CHMP4B antibody; Ornithorhynchus anatinus CHMP4B antibody F7AY19 100.0%
ARP66539 Duckbill platypus CHMP4B antibody; Ornithorhynchus anatinus CHMP4B antibody F7AY19 92.0%
ARP53339 European domestic ferret CHMP4B antibody; Mustela putorius furo CHMP4B antibody M3Z298 100.0%
ARP53340 European domestic ferret CHMP4B antibody; Mustela putorius furo CHMP4B antibody M3Z298 100.0%
ARP66539 European domestic ferret CHMP4B antibody; Mustela putorius furo CHMP4B antibody M3Z298 92.0%
ARP53339 Giant panda CHMP4B antibody; Ailuropoda melanoleuca CHMP4B antibody G1LR23 100.0%
ARP53340 Giant panda CHMP4B antibody; Ailuropoda melanoleuca CHMP4B antibody G1LR23 100.0%
ARP66539 Giant panda CHMP4B antibody; Ailuropoda melanoleuca CHMP4B antibody G1LR23 92.0%
ARP53339 Gray short-tailed opossum CHMP4B antibody; Monodelphis domestica CHMP4B antibody F7EIX3 100.0%
ARP53340 Gray short-tailed opossum CHMP4B antibody; Monodelphis domestica CHMP4B antibody F7EIX3 100.0%
ARP66539 Gray short-tailed opossum CHMP4B antibody; Monodelphis domestica CHMP4B antibody F7EIX3 92.0%
ARP53339 Horse CHMP4B antibody; Equus caballus CHMP4B antibody F6V2B6 100.0%
ARP53340 Horse CHMP4B antibody; Equus caballus CHMP4B antibody F6V2B6 100.0%
ARP66539 Horse CHMP4B antibody; Equus caballus CHMP4B antibody F6V2B6 92.0%
ARP53339 Human CHMP4B antibody; Homo sapiens CHMP4B antibody Q9H444 100.0%
ARP53340 Human CHMP4B antibody; Homo sapiens CHMP4B antibody Q9H444 100.0%
ARP66539 Human CHMP4B antibody; Homo sapiens CHMP4B antibody Q9H444 92.0%
ARP53339 Mouse CHMP4B antibody; Mus musculus CHMP4B antibody Q9D8B3 100.0%
ARP53340 Mouse CHMP4B antibody; Mus musculus CHMP4B antibody Q9D8B3 100.0%
ARP66539 Mouse CHMP4B antibody; Mus musculus CHMP4B antibody Q9D8B3 92.0%
ARP53339 Pig CHMP4B antibody; Sus scrofa CHMP4B antibody F1S4Z2 100.0%
ARP53340 Pig CHMP4B antibody; Sus scrofa CHMP4B antibody F1S4Z2 100.0%
ARP66539 Pig CHMP4B antibody; Sus scrofa CHMP4B antibody F1S4Z2 92.0%
ARP53339 Rabbit CHMP4B antibody; Oryctolagus cuniculus CHMP4B antibody G1U2E3 100.0%
ARP53340 Rabbit CHMP4B antibody; Oryctolagus cuniculus CHMP4B antibody G1U2E3 100.0%
ARP66539 Rabbit CHMP4B antibody; Oryctolagus cuniculus CHMP4B antibody G1U2E3 92.0%
ARP53339 Rhesus macaque CHMP4B antibody; Macaca mulatta CHMP4B antibody H9FPW6 100.0%
ARP53340 Rhesus macaque CHMP4B antibody; Macaca mulatta CHMP4B antibody H9FPW6 100.0%
ARP53339 Rhesus macaque CHMP4B antibody; Macaca mulatta CHMP4B antibody F7H0S7 100.0%
ARP53340 Rhesus macaque CHMP4B antibody; Macaca mulatta CHMP4B antibody F7H0S7 100.0%
ARP66539 Rhesus macaque CHMP4B antibody; Macaca mulatta CHMP4B antibody H9FPW6 92.0%
ARP66539 Rhesus macaque CHMP4B antibody; Macaca mulatta CHMP4B antibody F7H0S7 92.0%
ARP53339 Small-eared galago CHMP4B antibody; Otolemur garnettii CHMP4B antibody H0X2P8 100.0%
ARP53340 Small-eared galago CHMP4B antibody; Otolemur garnettii CHMP4B antibody H0X2P8 100.0%
ARP66539 Small-eared galago CHMP4B antibody; Otolemur garnettii CHMP4B antibody H0X2P8 92.0%
ARP53339 Sumatran orangutan CHMP4B antibody; Pongo abelii CHMP4B antibody H2P1P4 100.0%
ARP53340 Sumatran orangutan CHMP4B antibody; Pongo abelii CHMP4B antibody H2P1P4 100.0%
ARP66539 Sumatran orangutan CHMP4B antibody; Pongo abelii CHMP4B antibody H2P1P4 92.0%
ARP53339 Tasmanian devil CHMP4B antibody; Sarcophilus harrisii CHMP4B antibody G3WVB5 100.0%
ARP53340 Tasmanian devil CHMP4B antibody; Sarcophilus harrisii CHMP4B antibody G3WVB5 100.0%
ARP66539 Tasmanian devil CHMP4B antibody; Sarcophilus harrisii CHMP4B antibody G3WVB5 92.0%
ARP53339 Thirteen-lined ground squirrel CHMP4B antibody; Spermophilus tridecemlineatus CHMP4B antibody I3M5Q5 100.0%
ARP53340 Thirteen-lined ground squirrel CHMP4B antibody; Spermophilus tridecemlineatus CHMP4B antibody I3M5Q5 100.0%
ARP66539 Thirteen-lined ground squirrel CHMP4B antibody; Spermophilus tridecemlineatus CHMP4B antibody I3M5Q5 92.0%
ARP53339 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody Q6GL11 100.0%
ARP53339 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody F6TRC4 100.0%
ARP53339 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody F7C7V3 100.0%
ARP53340 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody Q6GL11 93.0%
ARP53340 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody F6TRC4 93.0%
ARP53340 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody F7C7V3 93.0%
ARP66539 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody F7C7V3 92.0%
ARP66539 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody Q6GL11 92.0%
ARP66539 Western clawed frog CHMP4B antibody; Xenopus tropicalis CHMP4B antibody F6TRC4 92.0%
ARP53339 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3EW49 100.0%
ARP53340 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3EW49 100.0%
ARP53339 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3CTV4 100.0%
ARP53340 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3CTV4 100.0%
ARP53339 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3CV11 100.0%
ARP53339 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6XMX7 100.0%
ARP53340 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3CV11 100.0%
ARP53340 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6XMX7 100.0%
ARP53339 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6XNX9 100.0%
ARP53340 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6XNX9 100.0%
ARP53339 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6YB24 100.0%
ARP53340 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6YB24 100.0%
ARP66539 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3EW49 92.0%
ARP66539 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3CTV4 92.0%
ARP66539 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody U3CV11 92.0%
ARP66539 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6XMX7 92.0%
ARP66539 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6XNX9 92.0%
ARP66539 White-tufted-ear marmoset CHMP4B antibody; Callithrix jacchus CHMP4B antibody F6YB24 92.0%
ARP53339 Zebra finch CHMP4B antibody; Taeniopygia guttata CHMP4B antibody H0YZW3 100.0%
ARP53340 Zebra finch CHMP4B antibody; Taeniopygia guttata CHMP4B antibody H0YZW3 100.0%
ARP66539 Zebra finch CHMP4B antibody; Taeniopygia guttata CHMP4B antibody H0YZW3 92.0%
ARP53339 Zebrafish CHMP4B antibody; Danio rerio CHMP4B antibody Q7ZVC4 100.0%
ARP53340 Zebrafish CHMP4B antibody; Danio rerio CHMP4B antibody Q7ZVC4 100.0%
ARP66539 Zebrafish CHMP4B antibody; Danio rerio CHMP4B antibody Q7ZVC4 92.0%

Tissue & Cell Line Gene Expression Data